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ARHGEF1 Rho guanine nucleotide exchange factor 1 [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 722198, updated on 5-Mar-2024

Summary

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Official Symbol
ARHGEF1provided by VGNC
Official Full Name
Rho guanine nucleotide exchange factor 1provided by VGNC
Primary source
VGNC:VGNC:70012
See related
Ensembl:ENSMMUG00000022305
Gene type
protein coding
RefSeq status
MODEL
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 19
Exon count:
32
Annotation release Status Assembly Chr Location
103 current Mmul_10 (GCF_003339765.1) 19 NC_041772.1 (41026205..41051916)
102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 19 NC_027911.1 (37645826..37671539)

Chromosome 19 - NC_041772.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S19 Neighboring gene CD79a molecule Neighboring gene ETS repressor factor like Neighboring gene Rab acceptor 1 Neighboring gene ATPase Na+/K+ transporting subunit alpha 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables G protein-coupled receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
rho guanine nucleotide exchange factor 1
Names
Rho guanine nucleotide exchange factor (GEF) 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

  1. NC_041772.1 Reference Mmul_10 Primary Assembly

    Range
    41026205..41051916
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_028838865.1 → XP_028694698.1  rho guanine nucleotide exchange factor 1 isoform X1

    UniProtKB/TrEMBL
    A0A1D5QDZ8, A0A1D5QGD0
    Related
    ENSMMUP00000047100.1, ENSMMUT00000066536.2
    Conserved Domains (4) summary
    cd08755
    Location:52 → 244
    RGS_p115RhoGEF; Regulator of G protein signaling (RGS) domain found in the Rho guanine nucleotide exchange factor (GEF), p115 RhoGEF
    smart00325
    Location:478 → 662
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    PHA03307
    Location:291 → 472
    PHA03307; transcriptional regulator ICP4; Provisional
    cd14679
    Location:696 → 820
    PH_p115RhoGEF; Rho guanine nucleotide exchange factor Pleckstrin homology domain

  2. XM_015124061.2 → XP_014979547.1  rho guanine nucleotide exchange factor 1 isoform X2

    UniProtKB/TrEMBL
    A0A1D5QDZ8, A0A1D5QGD0, A0A5F8A6M7
    Related
    ENSMMUP00000072569.1, ENSMMUT00000101283.1
    Conserved Domains (4) summary
    pfam05887
    Location:315 → 404
    Trypan_PARP; Procyclic acidic repetitive protein (PARP)
    cd08755
    Location:52 → 244
    RGS_p115RhoGEF; Regulator of G protein signaling (RGS) domain found in the Rho guanine nucleotide exchange factor (GEF), p115 RhoGEF
    smart00325
    Location:420 → 604
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd14679
    Location:638 → 762
    PH_p115RhoGEF; Rho guanine nucleotide exchange factor Pleckstrin homology domain

  3. XM_015124063.2 → XP_014979549.1  rho guanine nucleotide exchange factor 1 isoform X2

    UniProtKB/TrEMBL
    A0A1D5QDZ8, A0A1D5QGD0, A0A5F8A6M7
    Conserved Domains (4) summary
    pfam05887
    Location:315 → 404
    Trypan_PARP; Procyclic acidic repetitive protein (PARP)
    cd08755
    Location:52 → 244
    RGS_p115RhoGEF; Regulator of G protein signaling (RGS) domain found in the Rho guanine nucleotide exchange factor (GEF), p115 RhoGEF
    smart00325
    Location:420 → 604
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd14679
    Location:638 → 762
    PH_p115RhoGEF; Rho guanine nucleotide exchange factor Pleckstrin homology domain
Nucleotide Protein
Heading Accession and Version

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