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Naa60 N(alpha)-acetyltransferase 60, NatF catalytic subunit [ Mus musculus (house mouse) ]

Gene ID: 74763, updated on 28-Apr-2024

Summary

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Official Symbol
Naa60provided by MGI
Official Full Name
N(alpha)-acetyltransferase 60, NatF catalytic subunitprovided by MGI
Primary source
MGI:MGI:1922013
See related
Ensembl:ENSMUSG00000005982 AllianceGenome:MGI:1922013
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HAT4; NatF; Nat15; 1200013P24Rik
Summary
Predicted to enable H4 histone acetyltransferase activity; peptide alpha-N-acetyltransferase activity; and protein homodimerization activity. Predicted to be involved in cell population proliferation; nucleosome assembly; and protein acetylation. Predicted to act upstream of or within chromatin organization and chromosome segregation. Predicted to be located in Golgi apparatus and membrane. Predicted to be active in Golgi membrane. Orthologous to human NAA60 (N-alpha-acetyltransferase 60, NatF catalytic subunit). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 39.1), mammary gland adult (RPKM 28.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
16 A1; 16 2.28 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (3690365..3722645)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (3872496..3904781)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_39909 Neighboring gene predicted gene, 41409 Neighboring gene STARR-seq mESC enhancer starr_39910 Neighboring gene STARR-positive B cell enhancer ABC_E5522 Neighboring gene olfactory receptor family 2 subfamily C member 1 Neighboring gene zinc finger protein 174 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:3872304-3872526 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:3872697-3872880 Neighboring gene zinc finger protein 597 Neighboring gene STARR-positive B cell enhancer mm9_chr16:3884448-3884748 Neighboring gene RIKEN cDNA 1700037C18 gene Neighboring gene predicted gene, 41410 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:3908535-3908837 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:3909019-3909128 Neighboring gene clusterin associated protein 1 Neighboring gene prothymosin alpha-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Isolation of novel tissue-specific genes from cDNA libraries representing the individual tissue constituents of the gastrulating mouse embryo. Harrison SM, et al. Development, 1995 Aug. PMID 7671812
  2. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  3. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
Inferred from Electronic Annotation
more info
  
enables histone H4 acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables histone acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptide alpha-N-acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptide alpha-N-acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in N-terminal peptidyl-methionine acetylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in N-terminal peptidyl-methionine acetylation ISO
Inferred from Sequence Orthology
more info
  
involved_in N-terminal protein amino acid acetylation ISO
Inferred from Sequence Orthology
more info
  
involved_in cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within chromosome segregation IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleosome assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
N-alpha-acetyltransferase 60
Names
N-acetyltransferase 15 (GCN5-related, putative)
N-alpha-acetyltransferase F
histone acetyltransferase type B protein 4
natF catalytic subunit
NP_001277618.1
NP_083366.1
XP_006522742.1
XP_006522743.1
XP_017172644.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290689.1 → NP_001277618.1  N-alpha-acetyltransferase 60 isoform 2

    See identical proteins and their annotated locations for NP_001277618.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region and uses a downstream start codon compared to variant 1. It encodes isoform 2 which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC129021, AI035720, AI448494, AK004750
    Consensus CDS
    CCDS70676.1
    UniProtKB/TrEMBL
    H3BIY0
    Related
    ENSMUSP00000134768.2, ENSMUST00000176625.8
    Conserved Domains (2) summary
    pfam00583
    Location:12 → 90
    Acetyltransf_1; Acetyltransferase (GNAT) family
    cl21457
    Location:74 → 138
    TIM; TIM-like beta/alpha barrel domains

  2. NM_029090.3 → NP_083366.1  N-alpha-acetyltransferase 60 isoform 1

    See identical proteins and their annotated locations for NP_083366.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC129021, BG147816, BI739241, BY255312, CF540715
    Consensus CDS
    CCDS37239.1
    UniProtKB/Swiss-Prot
    Q9DBU2
    Related
    ENSMUSP00000140031.2, ENSMUST00000186375.8
    Conserved Domains (2) summary
    pfam00583
    Location:23 → 155
    Acetyltransf_1; Acetyltransferase (GNAT) family
    cl21457
    Location:139 → 203
    TIM; TIM-like beta/alpha barrel domains

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    3690365..3722645
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006522680.4 → XP_006522743.1  N-alpha-acetyltransferase 60 isoform X1

    See identical proteins and their annotated locations for XP_006522743.1

    UniProtKB/Swiss-Prot
    Q9DBU2
    Related
    ENSMUSP00000135206.2, ENSMUST00000150655.3
    Conserved Domains (2) summary
    pfam00583
    Location:23 → 155
    Acetyltransf_1; Acetyltransferase (GNAT) family
    cl21457
    Location:139 → 203
    TIM; TIM-like beta/alpha barrel domains

  2. XM_017317155.2 → XP_017172644.1  N-alpha-acetyltransferase 60 isoform X2

    UniProtKB/TrEMBL
    H3BJZ6
    Related
    ENSMUSP00000135188.2, ENSMUST00000143537.9
    Conserved Domains (1) summary
    cl17182
    Location:23 → 113
    NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate

  3. XM_006522679.3 → XP_006522742.1  N-alpha-acetyltransferase 60 isoform X1

    See identical proteins and their annotated locations for XP_006522742.1

    UniProtKB/Swiss-Prot
    Q9DBU2
    Conserved Domains (2) summary
    pfam00583
    Location:23 → 155
    Acetyltransf_1; Acetyltransferase (GNAT) family
    cl21457
    Location:139 → 203
    TIM; TIM-like beta/alpha barrel domains
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DBU2.1 GenPept UniProtKB/Swiss-Prot:Q9DBU2

Gene LinkOut

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