U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Fryl FRY like transcription coactivator [ Mus musculus (house mouse) ]

Gene ID: 72313, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
Frylprovided by MGI
Official Full Name
FRY like transcription coactivatorprovided by MGI
Primary source
MGI:MGI:1919563
See related
Ensembl:ENSMUSG00000070733 AllianceGenome:MGI:1919563
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA0826; 2010313D22Rik; 2310004H21Rik; 2510002A14Rik; 9030227G01Rik
Summary
Predicted to be involved in cell morphogenesis and neuron projection development. Predicted to be active in cell cortex and site of polarized growth. Is expressed in brain; retina nuclear layer; salivary gland; and tooth. Orthologous to human FRYL (FRY like transcription coactivator). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 7.6), colon adult (RPKM 7.0) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Fryl in Genome Data Viewer
Location:
5 C3.2; 5 38.44 cM
Exon count:
69
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (73177534..73414042, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (73020191..73256699, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 10 (sodium/bile acid cotransporter family), member 4 Neighboring gene zygote arrest 1, pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E3583 Neighboring gene RIKEN cDNA 1700071G01 gene Neighboring gene STARR-positive B cell enhancer ABC_E6338 Neighboring gene STARR-positive B cell enhancer ABC_E1302 Neighboring gene STARR-positive B cell enhancer ABC_E124 Neighboring gene RIKEN cDNA 1700025M24 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:73656832-73657076 Neighboring gene predicted gene, 57841 Neighboring gene STARR-seq mESC enhancer starr_13383 Neighboring gene predicted gene, 40316

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Fryl deficiency is associated with defective kidney development and function in mice. Byun YS, et al. Exp Biol Med (Maywood), 2018 Mar. PMID 29409347, Free PMC Article
  2. Gene-trap mutagenesis using Mol/MSM-1 embryonic stem cells from MSM/Ms mice. Nakahara M, et al. Mamm Genome, 2013 Jun. PMID 23604909
  3. Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2002 Oct 31. PMID 12465718
  4. Placentation defects are highly prevalent in embryonic lethal mouse mutants. Perez-Garcia V, et al. Nature, 2018 Mar 22. PMID 29539633, Free PMC Article
  5. Gene expression in the developing mouse retina by EST sequencing and microarray analysis. Mu X, et al. Nucleic Acids Res, 2001 Dec 15. PMID 11812828, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Fryl protein is required for normal development and functional maintenance of kidney in mice.
    Title: Fryl deficiency is associated with defective kidney development and function in mice.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2) 
  • Endonuclease-mediated (2) 

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in cell morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neuron projection development IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cell cortex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in site of polarized growth IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
protein furry homolog-like
Names
furry homolog-like

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028194.2 → NP_082470.2  protein furry homolog-like

    See identical proteins and their annotated locations for NP_082470.2

    Status: VALIDATED

    Source sequence(s)
    AC108848, AK164590, AW489087, BC051118, BE650071, CD350880, CD550190, CD741721, CJ044706
    Consensus CDS
    CCDS19337.2
    UniProtKB/TrEMBL
    F8VQ05
    Related
    ENSMUSP00000098687.6, ENSMUST00000101127.12
    Conserved Domains (3) summary
    pfam14222
    Location:117 → 649
    MOR2-PAG1_N; Cell morphogenesis N-terminal
    pfam14225
    Location:2002 → 2255
    MOR2-PAG1_C; Cell morphogenesis C-terminal
    pfam14228
    Location:687 → 1860
    MOR2-PAG1_mid; Cell morphogenesis central region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    73177534..73414042 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006504150.4 → XP_006504213.1  protein furry homolog-like isoform X17

    Conserved Domains (3) summary
    pfam14222
    Location:117 → 649
    MOR2-PAG1_N; Cell morphogenesis N-terminal
    pfam14225
    Location:2002 → 2255
    MOR2-PAG1_C; Cell morphogenesis C-terminal
    pfam14228
    Location:687 → 1860
    MOR2-PAG1_mid; Cell morphogenesis central region

  2. XM_006504148.5 → XP_006504211.1  protein furry homolog-like isoform X16

    See identical proteins and their annotated locations for XP_006504211.1

    Conserved Domains (3) summary
    pfam14228
    Location:702 → 1875
    MOR2-PAG1_mid; Cell morphogenesis central region
    pfam14222
    Location:117 → 664
    MOR2-PAG1_N; Cell morphogenesis N-terminal
    pfam14225
    Location:2017 → 2270
    MOR2-PAG1_C; Cell morphogenesis C-terminal

