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Snx29 sorting nexin 29 [ Mus musculus (house mouse) ]

Gene ID: 74478, updated on 30-Apr-2024

Summary

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Official Symbol
Snx29provided by MGI
Official Full Name
sorting nexin 29provided by MGI
Primary source
MGI:MGI:1921728
See related
Ensembl:ENSMUSG00000071669 AllianceGenome:MGI:1921728
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm930; Gm1737; Gm11170; Rundc2a; 4933437K13Rik
Summary
Predicted to enable phosphatidylinositol binding activity. Orthologous to human SNX29 (sorting nexin 29). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in kidney adult (RPKM 7.8), spleen adult (RPKM 2.1) and 21 other tissues See more
Orthologs
human all
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Genomic context

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See Snx29 in Genome Data Viewer
Location:
16 A1; 16 6.46 cM
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (11140719..11576959)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (11322861..11759095)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:11254345-11254532 Neighboring gene STARR-seq mESC enhancer starr_40101 Neighboring gene microRNA 1945 Neighboring gene STARR-positive B cell enhancer mm9_chr16:11322815-11323116 Neighboring gene tumor necrosis factor receptor superfamily, member 17 Neighboring gene STARR-positive B cell enhancer mm9_chr16:11385888-11386189 Neighboring gene STARR-positive B cell enhancer ABC_E5524 Neighboring gene STARR-positive B cell enhancer ABC_E1181 Neighboring gene DEAH (Asp-Glu-Ala-His) box polypeptide 15 pseudogene Neighboring gene STARR-seq mESC enhancer starr_40106 Neighboring gene STARR-seq mESC enhancer starr_40107 Neighboring gene tyrosine-protein kinase SgK223 pseudogene Neighboring gene STARR-seq mESC enhancer starr_40108 Neighboring gene predicted gene, 32100 Neighboring gene STARR-seq mESC enhancer starr_40110 Neighboring gene STARR-seq mESC enhancer starr_40111 Neighboring gene RIKEN cDNA 4833415N18 gene Neighboring gene calcineurin-like phosphoesterase domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_40112 Neighboring gene predicted gene 9961

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The Phox (PX) domain proteins and membrane traffic. Seet LF, et al. Biochim Biophys Acta, 2006 Aug. PMID 16782399
  2. Mutagenesis of diploid mammalian genes by gene entrapment. Lin Q, et al. Nucleic Acids Res, 2006. PMID 17062627, Free PMC Article
  3. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
  4. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
  5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  

General protein information

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Preferred Names
sorting nexin-29
Names
RUN domain containing 2A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290148.1 → NP_001277077.1  sorting nexin-29 isoform b

    See identical proteins and their annotated locations for NP_001277077.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks several 5' exons but contains an alternate 5' terminal exon, and it thus differs in the 5' UTR and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is shorter than isoform a.
    Source sequence(s)
    AK017102, CR521963
    Consensus CDS
    CCDS79422.1
    UniProtKB/Swiss-Prot
    Q9D3S3
    Related
    ENSMUSP00000093993.3, ENSMUST00000096273.9
    Conserved Domains (2) summary
    cd07277
    Location:319 → 436
    PX_RUN; The phosphoinositide binding Phox Homology domain of uncharacterized proteins containing PX and RUN domains
    pfam10211
    Location:123 → 202
    Ax_dynein_light; Axonemal dynein light chain

  2. NM_001403235.1 → NP_001390164.1  sorting nexin-29 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC154233, AC154509, AC165252, AC167720

  3. NM_001403236.1 → NP_001390165.1  sorting nexin-29 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC154233, AC165252, AC167720

  4. NM_001403237.1 → NP_001390166.1  sorting nexin-29 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC154233, AC165252, AC167720

  5. NM_001403238.1 → NP_001390167.1  sorting nexin-29 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC154233, AC165252, AC167720

  6. NM_001403239.1 → NP_001390168.1  sorting nexin-29 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC154233, AC154509, AC165252, AC167720

  7. NM_028964.5 → NP_083240.2  sorting nexin-29 isoform a

    See identical proteins and their annotated locations for NP_083240.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC154233, AC154509, AC165252, AC167720
    Consensus CDS
    CCDS27963.2
    UniProtKB/Swiss-Prot
    Q8K050, Q9D3S3
    Related
    ENSMUSP00000138025.2, ENSMUST00000180792.8
    Conserved Domains (3) summary
    cd07277
    Location:661 → 778
    PX_RUN; The phosphoinositide binding Phox Homology domain of uncharacterized proteins containing PX and RUN domains
    pfam02759
    Location:44 → 179
    RUN; RUN domain
    pfam10211
    Location:465 → 544
    Ax_dynein_light; Axonemal dynein light chain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    11140719..11576959
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160170.1 → XP_036016063.1  sorting nexin-29 isoform X6

    Conserved Domains (3) summary
    cd07277
    Location:529 → 646
    PX_RUN; The phosphoinositide binding Phox Homology domain of uncharacterized proteins containing PX and RUN domains
    smart00593
    Location:1 → 45
    RUN; domain involved in Ras-like GTPase signaling
    COG1196
    Location:339 → 501
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  2. XM_030249318.1 → XP_030105178.1  sorting nexin-29 isoform X2

    Conserved Domains (3) summary
    cd07277
    Location:606 → 723
    PX_RUN; The phosphoinositide binding Phox Homology domain of uncharacterized proteins containing PX and RUN domains
    COG1196
    Location:416 → 578
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam02759
    Location:1 → 121
    RUN; RUN domain

  3. XM_030249320.2 → XP_030105180.1  sorting nexin-29 isoform X9

    Conserved Domains (2) summary
    cd07277
    Location:509 → 626
    PX_RUN; The phosphoinositide binding Phox Homology domain of uncharacterized proteins containing PX and RUN domains
    COG1196
    Location:319 → 481
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  4. XM_036160171.1 → XP_036016064.1  sorting nexin-29 isoform X7

    Conserved Domains (3) summary
    cd07277
    Location:528 → 645
    PX_RUN; The phosphoinositide binding Phox Homology domain of uncharacterized proteins containing PX and RUN domains
    smart00593
    Location:1 → 45
    RUN; domain involved in Ras-like GTPase signaling
    COG1196
    Location:338 → 500
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  5. XM_030249319.1 → XP_030105179.1  sorting nexin-29 isoform X8

    Conserved Domains (2) summary
    cd07277
    Location:510 → 627
    PX_RUN; The phosphoinositide binding Phox Homology domain of uncharacterized proteins containing PX and RUN domains
    COG1196
    Location:320 → 482
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  6. XM_006522670.5 → XP_006522733.1  sorting nexin-29 isoform X10

    Conserved Domains (2) summary
    cd07277
    Location:320 → 437
    PX_RUN; The phosphoinositide binding Phox Homology domain of uncharacterized proteins containing PX and RUN domains
    COG1196
    Location:130 → 292
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  7. XM_006522672.5 → XP_006522735.1  sorting nexin-29 isoform X11

    See identical proteins and their annotated locations for XP_006522735.1

    Conserved Domains (2) summary
    cd07277
    Location:304 → 421
    PX_RUN; The phosphoinositide binding Phox Homology domain of uncharacterized proteins containing PX and RUN domains
    COG1196
    Location:114 → 276
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001163498.1: Suppressed sequence

    Description
    NM_001163498.1: This RefSeq was permanently suppressed because the CDS was partial.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D3S3.2 GenPept UniProtKB/Swiss-Prot:Q9D3S3

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