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Muc16 mucin 16 [ Mus musculus (house mouse) ]

Gene ID: 73732, updated on 3-Apr-2024

Summary

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Official Symbol
Muc16provided by MGI
Official Full Name
mucin 16provided by MGI
Primary source
MGI:MGI:1920982
See related
Ensembl:ENSMUSG00000109564 AllianceGenome:MGI:1920982
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ca125; Gm1480; Gm21044; 1110008I14Rik
Summary
Acts upstream of or within negative regulation of epithelial cell proliferation; negative regulation of interleukin-6 production; and negative regulation of wound healing. Located in external side of plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; mesothelium; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in ovarian cancer. Orthologous to human MUC16 (mucin 16, cell surface associated). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
human all
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Genomic context

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See Muc16 in Genome Data Viewer
Location:
9 A2; 9 7.06 cM
Exon count:
89
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (18406741..18586117, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (18495445..18674821, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_23418 Neighboring gene STARR-seq mESC enhancer starr_23419 Neighboring gene zinc finger protein 558 Neighboring gene STARR-seq mESC enhancer starr_23420 Neighboring gene methyl-CpG binding domain protein 3-like 1 Neighboring gene predicted gene, 39297 Neighboring gene predicted gene, 24546 Neighboring gene STARR-seq mESC enhancer starr_23423 Neighboring gene olfactory receptor family 1 subfamily M member 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Transformation of NIH3T3 mouse fibroblast cells by MUC16 mucin (CA125) is driven by its cytoplasmic tail. Giannakouros P, et al. Int J Oncol, 2015 Jan. PMID 25338620
  2. Heterologous immunization, a way out of the problem of monoclonal antibody production against carcinoma antigen 125. Shojaeian S, et al. Iran J Immunol, 2009 Dec. PMID 20054105
  3. CA125/MUC16 is dispensable for mouse development and reproduction. Cheon DJ, et al. PLoS One, 2009. PMID 19262696, Free PMC Article
  4. MUC16 suppresses human and murine innate immune responses. Felder M, et al. Gynecol Oncol, 2019 Mar. PMID 30626487, Free PMC Article
  5. MUC16 expression during embryogenesis, in adult tissues, and ovarian cancer in the mouse. Wang Y, et al. Differentiation, 2008 Dec. PMID 18637025, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Muc16 depletion diminishes KRAS-induced tumorigenesis and metastasis by altering tumor microenvironment factors in pancreatic ductal adenocarcinoma.
    Title: Muc16 depletion diminishes KRAS-induced tumorigenesis and metastasis by altering tumor microenvironment factors in pancreatic ductal adenocarcinoma.
  2. Authors confirm that MUC16 inhibits cytolysis by human NK cells as well as the formation of NK-tumor conjugates. Mice implanted with MUC16-knockdown OVCAR-3 show >2-fold increase in survival compared to controls. Murine NK cells and macrophages are more efficient at lysing MUC16-knockdown cells.
    Title: MUC16 suppresses human and murine innate immune responses.
  3. Mesothelin/mucin 16 signaling in activated portal fibroblasts regulates cholestatic liver fibrosis.(
    Title: Mesothelin/mucin 16 signaling in activated portal fibroblasts regulates cholestatic liver fibrosis.
  4. MAMs MUC1 and MUC16 contribute to the maintenance of immune homeostasis at the ocular surface by limiting TLR-mediated innate immune responses.
    Title: Suppression of Toll-like receptor-mediated innate immune responses at the ocular surface by the membrane-associated mucins MUC1 and MUC16.
  5. MUC16 functions as an oncogene. The cytoplasmic tail is critical for MUC16 oncogenic properties.
    Title: Transformation of NIH3T3 mouse fibroblast cells by MUC16 mucin (CA125) is driven by its cytoplasmic tail.
  6. Data show that intraperitoneal injections of living CA 125 positive cells of OVCAR-3 cell line, and boosted by intravenous injection of the purified extracellular domain of CA 125 was found to have excellent immunoreactivity for CA 125 mAb production.
    Title: Heterologous immunization, a way out of the problem of monoclonal antibody production against carcinoma antigen 125.
  7. Lack of any prominent abnormal phenotype in Muc16 knockout mice suggests that CA125/MUC16 is not required for normal development or reproduction
    Title: CA125/MUC16 is dispensable for mouse development and reproduction.
  8. the presence of MUC16 in murine ovarian cancer and in normal tissues
    Title: MUC16 expression during embryogenesis, in adult tissues, and ovarian cancer in the mouse.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of interleukin-6 production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of wound healing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
mucin-16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001378248.1 → NP_001365177.1  mucin-16 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC154519, AC154784, AC162941
    UniProtKB/TrEMBL
    A0A140LJ72
    Conserved Domains (4) summary
    pfam05109
    Location:4987 → 5361
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam01390
    Location:8618 → 8725
    SEA; SEA domain
    NF033849
    Location:4828 → 5122
    ser_rich_anae_1; serine-rich protein
    cl41733
    Location:8748 → 8782
    Syt1_2_N; N-terminal domain of synaptotagmin-1 and -2

  2. NM_001428752.1 → NP_001415681.1  mucin-16 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC154519, AC154784, AC162941

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    18406741..18586117 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011242634.1 → XP_011240936.1  mucin-16 isoform X1

    Related
    ENSMUSP00000147104.2, ENSMUST00000208663.2
    Conserved Domains (2) summary
    pfam05109
    Location:4987 → 5361
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam01390
    Location:6180 → 6281
    SEA; SEA domain

  2. XM_011242636.1 → XP_011240938.1  mucin-16 isoform X2

    See identical proteins and their annotated locations for XP_011240938.1

    UniProtKB/TrEMBL
    A0A140LJ72
    Conserved Domains (3) summary
    pfam05109
    Location:4962 → 5336
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam01390
    Location:6155 → 6256
    SEA; SEA domain
    pfam16038
    Location:8734 → 8788
    TMIE; TMIE protein
Nucleotide Protein Strain
Heading Accession and Version

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