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Naalad2 N-acetylated alpha-linked acidic dipeptidase 2 [ Mus musculus (house mouse) ]

Gene ID: 72560, updated on 16-Apr-2024

Summary

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Official Symbol
Naalad2provided by MGI
Official Full Name
N-acetylated alpha-linked acidic dipeptidase 2provided by MGI
Primary source
MGI:MGI:1919810
See related
Ensembl:ENSMUSG00000043943 AllianceGenome:MGI:1919810
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GCP3; Folh1b; GCPIII; D9Ertd285e; NAADALASE2; NAALADASE2; 2700022G20Rik
Summary
Enables N-formylglutamate deformylase activity and carboxypeptidase activity. Acts upstream of or within neurotransmitter catabolic process and proteolysis. Is integral component of membrane. Orthologous to human NAALAD2 (N-acetylated alpha-linked acidic dipeptidase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in bladder adult (RPKM 3.8), testis adult (RPKM 1.8) and 17 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 A2; 9 7.02 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (18233247..18308834, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (18321951..18397538, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_23416 Neighboring gene predicted gene, 51667 Neighboring gene predicted gene 7692 Neighboring gene cysteine and histidine rich domain containing 1 Neighboring gene amyloid beta (A4) precursor protein-binding, family B, member 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_23417 Neighboring gene upstream binding transcription factor, RNA polymerase I-like 1 pseudogene Neighboring gene upstream binding transcription factor, RNA polymerase I-like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The cloning and characterization of a second brain enzyme with NAAG peptidase activity. Bzdega T, et al. J Neurochem, 2004 May. PMID 15086519
  2. Molecular identification of β-citrylglutamate hydrolase as glutamate carboxypeptidase 3. Collard F, et al. J Biol Chem, 2011 Nov 4. PMID 21908619, Free PMC Article
  3. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
  4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Deletion of glutamate carboxypeptidase II (GCPII), but not GCPIII, provided long-term benefits in mice with traumatic brain injury.
    Title: Deletion of glutamate carboxypeptidase II (GCPII), but not GCPIII, provided long-term benefits in mice with traumatic brain injury.
  2. analysis of GCP2 and GCP3; beta-citrylglutamate hydrolase is glutamate carboxypeptidase 3
    Title: Molecular identification of β-citrylglutamate hydrolase as glutamate carboxypeptidase 3.
  3. cloning and characterization of a mouse enzyme that is homologous to an enzyme identified in a human lung carcinoma.
    Title: The cloning and characterization of a second brain enzyme with NAAG peptidase activity.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC124348, MGC124349

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables N-formylglutamate deformylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables carboxypeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables carboxypeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables dipeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metallocarboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in carboxylic acid catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in organic substance catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within proteolysis IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
N-acetylated-alpha-linked acidic dipeptidase 2
Names
N-acetylaspartylglutamate peptidase II
N-acetylated-alpha-linked acidic dipeptidase II
NAAG-peptidase II
NAALADase II
glutamate carboxypeptidase III
NP_001344328.1
NP_001344329.1
NP_082555.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357399.1 → NP_001344328.1  N-acetylated-alpha-linked acidic dipeptidase 2 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AC154699, AC162941, AK161457
    Consensus CDS
    CCDS90504.1
    UniProtKB/TrEMBL
    G3UWC2, Q3TTB7
    Related
    ENSMUSP00000130752.2, ENSMUST00000172171.8
    Conserved Domains (4) summary
    cd08022
    Location:376 → 623
    M28_PSMA_like; M28 Zn-peptidase prostate-specific membrane antigen
    cd02121
    Location:148 → 374
    PA_GCPII_like; PA_GCPII_like: Protease-associated domain containing protein, glutamate carboxypeptidase II (GCPII)-like. This group contains various PA domain-containing proteins similar to GCPII including, GCPIII (NAALADase2) and NAALADase L. These proteins belong to ...
    pfam04253
    Location:660 → 771
    TFR_dimer; Transferrin receptor-like dimerisation domain
    cl14876
    Location:86 → 142
    Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42

  2. NM_001357400.1 → NP_001344329.1  N-acetylated-alpha-linked acidic dipeptidase 2 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AC154699, AC162941, AK135653
    Consensus CDS
    CCDS90504.1
    UniProtKB/TrEMBL
    G3UWC2, Q3TTB7
    Related
    ENSMUSP00000001826.9, ENSMUST00000001826.15
    Conserved Domains (4) summary
    cd08022
    Location:376 → 623
    M28_PSMA_like; M28 Zn-peptidase prostate-specific membrane antigen
    cd02121
    Location:148 → 374
    PA_GCPII_like; PA_GCPII_like: Protease-associated domain containing protein, glutamate carboxypeptidase II (GCPII)-like. This group contains various PA domain-containing proteins similar to GCPII including, GCPIII (NAALADase2) and NAALADase L. These proteins belong to ...
    pfam04253
    Location:660 → 771
    TFR_dimer; Transferrin receptor-like dimerisation domain
    cl14876
    Location:86 → 142
    Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42

  3. NM_028279.4 → NP_082555.2  N-acetylated-alpha-linked acidic dipeptidase 2 isoform b

    See identical proteins and their annotated locations for NP_082555.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a.
    Source sequence(s)
    AC154699, AK133611
    Consensus CDS
    CCDS52728.1
    UniProtKB/Swiss-Prot
    Q80YF8, Q9CZR2
    UniProtKB/TrEMBL
    Q32MS9, Q3UZV6
    Related
    ENSMUSP00000128674.2, ENSMUST00000166825.8
    Conserved Domains (4) summary
    cd08022
    Location:338 → 585
    M28_PSMA_like; M28 Zn-peptidase prostate-specific membrane antigen
    cd02121
    Location:110 → 336
    PA_GCPII_like; PA_GCPII_like: Protease-associated domain containing protein, glutamate carboxypeptidase II (GCPII)-like. This group contains various PA domain-containing proteins similar to GCPII including, GCPIII (NAALADase2) and NAALADase L. These proteins belong to ...
    pfam04253
    Location:622 → 736
    TFR_dimer; Transferrin receptor-like dimerization domain
    cl14876
    Location:48 → 104
    Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    18233247..18308834 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CZR2.2 GenPept UniProtKB/Swiss-Prot:Q9CZR2

Gene LinkOut

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