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Hpf1 histone PARylation factor 1 [ Mus musculus (house mouse) ]

Gene ID: 72612, updated on 30-Apr-2024

Summary

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Official Symbol
Hpf1provided by MGI
Official Full Name
histone PARylation factor 1provided by MGI
Primary source
MGI:MGI:1919862
See related
Ensembl:ENSMUSG00000038005 AllianceGenome:MGI:1919862
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C4orf27; 2700029M09Rik; C230006B22Rik
Summary
Predicted to enable chromatin binding activity; histone binding activity; and poly-ADP-D-ribose binding activity. Predicted to be involved in double-strand break repair; peptidyl-serine ADP-ribosylation; and regulation of protein modification process. Predicted to act upstream of or within DNA repair. Predicted to be located in chromatin and site of DNA damage. Predicted to be active in nucleus. Orthologous to human HPF1 (histone PARylation factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E14 (RPKM 10.8), CNS E11.5 (RPKM 10.1) and 22 other tissues See more
Orthologs
human all
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Genomic context

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See Hpf1 in Genome Data Viewer
Location:
8 B3.1; 8 30.9 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (61342533..61360615)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (60890392..60907580)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STAM binding protein, pseudogene 2 Neighboring gene STARR-seq mESC enhancer starr_21566 Neighboring gene predicted gene, 23329 Neighboring gene STARR-seq mESC enhancer starr_21571 Neighboring gene STARR-seq mESC enhancer starr_21573 Neighboring gene STARR-positive B cell enhancer mm9_chr8:63369016-63369317 Neighboring gene chloride channel, voltage-sensitive 3 Neighboring gene predicted gene, 18394 Neighboring gene STARR-seq mESC enhancer starr_21578 Neighboring gene STARR-positive B cell enhancer ABC_E10500 Neighboring gene STARR-positive B cell enhancer ABC_E6639 Neighboring gene NIMA (never in mitosis gene a)-related expressed kinase 1 Neighboring gene STARR-positive B cell enhancer ABC_E11383

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. HPF1 remodels the active site of PARP1 to enable the serine ADP-ribosylation of histones. Sun FH, et al. Nat Commun, 2021 Feb 15. PMID 33589610, Free PMC Article
  2. Accelerating functional gene discovery in osteoarthritis. Butterfield NC, et al. Nat Commun, 2021 Jan 20. PMID 33473114, Free PMC Article
  3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  4. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
  5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. HPF1 remodels the active site of PARP1 to enable the serine ADP-ribosylation of histones.
    Title: HPF1 remodels the active site of PARP1 to enable the serine ADP-ribosylation of histones.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
  
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone binding ISO
Inferred from Sequence Orthology
more info
  
enables poly-ADP-D-ribose binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein ADP-ribosyltransferase-substrate adaptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in DNA damage response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
  
involved_in DNA repair ISO
Inferred from Sequence Orthology
more info
  
involved_in DNA repair-dependent chromatin remodeling ISO
Inferred from Sequence Orthology
more info
  
involved_in double-strand break repair ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein ADP-ribosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of protein ADP-ribosylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of chromatin ISO
Inferred from Sequence Orthology
more info
  
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
is_active_in site of DNA damage ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
histone PARylation factor 1
Names
UPF0609 protein C4orf27 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001379027.1 → NP_001365956.1  histone PARylation factor 1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) encodes the longest isoform (3).
    Source sequence(s)
    AC114920
    Conserved Domains (1) summary
    pfam10228
    Location:78 → 338
    DUF2228; Uncharacterized conserved protein (DUF2228)

  2. NM_001379028.1 → NP_001365957.1  histone PARylation factor 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC114920
    Conserved Domains (1) summary
    pfam10228
    Location:16 → 128
    DUF2228; Uncharacterized conserved protein (DUF2228)

  3. NM_028299.3 → NP_082575.1  histone PARylation factor 1 isoform 1

    See identical proteins and their annotated locations for NP_082575.1

    Status: VALIDATED

    Source sequence(s)
    AC114920
    Consensus CDS
    CCDS52553.1
    UniProtKB/Swiss-Prot
    Q8CFE2
    Related
    ENSMUSP00000047235.9, ENSMUST00000037190.15
    Conserved Domains (1) summary
    pfam10228
    Location:78 → 328
    DUF2228; Uncharacterized conserved protein (DUF2228)

RNA

  1. NR_151662.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC114920
    Related
    ENSMUST00000146863.2

  2. NR_166421.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC114920
    Related
    ENSMUST00000149267.8

  3. NR_166422.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC114920

  4. NR_166424.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC114920

  5. NR_166425.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC114920

  6. NR_166426.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC114920

  7. NR_166427.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC114920

  8. NR_166428.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC114920

  9. NR_166429.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC114920

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    61342533..61360615
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036154312.1 → XP_036010205.1  histone PARylation factor 1 isoform X3

    Conserved Domains (1) summary
    pfam10228
    Location:1 → 169
    DUF2228; Uncharacterized conserved protein (DUF2228)

  2. XM_036154311.1 → XP_036010204.1  histone PARylation factor 1 isoform X3

    Conserved Domains (1) summary
    pfam10228
    Location:1 → 169
    DUF2228; Uncharacterized conserved protein (DUF2228)

  3. XM_006509512.5 → XP_006509575.1  histone PARylation factor 1 isoform X2

    Conserved Domains (1) summary
    pfam10228
    Location:79 → 320
    DUF2228; Uncharacterized conserved protein (DUF2228)

  4. XM_006509510.5 → XP_006509573.1  histone PARylation factor 1 isoform X1

    Conserved Domains (1) summary
    pfam10228
    Location:79 → 330
    DUF2228; Uncharacterized conserved protein (DUF2228)

RNA

  1. XR_378914.5 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CFE2.1 GenPept UniProtKB/Swiss-Prot:Q8CFE2

Gene LinkOut

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