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Rps6ka5 ribosomal protein S6 kinase, polypeptide 5 [ Mus musculus (house mouse) ]

Gene ID: 73086, updated on 21-Apr-2024

Summary

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Official Symbol
Rps6ka5provided by MGI
Official Full Name
ribosomal protein S6 kinase, polypeptide 5provided by MGI
Primary source
MGI:MGI:1920336
See related
Ensembl:ENSMUSG00000021180 AllianceGenome:MGI:1920336
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MSK1; RLPK; RLSK; MSPK1; S6K-alpha-5; 3110005L17Rik; 6330404E13Rik
Summary
Enables ATP binding activity and protein serine/threonine kinase activity. Involved in intracellular signal transduction; protein phosphorylation; and regulation of transcription, DNA-templated. Located in nucleus. Orthologous to human RPS6KA5 (ribosomal protein S6 kinase A5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cerebellum adult (RPKM 5.5), CNS E18 (RPKM 4.9) and 24 other tissues See more
Orthologs
human all
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Genomic context

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Location:
12 E; 12 50.81 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (100514692..100691693, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (100548439..100725328, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene tetratricopeptide repeat domain 7B Neighboring gene STARR-positive B cell enhancer ABC_E7167 Neighboring gene predicted gene, 53757 Neighboring gene predicted gene, 36375 Neighboring gene STARR-seq mESC enhancer starr_33048 Neighboring gene STARR-positive B cell enhancer ABC_E1450 Neighboring gene STARR-seq mESC enhancer starr_33055 Neighboring gene STARR-positive B cell enhancer mm9_chr12:101842850-101843151 Neighboring gene STARR-seq mESC enhancer starr_33059 Neighboring gene STARR-positive B cell enhancer ABC_E1451 Neighboring gene STARR-positive B cell enhancer ABC_E8499 Neighboring gene STARR-seq mESC enhancer starr_33061 Neighboring gene predicted gene 2614 Neighboring gene predicted gene, 40558 Neighboring gene predicted gene, 25801

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Hippocampal MSK1 regulates the behavioral and biological responses of mice to chronic social defeat stress: Involving of the BDNF-CREB signaling and neurogenesis. Ji CH, et al. Biochem Pharmacol, 2022 Jan. PMID 34774532
  2. Mitogen and Stress-activated Protein Kinase 1 Negatively Regulates Hippocampal Neurogenesis. Olateju OI, et al. Neuroscience, 2021 Jan 1. PMID 33246062, Free PMC Article
  3. Mitogen- and stress-activated protein kinase-1 activation is involved in melanocortin-induced BDNF expression in Neuro2a neuronal cells. Zhang W, et al. Neuroreport, 2020 Oct 7. PMID 32815825, Free PMC Article
  4. Experience Recruits MSK1 to Expand the Dynamic Range of Synapses and Enhance Cognition. Privitera L, et al. J Neurosci, 2020 Jun 10. PMID 32376781, Free PMC Article
  5. Mitogen- and Stress-Activated Protein Kinase 1 Regulates Status Epilepticus-Evoked Cell Death in the Hippocampus. Choi YS, et al. ASN Neuro, 2017 Sep-Oct. PMID 28870089, Free PMC Article

See all (108) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MSK1 is required for the beneficial synaptic and cognitive effects of enriched experience across the lifespan.
    Title: MSK1 is required for the beneficial synaptic and cognitive effects of enriched experience across the lifespan.
  2. Hippocampal MSK1 regulates the behavioral and biological responses of mice to chronic social defeat stress: Involving of the BDNF-CREB signaling and neurogenesis.
    Title: Hippocampal MSK1 regulates the behavioral and biological responses of mice to chronic social defeat stress: Involving of the BDNF-CREB signaling and neurogenesis.
  3. Dual targeting of brain region-specific kinases potentiates neurological rescue in Spinocerebellar ataxia type 1.
    Title: Dual targeting of brain region-specific kinases potentiates neurological rescue in Spinocerebellar ataxia type 1.
  4. Mitogen- and stress-activated protein kinase-1 activation is involved in melanocortin-induced BDNF expression in Neuro2a neuronal cells.
    Title: Mitogen- and stress-activated protein kinase-1 activation is involved in melanocortin-induced BDNF expression in Neuro2a neuronal cells.
  5. Mitogen and Stress-activated Protein Kinase 1 Negatively Regulates Hippocampal Neurogenesis.
    Title: Mitogen and Stress-activated Protein Kinase 1 Negatively Regulates Hippocampal Neurogenesis.
  6. Overexpression of the MSK1 Kinase in Patients With Chronic Lung Allograft Dysfunction and Its Confirmed Role in a Murine Model.
    Title: Overexpression of the MSK1 Kinase in Patients With Chronic Lung Allograft Dysfunction and Its Confirmed Role in a Murine Model.
  7. Experience Recruits MSK1 to Expand the Dynamic Range of Synapses and Enhance Cognition.
    Title: Experience Recruits MSK1 to Expand the Dynamic Range of Synapses and Enhance Cognition.
  8. These results indicate the relevance of CX3CL1 in the activation of the pro-inflammatory NF-kappaB signalling pathway through MSK1 in microglial cells.
    Title: Role of MSK1 in the Induction of NF-κB by the Chemokine CX3CL1 in Microglial Cells.
  9. These data suggest that the kinase activity of MSK1 is not directly required for several forms of synaptic plasticity or spatial learning and memory.
    Title: The Kinase Function of MSK1 Regulates BDNF Signaling to CREB and Basal Synaptic Transmission, But Is Not Required for Hippocampal Long-Term Potentiation or Spatial Memory.
  10. These data of this study provided important new insights into the mechanism by which the MAPK/MSK1 signaling cassette confers neuroprotection against excitotoxic insults.
    Title: Mitogen- and Stress-Activated Protein Kinase 1 Regulates Status Epilepticus-Evoked Cell Death in the Hippocampus.
Submit: New GeneRIF Correction See all GeneRIFs (46)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (3)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC28385