  3. XM_030254825.2 → XP_030110685.1  protein furry homolog-like isoform X17

    Conserved Domains (3) summary
    pfam14222
    Location:117 → 649
    MOR2-PAG1_N; Cell morphogenesis N-terminal
    pfam14225
    Location:2002 → 2255
    MOR2-PAG1_C; Cell morphogenesis C-terminal
    pfam14228
    Location:687 → 1860
    MOR2-PAG1_mid; Cell morphogenesis central region

  4. XM_006504149.5 → XP_006504212.1  protein furry homolog-like isoform X16

    See identical proteins and their annotated locations for XP_006504212.1

    Conserved Domains (3) summary
    pfam14228
    Location:702 → 1875
    MOR2-PAG1_mid; Cell morphogenesis central region
    pfam14222
    Location:117 → 664
    MOR2-PAG1_N; Cell morphogenesis N-terminal
    pfam14225
    Location:2017 → 2270
    MOR2-PAG1_C; Cell morphogenesis C-terminal

  5. XM_036165519.1 → XP_036021412.1  protein furry homolog-like isoform X16

    Conserved Domains (3) summary
    pfam14228
    Location:702 → 1875
    MOR2-PAG1_mid; Cell morphogenesis central region
    pfam14222
    Location:117 → 664
    MOR2-PAG1_N; Cell morphogenesis N-terminal
    pfam14225
    Location:2017 → 2270
    MOR2-PAG1_C; Cell morphogenesis C-terminal

  6. XM_006504152.5 → XP_006504215.1  protein furry homolog-like isoform X19

    Conserved Domains (3) summary
    pfam14222
    Location:213 → 745
    MOR2-PAG1_N; Cell morphogenesis N-terminal
    pfam14225
    Location:2096 → 2349
    MOR2-PAG1_C; Cell morphogenesis C-terminal
    pfam14228
    Location:783 → 1954
    MOR2-PAG1_mid; Cell morphogenesis central region

  7. XM_006504145.5 → XP_006504208.1  protein furry homolog-like isoform X13

    Conserved Domains (3) summary
    pfam14222
    Location:213 → 745
    MOR2-PAG1_N; Cell morphogenesis N-terminal
    pfam14225
    Location:2098 → 2351
    MOR2-PAG1_C; Cell morphogenesis C-terminal
    pfam14228
    Location:783 → 1956
    MOR2-PAG1_mid; Cell morphogenesis central region

  8. XM_006504144.5 → XP_006504207.1  protein furry homolog-like isoform X12

    Conserved Domains (3) summary
    pfam14222
    Location:213 → 745
    MOR2-PAG1_N; Cell morphogenesis N-terminal
    pfam14225
    Location:2098 → 2351
    MOR2-PAG1_C; Cell morphogenesis C-terminal
    pfam14228
    Location:783 → 1956
    MOR2-PAG1_mid; Cell morphogenesis central region

  9. XM_036165518.1 → XP_036021411.1  protein furry homolog-like isoform X11

    Conserved Domains (3) summary
    pfam14228
    Location:798 → 1969
    MOR2-PAG1_mid; Cell morphogenesis central region
    pfam14222
    Location:213 → 760
    MOR2-PAG1_N; Cell morphogenesis N-terminal
    pfam14225
    Location:2111 → 2364
    MOR2-PAG1_C; Cell morphogenesis C-terminal

  10. XM_006504141.5 → XP_006504204.1  protein furry homolog-like isoform X6

    Conserved Domains (3) summary
    pfam14222
    Location:213 → 760
    MOR2-PAG1_N; Cell morphogenesis N-terminal
    pfam14225
    Location:2111 → 2364
    MOR2-PAG1_C; Cell morphogenesis C-terminal
    pfam14228
    Location:798 → 1969
    MOR2-PAG1_mid; Cell morphogenesis central region

  11. XM_036165517.1 → XP_036021410.1  protein furry homolog-like isoform X10

    Conserved Domains (3) summary
    pfam14228
    Location:798 → 1970
    MOR2-PAG1_mid; Cell morphogenesis central region
    pfam14222
    Location:213 → 760
    MOR2-PAG1_N; Cell morphogenesis N-terminal
    pfam14225
    Location:2112 → 2365
    MOR2-PAG1_C; Cell morphogenesis C-terminal

  12. XM_006504139.5 → XP_006504202.1  protein furry homolog-like isoform X3

    Conserved Domains (3) summary
    pfam14222
    Location:213 → 760
    MOR2-PAG1_N; Cell morphogenesis N-terminal
    pfam14225
    Location:2112 → 2365
    MOR2-PAG1_C; Cell morphogenesis C-terminal
    pfam14228
    Location:798 → 1970
    MOR2-PAG1_mid; Cell morphogenesis central region

