U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Muc5b mucin 5, subtype B, tracheobronchial [ Mus musculus (house mouse) ]

Gene ID: 74180, updated on 21-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Muc5bprovided by MGI
Official Full Name
mucin 5, subtype B, tracheobronchialprovided by MGI
Primary source
MGI:MGI:1921430
See related
Ensembl:ENSMUSG00000066108 AllianceGenome:MGI:1921430
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MUC5; MUC9; mucin 5b; A130042M24; 2300002I04Rik
Summary
Acts upstream of or within defense response to bacterium and regulation of macrophage activation. Located in extracellular space. Is expressed in larynx and trachea. Human ortholog(s) of this gene implicated in bronchiolitis; idiopathic pulmonary fibrosis; and urinary bladder cancer. Orthologous to human MUC5B (mucin 5B, oligomeric mucus/gel-forming). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in genital fat pad adult (RPKM 37.9) and lung adult (RPKM 11.8) See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
7 F5; 7 87.29 cM
Exon count:
49
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (141392796..141426826)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (141839059..141873089)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene mucin 2 Neighboring gene mucin 5, subtypes A and C, tracheobronchial/gastric Neighboring gene STARR-seq mESC enhancer starr_20496 Neighboring gene toll interacting protein Neighboring gene STARR-seq mESC enhancer starr_20497 Neighboring gene predicted gene, 32539

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Epithelial Endoplasmic Reticulum Stress Enhances the Risk of Muc5b-associated Lung Fibrosis. Dobrinskikh E, et al. Am J Respir Cell Mol Biol, 2023 Jan. PMID 36108173, Free PMC Article
  2. Muc5b plays a role in the development of inflammation and fibrosis in hypersensitivity pneumonitis induced by Saccharopolyspora rectivirgula. Okamoto T, et al. Am J Physiol Lung Cell Mol Physiol, 2022 Sep 1. PMID 35881171, Free PMC Article
  3. MUC5B regulates goblet cell differentiation and reduces inflammation in a murine COPD model. Huang X, et al. Respir Res, 2022 Jan 18. PMID 35042537, Free PMC Article
  4. Genes, other than Muc5b, play a role in bleomycin-induced lung fibrosis. Dobrinskikh E, et al. Am J Physiol Lung Cell Mol Physiol, 2021 Aug 1. PMID 34160296, Free PMC Article
  5. Influence of silica particles on mucociliary structure and MUC5B expression in airways of C57BL/6 mice. Yu Q, et al. Exp Lung Res, 2020 Sep. PMID 32372722

See all (55) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Epithelial Endoplasmic Reticulum Stress Enhances the Risk of Muc5b-associated Lung Fibrosis.
    Title: Epithelial Endoplasmic Reticulum Stress Enhances the Risk of Muc5b-associated Lung Fibrosis.
  2. De novo NUF2 variant in a novel inherited bone marrow failure syndrome including microcephaly and renal hypoplasia.
    Title: De novo NUF2 variant in a novel inherited bone marrow failure syndrome including microcephaly and renal hypoplasia.
  3. Mucins MUC5AC and MUC5B Are Variably Packaged in the Same and in Separate Secretory Granules.
    Title: Mucins MUC5AC and MUC5B Are Variably Packaged in the Same and in Separate Secretory Granules.
  4. Muc5b plays a role in the development of inflammation and fibrosis in hypersensitivity pneumonitis induced by Saccharopolyspora rectivirgula.
    Title: Muc5b plays a role in the development of inflammation and fibrosis in hypersensitivity pneumonitis induced by Saccharopolyspora rectivirgula.
  5. Role of MUC5B during Group B Streptococcal Vaginal Colonization.
    Title: Role of MUC5B during Group B Streptococcal Vaginal Colonization.
  6. MUC5B regulates goblet cell differentiation and reduces inflammation in a murine COPD model.
    Title: MUC5B regulates goblet cell differentiation and reduces inflammation in a murine COPD model.
  7. Autophagy of mucin granules contributes to resolution of airway mucous metaplasia.
    Title: Autophagy of mucin granules contributes to resolution of airway mucous metaplasia.
  8. Genes, other than Muc5b, play a role in bleomycin-induced lung fibrosis.
    Title: Genes, other than Muc5b, play a role in bleomycin-induced lung fibrosis.
  9. Influence of silica particles on mucociliary structure and MUC5B expression in airways of C57BL/6 mice.
    Title: Influence of silica particles on mucociliary structure and MUC5B expression in airways of C57BL/6 mice.
  10. Normal murine respiratory tract has its mucus concentrated in clouds based on the Muc5b mucin.
    Title: Normal murine respiratory tract has its mucus concentrated in clouds based on the Muc5b mucin.
Submit: New GeneRIF Correction See all GeneRIFs (33)

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within defense response to bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of macrophage activation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
mucin-5B

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028801.2 → NP_083077.2  mucin-5B precursor

    Status: VALIDATED

    Source sequence(s)
    AK009011, AK037730, AL772165
    Consensus CDS
    CCDS52448.1
    UniProtKB/TrEMBL
    E9Q5I3, Q8K1G6
    Related
    ENSMUSP00000128276.2, ENSMUST00000165147.3
    Conserved Domains (11) summary
    PHA03255
    Location:3475 → 3621
    PHA03255; BDLF3; Provisional
    smart00041
    Location:4708 → 4790
    CT; C-terminal cystine knot-like domain (CTCK)
    smart00214
    Location:4570 → 4631
    VWC; von Willebrand factor (vWF) type C domain
    smart00215
    Location:391 → 436
    VWC_out; von Willebrand factor (vWF) type C domain
    smart00216
    Location:888 → 1047
    VWD; von Willebrand factor (vWF) type D domain
    smart00832
    Location:619 → 700
    C8; This domain contains 8 conserved cysteine residues
    pfam01826
    Location:333 → 389
    TIL; Trypsin Inhibitor like cysteine rich domain
    pfam04880
    Location:1676 → 1796
    NUDE_C; NUDE protein, C-terminal conserved region
    pfam05109
    Location:2920 → 3410
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam08742
    Location:1087 → 1157
    C8; C8 domain
    pfam13330
    Location:1574 → 1663
    Mucin2_WxxW; Mucin-2 protein WxxW repeating region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    141392796..141426826
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006508653.4 → XP_006508716.2  mucin-5B isoform X1

    UniProtKB/TrEMBL
    Q8K1G6
    Conserved Domains (11) summary
    PHA03255
    Location:3451 → 3597
    PHA03255; BDLF3; Provisional
    smart00041
    Location:4684 → 4766
    CT; C-terminal cystine knot-like domain (CTCK)
    smart00214
    Location:4546 → 4607
    VWC; von Willebrand factor (vWF) type C domain
    smart00215
    Location:367 → 412
    VWC_out; von Willebrand factor (vWF) type C domain
    smart00216
    Location:864 → 1023
    VWD; von Willebrand factor (vWF) type D domain
    smart00832
    Location:595 → 676
    C8; This domain contains 8 conserved cysteine residues
    pfam05109
    Location:2258 → 2471
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam01826
    Location:309 → 365
    TIL; Trypsin Inhibitor like cysteine rich domain
    pfam08742
    Location:4313 → 4374
    C8; C8 domain
    pfam13330
    Location:2475 → 2563
    Mucin2_WxxW; Mucin-2 protein WxxW repeating region
    pfam17823
    Location:1656 → 1842
    DUF5585; Family of unknown function (DUF5585)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous