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Gucy2g guanylate cyclase 2g [ Mus musculus (house mouse) ]

Gene ID: 73707, updated on 12-May-2024

Summary

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Official Symbol
Gucy2gprovided by MGI
Official Full Name
guanylate cyclase 2gprovided by MGI
Primary source
MGI:MGI:106025
See related
Ensembl:ENSMUSG00000055523 AllianceGenome:MGI:106025
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GC-G; 2410077I05Rik
Summary
Enables guanylate cyclase activity. Predicted to be involved in cGMP biosynthetic process and receptor guanylyl cyclase signaling pathway. Located in external side of plasma membrane. Is expressed in several structures, including genitourinary system; immune system; liver; musculature; and stomach. Orthologous to human GUCY2GP (guanylate cyclase 2G, pseudogene). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in genital fat pad adult (RPKM 1.8), cortex adult (RPKM 1.3) and 9 other tissues See more
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Genomic context

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Location:
19 D2; 19 51.18 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (55186531..55229684, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (55198099..55241252, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31418 Neighboring gene tectorin beta Neighboring gene microRNA 6715 Neighboring gene STARR-seq mESC enhancer starr_46491 Neighboring gene STARR-seq mESC enhancer starr_46492 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:55328374-55328561 Neighboring gene STARR-positive B cell enhancer ABC_E8758 Neighboring gene acyl-CoA synthetase long-chain family member 5 Neighboring gene predicted gene, 31595 Neighboring gene zinc finger, DHHC domain containing 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Guanylyl cyclase-G modulates jejunal apoptosis and inflammation in mice with intestinal ischemia and reperfusion. Lo HC, et al. PLoS One, 2014. PMID 24992336, Free PMC Article
  2. Disruption of guanylyl cyclase-G protects against acute renal injury. Lin H, et al. J Am Soc Nephrol, 2008 Feb. PMID 18199799, Free PMC Article
  3. Localization and characterization of an orphan receptor, guanylyl cyclase-G, in mouse testis and sperm. Huang YH, et al. Endocrinology, 2006 Oct. PMID 16857755
  4. Identification of an orphan guanylate cyclase receptor selectively expressed in mouse testis. Kuhn M, et al. Biochem J, 2004 Apr 15. PMID 14713286, Free PMC Article
  5. Guanylyl cyclase-G is an alarm pheromone receptor in mice. Chao YC, et al. EMBO J, 2018 Jan 4. PMID 28963397, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. it was observed that dimerization/oligomerization of GC-G, a process generally considered as critical for enzymatic activity of GCs, is strongly enhanced by coolness.
    Title: Receptor guanylyl cyclase-G is a novel thermosensory protein activated by cool temperatures.
  2. mGC-G is a sperm cell surface protein that possibly functions in early signaling event regulating calcium influx/efflux and sperm motility.
    Title: Localization and characterization of an orphan receptor, guanylyl cyclase-G, in mouse testis and sperm.
  3. GC-G may act as an early signaling molecule that promotes apoptotic and inflammatory responses in I/R-induced acute renal injury
    Title: Disruption of guanylyl cyclase-G protects against acute renal injury.
  4. Cloning of a guanylate cyclase receptor, GC-G, that is selective expressed in the testis [GC-G]
    Title: Identification of an orphan guanylate cyclase receptor selectively expressed in mouse testis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (3)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables adenylate cyclase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanylate cyclase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanylate cyclase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables guanylate cyclase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables peptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphorus-oxygen lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cGMP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cGMP biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in cyclic nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in receptor guanylyl cyclase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
guanylate cyclase 2G
Names
guanylyl cyclase receptor G
NP_001074545.1
NP_001357941.1
XP_030106960.1
XP_030106961.1
XP_030106962.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081076.3 → NP_001074545.1  guanylate cyclase 2G isoform 1 precursor

    See identical proteins and their annotated locations for NP_001074545.1

    Status: VALIDATED

    Source sequence(s)
    AC110206, AC133100
    Consensus CDS
    CCDS38026.1
    UniProtKB/Swiss-Prot
    Q6TL19, Q8BWU7
    Related
    ENSMUSP00000068253.7, ENSMUST00000069183.8
    Conserved Domains (3) summary
    smart00044
    Location:865 → 1055
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    cd13992
    Location:555 → 829
    PK_GC; Pseudokinase domain of membrane Guanylate Cyclase receptors
    cd06372
    Location:47 → 436
    PBP1_GC_G-like; Ligand-binding domain of membrane guanylyl cyclase G

  2. NM_001371012.1 → NP_001357941.1  guanylate cyclase 2G isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC133100, AK049940
    Conserved Domains (2) summary
    smart00044
    Location:224 → 414
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    cl21453
    Location:30 → 188
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    55186531..55229684 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030251102.2 → XP_030106962.1  guanylate cyclase 2G isoform X3

    Conserved Domains (2) summary
    smart00044
    Location:172 → 362
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    cl21453
    Location:30 → 136
    PKc_like; Protein Kinases, catalytic domain

  2. XM_030251100.2 → XP_030106960.1  guanylate cyclase 2G isoform X1

    Conserved Domains (2) summary
    smart00044
    Location:224 → 396
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    cl21453
    Location:30 → 188
    PKc_like; Protein Kinases, catalytic domain

  3. XM_030251101.2 → XP_030106961.1  guanylate cyclase 2G isoform X2

    Conserved Domains (2) summary
    smart00044
    Location:172 → 341
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    cl21453
    Location:30 → 136
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6TL19.1 GenPept UniProtKB/Swiss-Prot:Q6TL19

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