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Fer1l4 fer-1 like family member 4 [ Mus musculus (house mouse) ]

Gene ID: 74562, updated on 21-Apr-2024

Summary

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Official Symbol
Fer1l4provided by MGI
Official Full Name
fer-1 like family member 4provided by MGI
Primary source
MGI:MGI:1921812
See related
Ensembl:ENSMUSG00000013338 AllianceGenome:MGI:1921812
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
9130402C12Rik
Summary
Predicted to enable metal ion binding activity. Predicted to be involved in plasma membrane organization. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in lower urinary tract and testis. Orthologous to human FER1L4 (fer-1 like family member 4 (pseudogene)). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in bladder adult (RPKM 23.1), stomach adult (RPKM 19.3) and 3 other tissues See more
Orthologs
all
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Genomic context

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Location:
2 H1; 2 77.32 cM
Exon count:
47
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (155861059..155894939, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (156019139..156053019, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene centrosomal protein 250 Neighboring gene predicted gene, 50621 Neighboring gene RIKEN cDNA 6430550D23 gene Neighboring gene STARR-positive B cell enhancer ABC_E9074 Neighboring gene ERGIC and golgi 3 Neighboring gene AE binding protein 2 pseudogene Neighboring gene predicted gene, 39970

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Testis-enriched ferlin, FER1L5, is required for Ca(2+)-activated acrosome reaction and male fertility. Morohoshi A, et al. Sci Adv, 2023 Jan 25. PMID 36696506, Free PMC Article
  2. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
  3. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in plasma membrane organization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
fer-1-like protein 4
Names
fer-1-like 4
otoferlin-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001136556.2 → NP_001130028.1  fer-1-like protein 4

    Status: VALIDATED

    Source sequence(s)
    AL833786
    UniProtKB/Swiss-Prot
    A3KGK3, B7ZCP2
    UniProtKB/TrEMBL
    Z4YL23
    Related
    ENSMUSP00000105240.2, ENSMUST00000109611.8
    Conserved Domains (9) summary
    cd04011
    Location:225 → 335
    C2B_Ferlin; C2 domain second repeat in Ferlin
    cd04017
    Location:967 → 1101
    C2D_Ferlin; C2 domain fourth repeat in Ferlin
    cd04018
    Location:391 → 540
    C2C_Ferlin; C2 domain third repeat in Ferlin
    cd04037
    Location:1449 → 1572
    C2E_Ferlin; C2 domain fifth repeat in Ferlin
    cd08373
    Location:3 → 129
    C2A_Ferlin; C2 domain first repeat in Ferlin
    cd08374
    Location:1692 → 1825
    C2F_Ferlin; C2 domain sixth repeat in Ferlin
    pfam08150
    Location:862 → 931
    FerB; FerB (NUC096) domain
    pfam08151
    Location:333 → 383
    FerI; FerI (NUC094) domain
    pfam16165
    Location:1834 → 1985
    Ferlin_C; Ferlin C-terminus

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    155861059..155894939 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006500307.1 → XP_006500370.1  fer-1-like protein 4 isoform X1

    UniProtKB/Swiss-Prot
    A3KGK3, B7ZCP2
    Conserved Domains (9) summary
    cd04011
    Location:225 → 335
    C2B_Ferlin; C2 domain second repeat in Ferlin
    cd04017
    Location:967 → 1101
    C2D_Ferlin; C2 domain fourth repeat in Ferlin
    cd04018
    Location:391 → 540
    C2C_Ferlin; C2 domain third repeat in Ferlin
    cd04037
    Location:1449 → 1572
    C2E_Ferlin; C2 domain fifth repeat in Ferlin
    cd08373
    Location:3 → 129
    C2A_Ferlin; C2 domain first repeat in Ferlin
    cd08374
    Location:1692 → 1825
    C2F_Ferlin; C2 domain sixth repeat in Ferlin
    pfam08150
    Location:862 → 931
    FerB; FerB (NUC096) domain
    pfam08151
    Location:333 → 383
    FerI; FerI (NUC094) domain
    pfam16165
    Location:1834 → 1940
    Ferlin_C; Ferlin C-terminus

  2. XM_006500309.4 → XP_006500372.1  fer-1-like protein 4 isoform X3

    Related
    ENSMUST00000150538.8
    Conserved Domains (5) summary
    cd04017
    Location:96 → 230
    C2D_Ferlin; C2 domain fourth repeat in Ferlin
    cd04037
    Location:578 → 701
    C2E_Ferlin; C2 domain fifth repeat in Ferlin
    cd08374
    Location:821 → 954
    C2F_Ferlin; C2 domain sixth repeat in Ferlin
    pfam08150
    Location:1 → 60
    FerB; FerB (NUC096) domain
    pfam16165
    Location:963 → 1116
    Ferlin_C; Ferlin C-terminus

  3. XM_006500308.2 → XP_006500371.1  fer-1-like protein 4 isoform X2

    UniProtKB/Swiss-Prot
    A3KGK3, B7ZCP2
    Conserved Domains (7) summary
    cd04011
    Location:225 → 335
    C2B_Ferlin; C2 domain second repeat in Ferlin
    cd04017
    Location:967 → 1101
    C2D_Ferlin; C2 domain fourth repeat in Ferlin
    cd04018
    Location:391 → 540
    C2C_Ferlin; C2 domain third repeat in Ferlin
    cd04037
    Location:1449 → 1572
    C2E_Ferlin; C2 domain fifth repeat in Ferlin
    cd08373
    Location:3 → 129
    C2A_Ferlin; C2 domain first repeat in Ferlin
    pfam08150
    Location:862 → 931
    FerB; FerB (NUC096) domain
    pfam08151
    Location:333 → 383
    FerI; FerI (NUC094) domain

RNA

  1. XR_003953731.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A3KGK3.3 GenPept UniProtKB/Swiss-Prot:A3KGK3

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