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables histone H2AS1 kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables histone H3S10 kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables histone H3S28 kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables histone H3S28 kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within inflammatory response IEA
Inferred from Electronic Annotation
more info
  
involved_in interleukin-1-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in post-translational protein modification ISO
Inferred from Sequence Orthology
more info
  
involved_in post-translational protein modification ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of postsynapse organization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of postsynapse organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ribosomal protein S6 kinase alpha-5
Names
90 kDa ribosomal protein S6 kinase 5
RSK-like protein kinase
nuclear mitogen- and stress-activated protein kinase 1
NP_001317631.1
NP_705815.1
XP_006516338.1
XP_030102809.1
XP_030102810.1
XP_036013517.1
XP_036013518.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330702.1 → NP_001317631.1  ribosomal protein S6 kinase alpha-5 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
    Source sequence(s)
    AC123705, AC159818, AK032316, AK160758, BQ174267, CX207283
    Consensus CDS
    CCDS88388.1
    UniProtKB/Swiss-Prot
    Q8C050
    UniProtKB/TrEMBL
    Q3TUH8
    Related
    ENSMUSP00000152481.2, ENSMUST00000222731.2

  2. NM_153587.3 → NP_705815.1  ribosomal protein S6 kinase alpha-5 isoform 1

    See identical proteins and their annotated locations for NP_705815.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC123705, AC159818, AK032316, AK160758, AY341873, BQ174267, CX207283
    Consensus CDS
    CCDS26107.1
    UniProtKB/Swiss-Prot
    Q8C050, Q8CI92
    Related
    ENSMUSP00000042987.7, ENSMUST00000043599.7
    Conserved Domains (3) summary
    smart00220
    Location:48 → 317
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14179
    Location:417 → 791
    STKc_MSK1_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 1
    cl21453
    Location:47 → 379
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    100514692..100691693 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006516275.5 → XP_006516338.1  ribosomal protein S6 kinase alpha-5 isoform X1

    Conserved Domains (2) summary
    cd14179
    Location:393 → 702
    STKc_MSK1_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 1
    cl21453
    Location:34 → 355
    PKc_like; Protein Kinases, catalytic domain

  2. XM_036157624.1 → XP_036013517.1  ribosomal protein S6 kinase alpha-5 isoform X2

    Conserved Domains (2) summary
    cd14179
    Location:389 → 698
    STKc_MSK1_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 1
    cl21453
    Location:47 → 351
    PKc_like; Protein Kinases, catalytic domain

  3. XM_030246950.2 → XP_030102810.1  ribosomal protein S6 kinase alpha-5 isoform X3

    UniProtKB/TrEMBL
    Q3TUH8
    Conserved Domains (2) summary
    cd14179
    Location:199 → 508
    STKc_MSK1_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 1
    cl21453
    Location:1 → 161
    PKc_like; Protein Kinases, catalytic domain

  4. XM_036157625.1 → XP_036013518.1  ribosomal protein S6 kinase alpha-5 isoform X3

    UniProtKB/TrEMBL
    Q3TUH8
    Conserved Domains (2) summary
    cd14179
    Location:199 → 508
    STKc_MSK1_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 1
    cl21453
    Location:1 → 161
    PKc_like; Protein Kinases, catalytic domain

  5. XM_030246949.2 → XP_030102809.1  ribosomal protein S6 kinase alpha-5 isoform X3

    UniProtKB/TrEMBL
    Q3TUH8
    Conserved Domains (2) summary
    cd14179
    Location:199 → 508
    STKc_MSK1_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 1
    cl21453
    Location:1 → 161
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C050.2 GenPept UniProtKB/Swiss-Prot:Q8C050

Gene LinkOut

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