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B3gat3 beta-1,3-glucuronyltransferase 3 [ Mus musculus (house mouse) ]

Gene ID: 72727, updated on 5-Mar-2024

Summary

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Official Symbol
B3gat3provided by MGI
Official Full Name
beta-1,3-glucuronyltransferase 3provided by MGI
Primary source
MGI:MGI:1919977
See related
Ensembl:ENSMUSG00000071649 AllianceGenome:MGI:1919977
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2810405M13Rik
Summary
Predicted to enable galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity and protein phosphatase activator activity. Predicted to be involved in several processes, including chondroitin sulfate proteoglycan biosynthetic process; glycosaminoglycan biosynthetic process; and positive regulation of intracellular protein transport. Predicted to act upstream of or within dermatan sulfate proteoglycan biosynthetic process and heparan sulfate proteoglycan biosynthetic process. Predicted to be located in cis-Golgi network. Predicted to be active in Golgi membrane. Is expressed in several structures, including cranium; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in Larsen-like syndrome B3GAT3 type. Orthologous to human B3GAT3 (beta-1,3-glucuronyltransferase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 58.2), cerebellum adult (RPKM 55.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
19 A; 19 6.03 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (8897740..8904600)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (8920374..8927236)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:8967434-8967543 Neighboring gene STARR-positive B cell enhancer ABC_E4265 Neighboring gene integrator complex subunit 5 Neighboring gene alpha glucosidase 2 alpha neutral subunit Neighboring gene STARR-seq mESC enhancer starr_45501 Neighboring gene predicted gene, 36629 Neighboring gene echinoderm microtubule associated protein like 3 Neighboring gene rod outer segment membrane protein 1 Neighboring gene predicted gene 10353 Neighboring gene STARR-positive B cell enhancer ABC_E5684 Neighboring gene metastasis-associated gene family, member 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mice deficient in glucuronyltransferase-I. Izumikawa T, et al. Prog Mol Biol Transl Sci, 2010. PMID 20807639
  2. Impairment of embryonic cell division and glycosaminoglycan biosynthesis in glucuronyltransferase-I-deficient mice. Izumikawa T, et al. J Biol Chem, 2010 Apr 16. PMID 20164174, Free PMC Article
  3. Specific enzyme complex of beta-1,4-galactosyltransferase-II and glucuronyltransferase-P facilitates biosynthesis of N-linked human natural killer-1 (HNK-1) carbohydrate. Kouno T, et al. J Biol Chem, 2011 Sep 9. PMID 21771787, Free PMC Article
  4. Molecular cloning and expression of glucuronyltransferase I involved in the biosynthesis of the glycosaminoglycan-protein linkage region of proteoglycans. Kitagawa H, et al. J Biol Chem, 1998 Mar 20. PMID 9506957
  5. Faulty initiation of proteoglycan synthesis causes cardiac and joint defects. Baasanjav S, et al. Am J Hum Genet, 2011 Jul 15. PMID 21763480, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables glucuronosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein phosphatase activator activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chondroitin sulfate proteoglycan biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within chondroitin sulfate proteoglycan biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within dermatan sulfate proteoglycan biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in glycosaminoglycan biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in glycosaminoglycan biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in glycosaminoglycan biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within heparan sulfate proteoglycan biosynthetic process ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in heparan sulfate proteoglycan biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of catalytic activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of intracellular protein transport ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cis-Golgi network ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3
Names
UDP-GlcUA:Gal beta-1,3-Gal-R glucuronyltransferase
glcAT-I
glcUAT-I
glucuronosyltransferase I
glucuronyltransferase I
NP_077218.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024256.2 → NP_077218.1  galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3

    See identical proteins and their annotated locations for NP_077218.1

    Status: VALIDATED

    Source sequence(s)
    BC004038
    Consensus CDS
    CCDS29558.1
    UniProtKB/Swiss-Prot
    P58158
    UniProtKB/TrEMBL
    Q3UJY2, Q3UN75
    Related
    ENSMUSP00000093962.6, ENSMUST00000096243.7
    Conserved Domains (1) summary
    cd00218
    Location:75 → 313
    GlcAT-I; Beta1,3-glucuronyltransferase I (GlcAT-I) is involved in the initial steps of proteoglycan synthesis

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    8897740..8904600
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_003952823.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P58158.1 GenPept UniProtKB/Swiss-Prot:P58158

Gene LinkOut

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