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Dmgdh dimethylglycine dehydrogenase precursor [ Mus musculus (house mouse) ]

Gene ID: 74129, updated on 5-Mar-2024

Summary

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Official Symbol
Dmgdhprovided by MGI
Official Full Name
dimethylglycine dehydrogenase precursorprovided by MGI
Primary source
MGI:MGI:1921379
See related
Ensembl:ENSMUSG00000042102 AllianceGenome:MGI:1921379
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1200014D15Rik
Summary
This gene encodes an enzyme involved in the catabolism of choline, catalyzing the oxidative demethylation of dimethylglycine to form sarcosine. The enzyme is found as a monomer in the mitochondrial matrix, and uses flavin adenine dinucleotide and folate as cofactors. [provided by RefSeq, Jul 2013]
Expression
Biased expression in liver adult (RPKM 68.1), liver E18 (RPKM 28.7) and 3 other tissues See more
Orthologs
human all
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Genomic context

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Location:
13 C3; 13 47.88 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (93810944..93889331)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (93674436..93752823)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_35284 Neighboring gene STARR-seq mESC enhancer starr_35285 Neighboring gene STARR-seq mESC enhancer starr_35286 Neighboring gene betaine-homocysteine methyltransferase Neighboring gene STARR-seq mESC enhancer starr_35293 Neighboring gene betaine-homocysteine methyltransferase 2 Neighboring gene expressed sequence AW495222 Neighboring gene predicted gene, 41021 Neighboring gene arylsulfatase B Neighboring gene microRNA 5624

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Protection of cardiomyocytes from ischemic/hypoxic cell death via Drbp1 and pMe2GlyDH in cardio-specific ARC transgenic mice. Pyo JO, et al. J Biol Chem, 2008 Nov 7. PMID 18782777, Free PMC Article
  2. Liver and brain differential expression of one-carbon metabolism genes during ontogenesis. Imbard A, et al. Sci Rep, 2021 Oct 26. PMID 34702858, Free PMC Article
  3. Integrated microarray and ChIP analysis identifies multiple Foxa2 dependent target genes in the notochord. Tamplin OJ, et al. Dev Biol, 2011 Dec 15. PMID 22008794
  4. Identification of anchor genes during kidney development defines ontological relationships, molecular subcompartments and regulatory pathways. Thiagarajan RD, et al. PLoS One, 2011 Feb 28. PMID 21386911, Free PMC Article
  5. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ARC may protect cardiomyocytes from hypoxic cell death by regulating its downstream, Drbp1 and pMe(2)GlyDH
    Title: Protection of cardiomyocytes from ischemic/hypoxic cell death via Drbp1 and pMe2GlyDH in cardio-specific ARC transgenic mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC107623

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables dimethylglycine dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dimethylglycine dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
  
enables flavin adenine dinucleotide binding ISO
Inferred from Sequence Orthology
more info
  
enables folic acid binding ISO
Inferred from Sequence Orthology
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in choline catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in tetrahydrofolate interconversion ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
dimethylglycine dehydrogenase, mitochondrial
Names
ME2GLYDH
NP_083048.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028772.3 → NP_083048.1  dimethylglycine dehydrogenase, mitochondrial precursor

    See identical proteins and their annotated locations for NP_083048.1

    Status: VALIDATED

    Source sequence(s)
    AC131739, CT030023
    Consensus CDS
    CCDS26690.1
    UniProtKB/Swiss-Prot
    B1B1D0, Q8R1S7, Q9DBT9
    UniProtKB/TrEMBL
    Q5EBH4
    Related
    ENSMUSP00000039663.7, ENSMUST00000048001.8
    Conserved Domains (6) summary
    COG0404
    Location:481 → 850
    GcvT; Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]
    COG0665
    Location:40 → 428
    DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]
    pfam01571
    Location:475 → 738
    GCV_T; Aminomethyltransferase folate-binding domain
    pfam08669
    Location:746 → 838
    GCV_T_C; Glycine cleavage T-protein C-terminal barrel domain
    pfam16350
    Location:410 → 465
    FAO_M; FAD dependent oxidoreductase central domain
    cl21454
    Location:38 → 83
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    93810944..93889331
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DBT9.1 GenPept UniProtKB/Swiss-Prot:Q9DBT9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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