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Ttc21a tetratricopeptide repeat domain 21A [ Mus musculus (house mouse) ]

Gene ID: 74052, updated on 21-Apr-2024

Summary

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Official Symbol
Ttc21aprovided by MGI
Official Full Name
tetratricopeptide repeat domain 21Aprovided by MGI
Primary source
MGI:MGI:1921302
See related
Ensembl:ENSMUSG00000032514 AllianceGenome:MGI:1921302
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Thm2; 4921538N17Rik
Summary
Involved in flagellated sperm motility and spermatid development. Predicted to be part of intraciliary transport particle A. Is expressed in 4th ventricle; choroid plexus; lateral ventricle choroid plexus; and olfactory epithelium. Human ortholog(s) of this gene implicated in spermatogenic failure 37. Orthologous to human TTC21A (tetratricopeptide repeat domain 21A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 28.9), lung adult (RPKM 4.7) and 1 other tissue See more
Orthologs
human all
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Genomic context

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Location:
9 F4; 9 71.33 cM
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (119766656..119798496)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (119937589..119969430)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:119803875-119804062 Neighboring gene predicted gene 2449 Neighboring gene WD repeat domain 48 Neighboring gene golgi reassembly stacking protein 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:119887435-119887544 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:119888013-119888122 Neighboring gene cysteine-serine-rich nuclear protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E6811 Neighboring gene STARR-positive B cell enhancer ABC_E2922 Neighboring gene STARR-positive B cell enhancer ABC_E3866 Neighboring gene predicted gene, 33800 Neighboring gene STARR-seq mESC enhancer starr_25485 Neighboring gene STARR-seq mESC enhancer starr_25486 Neighboring gene STARR-positive B cell enhancer ABC_E9780

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Thm2 interacts with paralog, Thm1, and sensitizes to Hedgehog signaling in postnatal skeletogenesis. Allard BA, et al. Cell Mol Life Sci, 2021 Apr. PMID 33683377, Free PMC Article
  2. Genetic interaction of mammalian IFT-A paralogs regulates cilia disassembly, ciliary entry of membrane protein, Hedgehog signaling, and embryogenesis. Wang W, et al. FASEB J, 2020 May. PMID 32167205, Free PMC Article
  3. Bi-allelic Mutations in TTC21A Induce Asthenoteratospermia in Humans and Mice. Liu W, et al. Am J Hum Genet, 2019 Apr 4. PMID 30929735, Free PMC Article
  4. THM1 negatively modulates mouse sonic hedgehog signal transduction and affects retrograde intraflagellar transport in cilia. Tran PV, et al. Nat Genet, 2008 Apr. PMID 18327258, Free PMC Article
  5. Tissue expression patterns identify mouse cilia genes. McClintock TS, et al. Physiol Genomics, 2008 Jan 17. PMID 17971504

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (2)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in flagellated sperm motility IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in flagellated sperm motility ISO
Inferred from Sequence Orthology
more info
  
involved_in intraciliary retrograde transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to cilium IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spermatid development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spermatid development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of intraciliary transport particle A IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
tetratricopeptide repeat protein 21A
Names
TPR repeat protein 21A
tetratricopeptide repeat-containing hedgehog modulator 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028735.3 → NP_083011.2  tetratricopeptide repeat protein 21A

    See identical proteins and their annotated locations for NP_083011.2

    Status: VALIDATED

    Source sequence(s)
    AC124662, AK029952, BC133699
    Consensus CDS
    CCDS40805.1
    UniProtKB/Swiss-Prot
    Q0HA37, Q3V0A2, Q8C0S4, Q9D5Q9
    Related
    ENSMUSP00000035100.6, ENSMUST00000035100.6
    Conserved Domains (4) summary
    TIGR02917
    Location:209 → 1048
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:495 → 522
    TPR; TPR repeat [structural motif]
    pfam13414
    Location:1198 → 1259
    TPR_11; TPR repeat
    cl21457
    Location:50 → 106
    TIM_phosphate_binding; TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    119766656..119798496
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006512321.3 → XP_006512384.1  tetratricopeptide repeat protein 21A isoform X1

    Conserved Domains (2) summary
    TIGR02917
    Location:209 → 1048
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:495 → 522
    TPR; TPR repeat [structural motif]

  2. XM_036155346.1 → XP_036011239.1  tetratricopeptide repeat protein 21A isoform X2

    Related
    ENSMUST00000159128.8
    Conserved Domains (3) summary
    TIGR02917
    Location:209 → 1048
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:495 → 522
    TPR; TPR repeat [structural motif]
    cl21457
    Location:50 → 106
    TIM; TIM-like beta/alpha barrel domains

  3. XM_036155347.1 → XP_036011240.1  tetratricopeptide repeat protein 21A isoform X3

    Conserved Domains (2) summary
    TIGR02917
    Location:55 → 617
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:64 → 91
    TPR; TPR repeat [structural motif]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C0S4.2 GenPept UniProtKB/Swiss-Prot:Q8C0S4

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