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Lrguk leucine-rich repeats and guanylate kinase domain containing [ Mus musculus (house mouse) ]

Gene ID: 74354, updated on 5-Mar-2024

Summary

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Official Symbol
Lrgukprovided by MGI
Official Full Name
leucine-rich repeats and guanylate kinase domain containingprovided by MGI
Primary source
MGI:MGI:1921604
See related
Ensembl:ENSMUSG00000056215 AllianceGenome:MGI:1921604
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4921528H16Rik
Summary
Predicted to enable guanylate kinase activity. Involved in axoneme assembly and spermatogenesis. Located in acrosomal vesicle and manchette. Is expressed in olfactory epithelium. Orthologous to human LRGUK (leucine rich repeats and guanylate kinase domain containing). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 1.9), CNS E18 (RPKM 0.2) and 8 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 A3.3; 6 14.75 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (34006183..34110969)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (34029245..34134034)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene exocyst complex component 4 Neighboring gene predicted gene, 38785 Neighboring gene STARR-seq mESC enhancer starr_15525 Neighboring gene STARR-seq mESC enhancer starr_15527 Neighboring gene STARR-seq mESC enhancer starr_15528 Neighboring gene STARR-seq mESC enhancer starr_15529 Neighboring gene STARR-positive B cell enhancer ABC_E10372 Neighboring gene predicted gene 13853 Neighboring gene predicted gene, 38786 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:34079401-34079510 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:34106119-34106374 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:34126896-34127097 Neighboring gene solute carrier family 35, member B4 Neighboring gene predicted gene 13855

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. LRGUK1 is part of a multiprotein complex required for manchette function and male fertility. Okuda H, et al. FASEB J, 2017 Mar. PMID 28003339
  2. LRGUK-1 is required for basal body and manchette function during spermatogenesis and male fertility. Liu Y, et al. PLoS Genet, 2015 Mar. PMID 25781171, Free PMC Article
  3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (1)  1 citation
  • Endonuclease-mediated (3) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables guanylate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in axoneme assembly IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in acrosomal vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in manchette IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
leucine-rich repeat and guanylate kinase domain-containing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001401521.1 → NP_001388450.1  leucine-rich repeat and guanylate kinase domain-containing protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC153817
    UniProtKB/TrEMBL
    A0A2I3BQA5
    Related
    ENSMUSP00000153993.2, ENSMUST00000228187.2

  2. NM_001401523.1 → NP_001388452.1  leucine-rich repeat and guanylate kinase domain-containing protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC153817
    UniProtKB/TrEMBL
    A0A8Q0LUS2
    Related
    ENSMUSP00000159470.1, ENSMUST00000240538.1

  3. NM_028886.2 → NP_083162.1  leucine-rich repeat and guanylate kinase domain-containing protein isoform 3

    See identical proteins and their annotated locations for NP_083162.1

    Status: VALIDATED

    Source sequence(s)
    AC153817
    Consensus CDS
    CCDS51745.1
    UniProtKB/Swiss-Prot
    Q9D5S7
    Related
    ENSMUSP00000065146.4, ENSMUST00000070189.10
    Conserved Domains (6) summary
    cd00071
    Location:416 → 537
    GMPK; Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine ...
    cd00116
    Location:150 → 339
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:131 → 150
    LRR_RI; leucine-rich repeat [structural motif]
    pfam00625
    Location:417 → 599
    Guanylate_kin; Guanylate kinase
    pfam12799
    Location:260 → 300
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:282 → 339
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    34006183..34110969
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006506713.5 → XP_006506776.1  leucine-rich repeat and guanylate kinase domain-containing protein isoform X1

    Conserved Domains (4) summary
    PHA03247
    Location:678 → 1233
    PHA03247; large tegument protein UL36; Provisional
    cd00071
    Location:416 → 537
    GMPK; Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine ...
    sd00033
    Location:131 → 150
    LRR_RI; leucine-rich repeat [structural motif]
    NF033189
    Location:132 → 333
    internalin_A; class 1 internalin InlA

  2. XM_011241496.3 → XP_011239798.1  leucine-rich repeat and guanylate kinase domain-containing protein isoform X3

    Conserved Domains (2) summary
    PHA03247
    Location:132 → 649
    PHA03247; large tegument protein UL36; Provisional
    PRK12323
    Location:14 → 230
    PRK12323; DNA polymerase III subunit gamma/tau
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D5S7.1 GenPept UniProtKB/Swiss-Prot:Q9D5S7

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