  13. XM_030254824.2 → XP_030110684.1  protein furry homolog-like isoform X9

    Conserved Domains (3) summary
    pfam14222
    Location:213 → 760
    MOR2-PAG1_N; Cell morphogenesis N-terminal
    pfam14225
    Location:2112 → 2365
    MOR2-PAG1_C; Cell morphogenesis C-terminal
    pfam14228
    Location:798 → 1970
    MOR2-PAG1_mid; Cell morphogenesis central region

  14. XM_036165516.1 → XP_036021409.1  protein furry homolog-like isoform X5

    Conserved Domains (3) summary
    pfam14228
    Location:798 → 1970
    MOR2-PAG1_mid; Cell morphogenesis central region
    pfam14222
    Location:213 → 760
    MOR2-PAG1_N; Cell morphogenesis N-terminal
    pfam14225
    Location:2112 → 2365
    MOR2-PAG1_C; Cell morphogenesis C-terminal

  15. XM_006504138.5 → XP_006504201.1  protein furry homolog-like isoform X2

    Conserved Domains (3) summary
    pfam14222
    Location:213 → 760
    MOR2-PAG1_N; Cell morphogenesis N-terminal
    pfam14225
    Location:2112 → 2365
    MOR2-PAG1_C; Cell morphogenesis C-terminal
    pfam14228
    Location:798 → 1970
    MOR2-PAG1_mid; Cell morphogenesis central region

  16. XM_006504140.5 → XP_006504203.1  protein furry homolog-like isoform X4

    Conserved Domains (3) summary
    pfam14222
    Location:213 → 760
    MOR2-PAG1_N; Cell morphogenesis N-terminal
    pfam14225
    Location:2113 → 2366
    MOR2-PAG1_C; Cell morphogenesis C-terminal
    pfam14228
    Location:798 → 1971
    MOR2-PAG1_mid; Cell morphogenesis central region

  17. XM_006504142.5 → XP_006504205.1  protein furry homolog-like isoform X7

    Conserved Domains (3) summary
    pfam14222
    Location:213 → 760
    MOR2-PAG1_N; Cell morphogenesis N-terminal
    pfam14225
    Location:2113 → 2366
    MOR2-PAG1_C; Cell morphogenesis C-terminal
    pfam14228
    Location:798 → 1971
    MOR2-PAG1_mid; Cell morphogenesis central region

  18. XM_006504137.5 → XP_006504200.1  protein furry homolog-like isoform X1

    Conserved Domains (3) summary
    pfam14222
    Location:213 → 760
    MOR2-PAG1_N; Cell morphogenesis N-terminal
    pfam14225
    Location:2113 → 2366
    MOR2-PAG1_C; Cell morphogenesis C-terminal
    pfam14228
    Location:798 → 1971
    MOR2-PAG1_mid; Cell morphogenesis central region

  19. XM_017321111.3 → XP_017176600.1  protein furry homolog-like isoform X14

    Conserved Domains (3) summary
    pfam14222
    Location:213 → 745
    MOR2-PAG1_N; Cell morphogenesis N-terminal
    pfam14225
    Location:2098 → 2351
    MOR2-PAG1_C; Cell morphogenesis C-terminal
    pfam14228
    Location:783 → 1956
    MOR2-PAG1_mid; Cell morphogenesis central region

  20. XM_006504143.5 → XP_006504206.1  protein furry homolog-like isoform X8

    Conserved Domains (3) summary
    pfam14222
    Location:213 → 760
    MOR2-PAG1_N; Cell morphogenesis N-terminal
    pfam14225
    Location:2113 → 2366
    MOR2-PAG1_C; Cell morphogenesis C-terminal
    pfam14228
    Location:798 → 1971
    MOR2-PAG1_mid; Cell morphogenesis central region

  21. XM_006504146.5 → XP_006504209.1  protein furry homolog-like isoform X15

    Conserved Domains (3) summary
    pfam14222
    Location:170 → 717
    MOR2-PAG1_N; Cell morphogenesis N-terminal
    pfam14225
    Location:2070 → 2323
    MOR2-PAG1_C; Cell morphogenesis C-terminal
    pfam14228
    Location:755 → 1928
    MOR2-PAG1_mid; Cell morphogenesis central region

  22. XM_036165520.1 → XP_036021413.1  protein furry homolog-like isoform X18

    UniProtKB/TrEMBL
    Q8CHD0
    Conserved Domains (2) summary
    pfam14228
    Location:5 → 690
    MOR2-PAG1_mid; Cell morphogenesis central region
    pfam14225
    Location:832 → 1085
    MOR2-PAG1_C; Cell morphogenesis C-terminal

RNA

  1. XR_001784749.3 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_177136.3: Suppressed sequence

    Description
    NM_177136.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein, and the 3' end appears to be intronic.
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous