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Tgfbrap1 transforming growth factor, beta receptor associated protein 1 [ Mus musculus (house mouse) ]

Gene ID: 73122, updated on 11-Apr-2024

Summary

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Official Symbol
Tgfbrap1provided by MGI
Official Full Name
transforming growth factor, beta receptor associated protein 1provided by MGI
Primary source
MGI:MGI:2447427
See related
Ensembl:ENSMUSG00000070939 AllianceGenome:MGI:2447427
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Trap1; 3110018K12Rik
Summary
Predicted to enable SMAD binding activity and transforming growth factor beta receptor binding activity. Predicted to be involved in several processes, including autophagy; endosomal vesicle fusion; and endosome to lysosome transport. Predicted to act upstream of or within protein transport. Part of CORVET complex. Orthologous to human TGFBRAP1 (transforming growth factor beta receptor associated protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney adult (RPKM 11.7), lung adult (RPKM 11.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 B; 1 22.13 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (43086360..43137788, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (43047200..43098712, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39633 Neighboring gene G protein-coupled receptor 45 Neighboring gene STARR-seq mESC enhancer starr_00772 Neighboring gene DnaJ (Hsp40) homolog, subfamily A, member 1 pseudogene Neighboring gene predicted gene 28782 Neighboring gene RIKEN cDNA 8430432A02 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:43155317-43155426 Neighboring gene expressed sequence AI597479 Neighboring gene STARR-seq mESC enhancer starr_00773 Neighboring gene STARR-seq mESC enhancer starr_00774 Neighboring gene four and a half LIM domains 2 Neighboring gene STARR-seq mESC enhancer starr_00775 Neighboring gene 60S ribosomal protein L29

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The TGF-β signaling modulators TRAP1/TGFBRAP1 and VPS39/Vam6/TLP are essential for early embryonic development. Messler S, et al. Immunobiology, 2011 Mar. PMID 20961651
  2. VPS39-deficiency observed in type 2 diabetes impairs muscle stem cell differentiation via altered autophagy and epigenetics. Davegårdh C, et al. Nat Commun, 2021 Apr 23. PMID 33893273, Free PMC Article
  3. Chromogranin A regulates renal function by triggering Weibel-Palade body exocytosis. Chen Y, et al. J Am Soc Nephrol, 2009 Jul. PMID 19520754, Free PMC Article
  4. The Fn14 cytoplasmic tail binds tumour-necrosis-factor-receptor-associated factors 1, 2, 3 and 5 and mediates nuclear factor-kappaB activation. Brown SA, et al. Biochem J, 2003 Apr 15. PMID 12529173, Free PMC Article
  5. Mammalian CORVET is required for fusion and conversion of distinct early endosome subpopulations. Perini ED, et al. Traffic, 2014 Dec. PMID 25266290

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. our data indicate that TRAP1 and VPS39 are nonredundant and essentially required for early embryonic development
    Title: The TGF-β signaling modulators TRAP1/TGFBRAP1 and VPS39/Vam6/TLP are essential for early embryonic development.
  2. CHGA triggered secretion of endothelin-1 from glomerular endothelial cells and TGF-beta1 from mesangial cells cocultured with glomerular endothelial cells.
    Title: Chromogranin A regulates renal function by triggering Weibel-Palade body exocytosis.
  3. The Fn14 cytoplasmic tail binds this protein and mediates nuclear factor-kappaB activation.
    Title: The Fn14 cytoplasmic tail binds tumour-necrosis-factor-receptor-associated factors 1, 2, 3 and 5 and mediates nuclear factor-kappaB activation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SMAD binding ISO
Inferred from Sequence Orthology
more info
  
enables transforming growth factor beta receptor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in autophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endosomal vesicle fusion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endosomal vesicle fusion ISO
Inferred from Sequence Orthology
more info
  
involved_in endosome to lysosome transport ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of CORVET complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in early endosome ISO
Inferred from Sequence Orthology
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
transforming growth factor-beta receptor-associated protein 1
Names
TGF beta receptor associated protein 1
TRAP-1
tansforming growth factor, beta receptor associated protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013025.3 → NP_001013043.1  transforming growth factor-beta receptor-associated protein 1

    See identical proteins and their annotated locations for NP_001013043.1

    Status: VALIDATED

    Source sequence(s)
    AC112941, BC072608, BP753627
    Consensus CDS
    CCDS14920.1
    UniProtKB/Swiss-Prot
    Q3UR70, Q8BKN4
    Related
    ENSMUSP00000092624.2, ENSMUST00000095014.8
    Conserved Domains (4) summary
    pfam00637
    Location:585 → 699
    Clathrin; Region in Clathrin and VPS
    pfam10366
    Location:448 → 550
    Vps39_1; Vacuolar sorting protein 39 domain 1
    pfam10367
    Location:738 → 846
    Vps39_2; Vacuolar sorting protein 39 domain 2
    cl02434
    Location:34 → 283
    CNH; CNH domain

  2. NM_001357299.1 → NP_001344228.1  transforming growth factor-beta receptor-associated protein 1

    Status: VALIDATED

    Source sequence(s)
    AC112941
    Consensus CDS
    CCDS14920.1
    UniProtKB/Swiss-Prot
    Q3UR70, Q8BKN4
    Related
    ENSMUSP00000140132.2, ENSMUST00000186694.7
    Conserved Domains (4) summary
    pfam00637
    Location:585 → 699
    Clathrin; Region in Clathrin and VPS
    pfam10366
    Location:448 → 550
    Vps39_1; Vacuolar sorting protein 39 domain 1
    pfam10367
    Location:738 → 846
    Vps39_2; Vacuolar sorting protein 39 domain 2
    cl02434
    Location:34 → 283
    CNH; CNH domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    43086360..43137788 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030243152.2 → XP_030099012.1  transforming growth factor-beta receptor-associated protein 1 isoform X3

    UniProtKB/Swiss-Prot
    Q3UR70, Q8BKN4
    Conserved Domains (4) summary
    pfam00637
    Location:585 → 699
    Clathrin; Region in Clathrin and VPS
    pfam10366
    Location:448 → 550
    Vps39_1; Vacuolar sorting protein 39 domain 1
    pfam10367
    Location:738 → 846
    Vps39_2; Vacuolar sorting protein 39 domain 2
    cl02434
    Location:34 → 283
    CNH; CNH domain

  2. XM_011238604.4 → XP_011236906.1  transforming growth factor-beta receptor-associated protein 1 isoform X2

    See identical proteins and their annotated locations for XP_011236906.1

    Conserved Domains (4) summary
    pfam00637
    Location:593 → 707
    Clathrin; Region in Clathrin and VPS
    pfam10366
    Location:456 → 558
    Vps39_1; Vacuolar sorting protein 39 domain 1
    pfam10367
    Location:746 → 854
    Vps39_2; Vacuolar sorting protein 39 domain 2
    cl02434
    Location:42 → 291
    CNH; CNH domain

  3. XM_036153757.1 → XP_036009650.1  transforming growth factor-beta receptor-associated protein 1 isoform X4

    Conserved Domains (3) summary
    pfam10366
    Location:28 → 130
    Vps39_1; Vacuolar sorting protein 39 domain 1
    pfam00637
    Location:165 → 279
    Clathrin; Region in Clathrin and VPS
    pfam10367
    Location:318 → 426
    Vps39_2; Vacuolar sorting protein 39 domain 2

  4. XM_006496303.4 → XP_006496366.1  transforming growth factor-beta receptor-associated protein 1 isoform X3

    See identical proteins and their annotated locations for XP_006496366.1

    UniProtKB/Swiss-Prot
    Q3UR70, Q8BKN4
    Conserved Domains (4) summary
    pfam00637
    Location:585 → 699
    Clathrin; Region in Clathrin and VPS
    pfam10366
    Location:448 → 550
    Vps39_1; Vacuolar sorting protein 39 domain 1
    pfam10367
    Location:738 → 846
    Vps39_2; Vacuolar sorting protein 39 domain 2
    cl02434
    Location:34 → 283
    CNH; CNH domain

  5. XM_006496300.4 → XP_006496363.1  transforming growth factor-beta receptor-associated protein 1 isoform X1

    Conserved Domains (4) summary
    pfam00637
    Location:594 → 708
    Clathrin; Region in Clathrin and VPS
    pfam10366
    Location:457 → 559
    Vps39_1; Vacuolar sorting protein 39 domain 1
    pfam10367
    Location:747 → 855
    Vps39_2; Vacuolar sorting protein 39 domain 2
    cl02434
    Location:43 → 292
    CNH; CNH domain

  6. XM_006496302.5 → XP_006496365.1  transforming growth factor-beta receptor-associated protein 1 isoform X3

    See identical proteins and their annotated locations for XP_006496365.1

    UniProtKB/Swiss-Prot
    Q3UR70, Q8BKN4
    Conserved Domains (4) summary
    pfam00637
    Location:585 → 699
    Clathrin; Region in Clathrin and VPS
    pfam10366
    Location:448 → 550
    Vps39_1; Vacuolar sorting protein 39 domain 1
    pfam10367
    Location:738 → 846
    Vps39_2; Vacuolar sorting protein 39 domain 2
    cl02434
    Location:34 → 283
    CNH; CNH domain

  7. XM_011238603.4 → XP_011236905.1  transforming growth factor-beta receptor-associated protein 1 isoform X2

    See identical proteins and their annotated locations for XP_011236905.1

    Conserved Domains (4) summary
    pfam00637
    Location:593 → 707
    Clathrin; Region in Clathrin and VPS
    pfam10366
    Location:456 → 558
    Vps39_1; Vacuolar sorting protein 39 domain 1
    pfam10367
    Location:746 → 854
    Vps39_2; Vacuolar sorting protein 39 domain 2
    cl02434
    Location:42 → 291
    CNH; CNH domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UR70.1 GenPept UniProtKB/Swiss-Prot:Q3UR70

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