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Setd7 SET domain containing (lysine methyltransferase) 7 [ Mus musculus (house mouse) ]

Gene ID: 73251, updated on 11-Apr-2024

Summary

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Official Symbol
Setd7provided by MGI
Official Full Name
SET domain containing (lysine methyltransferase) 7provided by MGI
Primary source
MGI:MGI:1920501
See related
Ensembl:ENSMUSG00000037111 AllianceGenome:MGI:1920501
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
KMT7; Set7; H3K4MT; Set7/9; mKIAA1717; 1600028F23Rik
Summary
Enables protein-lysine N-methyltransferase activity. Involved in protein methylation. Acts upstream of or within heterochromatin organization; peptidyl-lysine methylation; and regulation of histone H3-K9 methylation. Predicted to be located in chromosome and nucleolus. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; musculature; and nervous system. Orthologous to human SETD7 (SET domain containing 7, histone lysine methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cerebellum adult (RPKM 24.0), bladder adult (RPKM 20.7) and 26 other tissues See more
Orthologs
human all
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Genomic context

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Location:
3 C; 3 22.5 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (51422740..51468519, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (51515318..51560823, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:51314972-51315081 Neighboring gene STARR-seq mESC enhancer starr_07615 Neighboring gene RAB33B, member RAS oncogene family Neighboring gene RIKEN cDNA 5031434O11 gene Neighboring gene predicted gene, 36008 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:51358072-51358308 Neighboring gene STARR-positive B cell enhancer mm9_chr3:51363442-51363743 Neighboring gene STARR-seq mESC enhancer starr_07617 Neighboring gene STARR-seq mESC enhancer starr_07618 Neighboring gene STARR-seq mESC enhancer starr_07619 Neighboring gene STARR-seq mESC enhancer starr_07620 Neighboring gene STARR-positive B cell enhancer ABC_E11183 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:51440808-51440917 Neighboring gene STARR-seq mESC enhancer starr_07621 Neighboring gene STARR-seq mESC enhancer starr_07622 Neighboring gene STARR-seq mESC enhancer starr_07623 Neighboring gene STARR-seq mESC enhancer starr_07624 Neighboring gene predicted gene, 38247 Neighboring gene microsomal glutathione S-transferase 2 Neighboring gene mastermind like transcriptional coactivator 3 Neighboring gene predicted gene, 46803

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Set7 deletion attenuates isoproterenol-induced cardiac fibrosis and delays cardiac dysfunction. Lunardon G, et al. Clin Sci (Lond), 2022 Nov 30. PMID 36285636
  2. SETD7 mediates the vascular invasion in articular cartilage and chondrocytes apoptosis in osteoarthriis. Xiaoshi J, et al. FASEB J, 2021 Mar. PMID 33617050
  3. Intestinal Epithelial Cell-Intrinsic Deletion of Setd7 Identifies Role for Developmental Pathways in Immunity to Helminth Infection. Oudhoff MJ, et al. PLoS Pathog, 2016 Sep. PMID 27598373, Free PMC Article
  4. Set7 mediated interactions regulate transcriptional networks in embryonic stem cells. Tuano NK, et al. Nucleic Acids Res, 2016 Nov 2. PMID 27439711, Free PMC Article
  5. (R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells. Barsyte-Lovejoy D, et al. Proc Natl Acad Sci U S A, 2014 Sep 2. PMID 25136132, Free PMC Article

See all (57) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Set7 deletion attenuates isoproterenol-induced cardiac fibrosis and delays cardiac dysfunction.
    Title: Set7 deletion attenuates isoproterenol-induced cardiac fibrosis and delays cardiac dysfunction.
  2. LncRNA SNHG15 regulates hypoxic-ischemic brain injury via miR-153-3p/SETD7 axis.
    Title: LncRNA SNHG15 regulates hypoxic-ischemic brain injury via miR-153-3p/SETD7 axis.
  3. Loss of SPTBN1 Suppresses Autophagy Via SETD7-mediated YAP Methylation in Hepatocellular Carcinoma Initiation and Development.
    Title: Loss of SPTBN1 Suppresses Autophagy Via SETD7-mediated YAP Methylation in Hepatocellular Carcinoma Initiation and Development.
  4. SETD7 regulates chondrocyte differentiation and glycolysis via the Hippo signaling pathway and HIF1alpha.
    Title: SETD7 regulates chondrocyte differentiation and glycolysis via the Hippo signaling pathway and HIF‑1α.
  5. IL-6 regulates the bone metabolism and inflammatory microenvironment in aging mice by inhibiting Setd7.
    Title: IL-6 regulates the bone metabolism and inflammatory microenvironment in aging mice by inhibiting Setd7.
  6. SetD7 (Set7/9) is a novel target of PPARgamma that promotes the adaptive pancreatic beta-cell glycemic response.
    Title: SetD7 (Set7/9) is a novel target of PPARγ that promotes the adaptive pancreatic β-cell glycemic response.
  7. SETD7 mediates the vascular invasion in articular cartilage and chondrocytes apoptosis in osteoarthriis.
    Title: SETD7 mediates the vascular invasion in articular cartilage and chondrocytes apoptosis in osteoarthriis.
  8. Murine peritoneal fibrosis was induced by intraperitoneal injection of methylglyoxal (MGO). SET7/9 expression was elevated in MGO-injected mice.
    Title: Inhibition of the H3K4 methyltransferase SET7/9 ameliorates peritoneal fibrosis.
  9. spinal SET7/9 may contribute to the maintenance of CIBP
    Title: Spinal SET7/9 may contribute to the maintenance of cancer-induced bone pain in mice.
  10. the methyltransferase Set9 potentiates TGF-beta signaling by targeting Smad7, an inhibitory downstream effector.
    Title: SET9-Mediated Regulation of TGF-β Signaling Links Protein Methylation to Pulmonary Fibrosis.
Submit: New GeneRIF Correction See all GeneRIFs (25)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
  
enables histone H3 methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables histone H3K4 monomethyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables p53 binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-lysine N-methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein-lysine N-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within chromatin organization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in heterochromatin organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within heterochromatin organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within heterochromatin organization ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within methylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in peptidyl-lysine dimethylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within peptidyl-lysine methylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in peptidyl-lysine methylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in peptidyl-lysine monomethylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidyl-lysine monomethylation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in protein methylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in chromosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in chromosome ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
histone-lysine N-methyltransferase SETD7
Names
H3-K4 methyltransferase
H3-K4-HMTase SETD7
SET domain-containing protein 7
histone H3-K4 methyltransferase SETD7
NP_542983.3
XP_036019246.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_080793.6 → NP_542983.3  histone-lysine N-methyltransferase SETD7

    See identical proteins and their annotated locations for NP_542983.3

    Status: VALIDATED

    Source sequence(s)
    AC102860
    Consensus CDS
    CCDS17341.1
    UniProtKB/Swiss-Prot
    Q6ZPJ6, Q80UU3, Q8C7Y6, Q8VHL1
    Related
    ENSMUSP00000043492.8, ENSMUST00000037141.9
    Conserved Domains (1) summary
    smart00317
    Location:226 → 342
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    51422740..51468519 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163353.1 → XP_036019246.1  histone-lysine N-methyltransferase SETD7 isoform X1

    Conserved Domains (1) summary
    cd10530
    Location:70 → 199
    SET_SETD7; SET domain found in SET domain-containing protein 7 (SETD7) and similar proteins

RNA

  1. XR_004941406.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VHL1.2 GenPept UniProtKB/Swiss-Prot:Q8VHL1

Gene LinkOut

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