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Zswim5 zinc finger SWIM-type containing 5 [ Mus musculus (house mouse) ]

Gene ID: 74464, updated on 5-Mar-2024

Summary

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Official Symbol
Zswim5provided by MGI
Official Full Name
zinc finger SWIM-type containing 5provided by MGI
Primary source
MGI:MGI:1921714
See related
Ensembl:ENSMUSG00000033948 AllianceGenome:MGI:1921714
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA1511; 4933426E21Rik
Summary
Predicted to enable zinc ion binding activity. Predicted to be part of Cul2-RING ubiquitin ligase complex. Is expressed in eye; male reproductive gland or organ; metanephros; small intestine; and telencephalon. Orthologous to human ZSWIM5 (zinc finger SWIM-type containing 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in whole brain E14.5 (RPKM 10.6), CNS E14 (RPKM 8.6) and 16 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 D1; 4 53.37 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (116731326..116846461)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (116877402..116989105)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E11251 Neighboring gene predicted gene 12996 Neighboring gene ribosomal protein L36, pseudogene 8 Neighboring gene predicted gene, 22092 Neighboring gene general transcription factor IIB pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:116666946-116667171 Neighboring gene uroporphyrinogen decarboxylase Neighboring gene HECT domain E3 ubiquitin protein ligase 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Developmental characterization of Zswim5 expression in the progenitor domains and tangential migration pathways of cortical interneurons in the mouse forebrain. Chang CC, et al. J Comp Neurol, 2020 Oct. PMID 32144752
  2. Temporal and regulatory dynamics of the inner ear transcriptome during development in mice. Cao R, et al. Sci Rep, 2022 Dec 7. PMID 36476755, Free PMC Article
  3. Molecular specification and patterning of progenitor cells in the lateral and medial ganglionic eminences. Tucker ES, et al. J Neurosci, 2008 Sep 17. PMID 18799682, Free PMC Article
  4. Loss of the neurodevelopmental gene Zswim6 alters striatal morphology and motor regulation. Tischfield DJ, et al. Neurobiol Dis, 2017 Jul. PMID 28433741, Free PMC Article
  5. Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Feb 28. PMID 12693553

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Developmental characterization of Zswim5 expression in the progenitor domains and tangential migration pathways of cortical interneurons in the mouse forebrain.
    Title: Developmental characterization of Zswim5 expression in the progenitor domains and tangential migration pathways of cortical interneurons in the mouse forebrain.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of Cul2-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger SWIM domain-containing protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001029912.3 → NP_001025083.1  zinc finger SWIM domain-containing protein 5

    See identical proteins and their annotated locations for NP_001025083.1

    Status: VALIDATED

    Source sequence(s)
    AL671671, AL683847
    Consensus CDS
    CCDS18520.1
    UniProtKB/Swiss-Prot
    Q80TC6
    Related
    ENSMUSP00000049474.4, ENSMUST00000044823.4

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    116731326..116846461
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164501.1 → XP_036020394.1  zinc finger SWIM domain-containing protein 5 isoform X1

    Conserved Domains (1) summary
    PHA03247
    Location:2 → 104
    PHA03247; large tegument protein UL36; Provisional
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80TC6.2 GenPept UniProtKB/Swiss-Prot:Q80TC6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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