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Cpa5 carboxypeptidase A5 [ Mus musculus (house mouse) ]

Gene ID: 74649, updated on 11-Apr-2024

Summary

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Official Symbol
Cpa5provided by MGI
Official Full Name
carboxypeptidase A5provided by MGI
Primary source
MGI:MGI:1921899
See related
Ensembl:ENSMUSG00000029788 AllianceGenome:MGI:1921899
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4930430M09Rik
Summary
This gene encodes a member of the carboxypeptidase A family of zinc metalloproteases. The encoded preproprotein undergoes proteolytic processing that removes the N-terminal activation peptide to generate a functional enzyme. This gene is expressed in mouse testes where the encoded protein is localized to the germ cells. This gene is located in a cluster of carboxypeptidase genes on chromosome 6. [provided by RefSeq, Jul 2016]
Expression
Restricted expression toward testis adult (RPKM 29.3) See more
Orthologs
human all
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Genomic context

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Location:
6 A3.3; 6 12.52 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (30611009..30631744)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (30611010..30631745)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene carboxypeptidase A4 Neighboring gene predicted gene, 31453 Neighboring gene carboxypeptidase A1, pancreatic Neighboring gene centrosomal protein 41 Neighboring gene predicted gene 13782

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Predicted gene 31453 (Gm31453) and the gene encoding carboxypeptidase A5 (Cpa5) are not essential for spermatogenesis and male fertility in the mouse. Zhou Y, et al. Reprod Fertil Dev, 2021 Apr. PMID 33745502
  2. Identification and characterization of three members of the human metallocarboxypeptidase gene family. Wei S, et al. J Biol Chem, 2002 Apr 26. PMID 11836249
  3. Activated Notch1 prevents differentiation of pancreatic acinar cells and attenuate endocrine development. Hald J, et al. Dev Biol, 2003 Aug 15. PMID 12921743
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Predicted gene 31453 (Gm31453) and the gene encoding carboxypeptidase A5 (Cpa5) are not essential for spermatogenesis and male fertility in the mouse.
    Title: Predicted gene 31453 (Gm31453) and the gene encoding carboxypeptidase A5 (Cpa5) are not essential for spermatogenesis and male fertility in the mouse.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metallocarboxypeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
carboxypeptidase A5
NP_653120.1
XP_006505251.1
XP_006505253.1
XP_011239386.1
XP_017177284.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_144537.4 → NP_653120.1  carboxypeptidase A5 preproprotein

    See identical proteins and their annotated locations for NP_653120.1

    Status: REVIEWED

    Source sequence(s)
    AC155656, AK015256, BC138114
    Consensus CDS
    CCDS19976.1
    UniProtKB/Swiss-Prot
    Q8R4H4
    UniProtKB/TrEMBL
    B2RQW9
    Related
    ENSMUSP00000057722.5, ENSMUST00000062758.11
    Conserved Domains (2) summary
    cd03870
    Location:134 → 434
    M14_CPA; Peptidase M14 carboxypeptidase subfamily A/B-like; Carboxypeptidase A subgroup
    pfam02244
    Location:48 → 117
    Propep_M14; Carboxypeptidase activation peptide

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    30611009..30631744
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006505190.4 → XP_006505253.1  carboxypeptidase A5 isoform X1

    See identical proteins and their annotated locations for XP_006505253.1

    UniProtKB/Swiss-Prot
    Q8R4H4
    UniProtKB/TrEMBL
    B2RQW9
    Conserved Domains (2) summary
    cd03870
    Location:134 → 434
    M14_CPA; Peptidase M14 carboxypeptidase subfamily A/B-like; Carboxypeptidase A subgroup
    pfam02244
    Location:48 → 117
    Propep_M14; Carboxypeptidase activation peptide

  2. XM_017321795.1 → XP_017177284.1  carboxypeptidase A5 isoform X1

    UniProtKB/Swiss-Prot
    Q8R4H4
    UniProtKB/TrEMBL
    B2RQW9
    Related
    ENSMUSP00000110792.2, ENSMUST00000115139.8
    Conserved Domains (2) summary
    cd03870
    Location:134 → 434
    M14_CPA; Peptidase M14 carboxypeptidase subfamily A/B-like; Carboxypeptidase A subgroup
    pfam02244
    Location:48 → 117
    Propep_M14; Carboxypeptidase activation peptide

  3. XM_006505188.1 → XP_006505251.1  carboxypeptidase A5 isoform X1

    See identical proteins and their annotated locations for XP_006505251.1

    UniProtKB/Swiss-Prot
    Q8R4H4
    UniProtKB/TrEMBL
    B2RQW9
    Conserved Domains (2) summary
    cd03870
    Location:134 → 434
    M14_CPA; Peptidase M14 carboxypeptidase subfamily A/B-like; Carboxypeptidase A subgroup
    pfam02244
    Location:48 → 117
    Propep_M14; Carboxypeptidase activation peptide

  4. XM_011241084.1 → XP_011239386.1  carboxypeptidase A5 isoform X2

    Conserved Domains (1) summary
    cd03870
    Location:66 → 400
    M14_CPA; Peptidase M14 carboxypeptidase subfamily A/B-like; Carboxypeptidase A subgroup
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R4H4.1 GenPept UniProtKB/Swiss-Prot:Q8R4H4

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