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Ndufaf7 NADH:ubiquinone oxidoreductase complex assembly factor 7 [ Mus musculus (house mouse) ]

Gene ID: 73694, updated on 11-Apr-2024

Summary

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Official Symbol
Ndufaf7provided by MGI
Official Full Name
NADH:ubiquinone oxidoreductase complex assembly factor 7provided by MGI
Primary source
MGI:MGI:1920944
See related
Ensembl:ENSMUSG00000024082 AllianceGenome:MGI:1920944
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PRO1853; 2410091C18Rik
Summary
Predicted to enable enzyme binding activity and protein-arginine omega-N symmetric methyltransferase activity. Predicted to be involved in mitochondrial respiratory chain complex I assembly and peptidyl-arginine methylation, to symmetrical-dimethyl arginine. Predicted to act upstream of or within methylation. Located in mitochondrion. Is expressed in brain. Orthologous to human NDUFAF7 (NADH:ubiquinone oxidoreductase complex assembly factor 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 7.7), cortex adult (RPKM 7.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
17 E3; 17 49.67 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (79244535..79255481)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (78937106..78948052)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 26637 Neighboring gene sulfotransferase family, cytosolic, 6B, member 1 Neighboring gene STARR-seq mESC enhancer starr_43273 Neighboring gene STARR-positive B cell enhancer ABC_E8698 Neighboring gene CCAAT/enhancer binding protein zeta, opposite strand Neighboring gene STARR-positive B cell enhancer ABC_E5629 Neighboring gene CCAAT/enhancer binding protein zeta Neighboring gene protein kinase D3 Neighboring gene predicted gene, 41622 Neighboring gene STARR-seq mESC enhancer starr_43275 Neighboring gene glutaminyl-peptide cyclotransferase (glutaminyl cyclase)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The arginine methyltransferase NDUFAF7 is essential for complex I assembly and early vertebrate embryogenesis. Zurita Rendón O, et al. Hum Mol Genet, 2014 Oct 1. PMID 24838397, Free PMC Article
  2. Host genetic variation affects resistance to infection with a highly pathogenic H5N1 influenza A virus in mice. Boon AC, et al. J Virol, 2009 Oct. PMID 19706712, Free PMC Article
  3. A neurogenomics approach to gene expression analysis in the developing brain. Jensen P, et al. Brain Res Mol Brain Res, 2004 Dec 20. PMID 15582152
  4. Isolation of novel tissue-specific genes from cDNA libraries representing the individual tissue constituents of the gastrulating mouse embryo. Harrison SM, et al. Development, 1995 Aug. PMID 7671812
  5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC117993

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein-arginine omega-N symmetric methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-arginine omega-N symmetric methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial respiratory chain complex I assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial respiratory chain complex I assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in peptidyl-arginine methylation, to symmetrical-dimethyl arginine ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein arginine methyltransferase NDUFAF7, mitochondrial
Names
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex assembly factor 7
NADH dehydrogenase [ubiquinone] complex I, assembly factor 7
protein midA homolog, mitochondrial
NP_082887.2
XP_006525058.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028611.3 → NP_082887.2  protein arginine methyltransferase NDUFAF7, mitochondrial precursor

    See identical proteins and their annotated locations for NP_082887.2

    Status: VALIDATED

    Source sequence(s)
    AC154274, AK010752, CF617214, CX236822
    Consensus CDS
    CCDS28982.1
    UniProtKB/Swiss-Prot
    E9QLM6, Q8C1X3, Q9CWG8
    Related
    ENSMUSP00000024887.5, ENSMUST00000024887.6
    Conserved Domains (2) summary
    COG1565
    Location:46 → 402
    MidA; SAM-dependent methyltransferase, MidA family [General function prediction only]
    pfam02636
    Location:95 → 349
    Methyltransf_28; Putative S-adenosyl-L-methionine-dependent methyltransferase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    79244535..79255481
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006524995.2 → XP_006525058.1  protein arginine methyltransferase NDUFAF7, mitochondrial isoform X1

    Conserved Domains (1) summary
    cl17173
    Location:46 → 354
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RNA

  1. XR_385374.4 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_144760.1: Suppressed sequence

    Description
    NM_144760.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CWG8.4 GenPept UniProtKB/Swiss-Prot:Q9CWG8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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