Ppme1 protein phosphatase methylesterase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ppme1provided by MGI
Official Full Name: protein phosphatase methylesterase 1provided by MGI
Primary source: MGI:MGI:1919840
See related: Ensembl:ENSMUSG00000030718 AllianceGenome:MGI:1919840
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Pme1; PME-1; 1110069N17Rik; 2700017M01Rik
Summary: Predicted to enable protein C-terminal methylesterase activity; protein kinase binding activity; and protein phosphatase 2A binding activity. Predicted to be involved in protein demethylation. Is expressed in several structures, including alimentary system; clavicle; ganglia; lower urinary tract; and nasal cavity epithelium. Orthologous to human PPME1 (protein phosphatase methylesterase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in cortex adult (RPKM 60.3), frontal lobe adult (RPKM 53.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 E2; 7 54.35 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (99975944..100021103, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (100326737..100371896, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Transcriptome analysis revealed that PME-1 suppresses inflammatory signaling, activates PI3K/Akt signaling, and promotes epithelial-mesenchymal transition.
Title: Transcriptome analysis revealed that PME-1 suppresses inflammatory signaling, activates PI3K/Akt signaling, and promotes epithelial-mesenchymal transition.
Hyperphosphorylation of Tau Due to the Interference of Protein Phosphatase Methylesterase-1 Overexpression by MiR-125b-5p in Melatonin Receptor Knockout Mice.
Title: Hyperphosphorylation of Tau Due to the Interference of Protein Phosphatase Methylesterase-1 Overexpression by MiR-125b-5p in Melatonin Receptor Knockout Mice.
Reduced Expression of the PP2A Methylesterase, PME-1, or the PP2A Methyltransferase, LCMT-1, Alters Sensitivity to Beta-Amyloid-Induced Cognitive and Electrophysiological Impairments in Mice.
Title: Reduced Expression of the PP2A Methylesterase, PME-1, or the PP2A Methyltransferase, LCMT-1, Alters Sensitivity to Beta-Amyloid-Induced Cognitive and Electrophysiological Impairments in Mice.
protects protein phosphatase 2A from ubiquitin/proteasome degradation
Title: Protein Phosphatase Methyl-Esterase PME-1 Protects Protein Phosphatase 2A from Ubiquitin/Proteasome Degradation.
Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors.
Title: Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors.
PME-1 plays a critical role in differentiation of neuroblastoma cells.
Title: Regulation of protein phosphatase 2A methylation by LCMT1 and PME-1 plays a critical role in differentiation of neuroblastoma cells.
targeted disruption of the PME-1 gene causes perinatal lethality in mice, a phenotype that correlates with a virtually complete loss of the demethylated form of PP2A in the nervous system and peripheral tissues
Title: Targeted disruption of the PME-1 gene causes loss of demethylated PP2A and perinatal lethality in mice.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables carboxylic ester hydrolase activity	IEA Inferred from Electronic Annotation more info
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables lncRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein C-terminal methylesterase activity	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein methylesterase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein phosphatase 2A binding	ISO Inferred from Sequence Orthology more info
enables protein phosphatase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in protein demethylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein demethylation	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in type I interferon production	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: protein phosphatase methylesterase 1

NP_082568.1

EC 3.1.1.89

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_028292.2 → NP_082568.1 protein phosphatase methylesterase 1

See identical proteins and their annotated locations for NP_082568.1

Status: PROVISIONAL

Source sequence(s)

AC122269

Consensus CDS

CCDS40036.1

UniProtKB/Swiss-Prot

Q3U392, Q3UJX8, Q3UKE0, Q8BVQ5, Q8K311, Q91YR8, Q9CSP7

Related

ENSMUSP00000032963.9, ENSMUST00000032963.10

Conserved Domains (3) summary

COG0596
Location:66 → 370

MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]

pfam12695
Location:78 → 195

Abhydrolase_5; Alpha/beta hydrolase family

cl17036
Location:270 → 306

SH3; Src Homology 3 domain superfamily