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Calr3 calreticulin 3 [ Mus musculus (house mouse) ]

Gene ID: 73316, updated on 11-Apr-2024

Summary

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Official Symbol
Calr3provided by MGI
Official Full Name
calreticulin 3provided by MGI
Primary source
MGI:MGI:1920566
See related
Ensembl:ENSMUSG00000019732 AllianceGenome:MGI:1920566
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Crt2; cspn; 1700031L01Rik; 6330586I20Rik
Summary
Enables protein folding chaperone. Predicted to be involved in protein folding and ubiquitin-dependent ERAD pathway. Predicted to act upstream of or within cell differentiation and spermatogenesis. Predicted to be located in endoplasmic reticulum lumen and nuclear envelope. Predicted to be active in endoplasmic reticulum membrane. Is expressed in cerebral cortex and telencephalon. Orthologous to human CALR3 (calreticulin 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 18.6) and heart adult (RPKM 2.7) See more
Orthologs
human all
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Genomic context

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Location:
8 B3.3; 8 35.08 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (73178020..73197638, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (72424176..72443819, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3785 Neighboring gene STARR-seq mESC enhancer starr_21854 Neighboring gene STARR-seq mESC enhancer starr_21858 Neighboring gene Kruppel-like transcription factor 2 (lung) Neighboring gene STARR-positive B cell enhancer ABC_E8247 Neighboring gene epidermal growth factor receptor pathway substrate 15-like 1 Neighboring gene STARR-positive B cell enhancer ABC_E9731 Neighboring gene STARR-positive B cell enhancer ABC_E5020 Neighboring gene predicted gene, 46043 Neighboring gene RIKEN cDNA 1700030K09 gene Neighboring gene STARR-positive B cell enhancer ABC_E359 Neighboring gene calcium homeostasis endoplasmic reticulum protein Neighboring gene microRNA 7068

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Calsperin is a testis-specific chaperone required for sperm fertility. Ikawa M, et al. J Biol Chem, 2011 Feb 18. PMID 21131354, Free PMC Article
  2. Identification of a novel calreticulin isoform (Crt2) in human and mouse. Persson S, et al. Gene, 2002 Sep 4. PMID 12384296
  3. Protein disulfide isomerase homolog PDILT is required for quality control of sperm membrane protein ADAM3 and male fertility [corrected]. Tokuhiro K, et al. Proc Natl Acad Sci U S A, 2012 Mar 6. PMID 22357757, Free PMC Article
  4. GPI-anchored protein complex, LY6K/TEX101, is required for sperm migration into the oviduct and male fertility in mice. Fujihara Y, et al. Biol Reprod, 2014 Mar. PMID 24501175
  5. Neural progenitor genes. Germinal zone expression and analysis of genetic overlap in stem cell populations. Easterday MC, et al. Dev Biol, 2003 Dec 15. PMID 14651920

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Calsperin is a testis-specific chaperone required for sperm fertility.
    Title: Calsperin is a testis-specific chaperone required for sperm fertility.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein folding chaperone IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables unfolded protein binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum lumen ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
calreticulin-3
Names
calreticulin-2
calspeculin
calsperin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028500.3 → NP_082776.2  calreticulin-3 isoform 1 precursor

    See identical proteins and their annotated locations for NP_082776.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK006582, AK046081
    Consensus CDS
    CCDS22413.1
    UniProtKB/Swiss-Prot
    G5E827, Q9D9Q6
    UniProtKB/TrEMBL
    B1Q2L7
    Related
    ENSMUSP00000019876.6, ENSMUST00000019876.12
    Conserved Domains (1) summary
    pfam00262
    Location:23 → 315
    Calreticulin; Calreticulin family

  2. NM_029782.3 → NP_084058.2  calreticulin-3 isoform 2

    See identical proteins and their annotated locations for NP_084058.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains a distinct 5' UTR and 5' coding region, compared to variant 1. These differences result in a protein (isoform 2) with a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK046081
    Consensus CDS
    CCDS40388.1
    UniProtKB/TrEMBL
    Q8BL82
    Related
    ENSMUSP00000105601.2, ENSMUST00000109974.2
    Conserved Domains (1) summary
    pfam00262
    Location:25 → 207
    Calreticulin; Calreticulin family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    73178020..73197638 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006509761.5 → XP_006509824.1  calreticulin-3 isoform X1

    UniProtKB/TrEMBL
    B1Q2L7
    Conserved Domains (1) summary
    pfam00262
    Location:23 → 257
    Calreticulin; Calreticulin family

  2. XM_030243800.1 → XP_030099660.1  calreticulin-3 isoform X2

    Conserved Domains (1) summary
    pfam00262
    Location:25 → 149
    Calreticulin; Calreticulin family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D9Q6.2 GenPept UniProtKB/Swiss-Prot:Q9D9Q6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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