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Mms19 MMS19 cytosolic iron-sulfur assembly component [ Mus musculus (house mouse) ]

Gene ID: 72199, updated on 5-Mar-2024

Summary

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Official Symbol
Mms19provided by MGI
Official Full Name
MMS19 cytosolic iron-sulfur assembly componentprovided by MGI
Primary source
MGI:MGI:1919449
See related
Ensembl:ENSMUSG00000025159 AllianceGenome:MGI:1919449
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mms19l; 2410001K24Rik; 2610042O15Rik
Summary
Enables enzyme binding activity. Predicted to be involved in several processes, including iron-sulfur cluster assembly; positive regulation of nucleobase-containing compound metabolic process; and protein maturation by iron-sulfur cluster transfer. Predicted to be located in cytosol; nucleoplasm; and spindle. Predicted to be part of CIA complex and MMXD complex. Is expressed in several structures, including apical ectodermal ridge; liver; nervous system; neural retina; and trunk somite. Orthologous to human MMS19 (MMS19 homolog, cytosolic iron-sulfur assembly component). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 24.9), ovary adult (RPKM 20.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
19 C3; 19 35.49 cM
Exon count:
32
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (41932146..41969603, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (41943707..41981164, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7659 Neighboring gene phosphoglycerate mutase 1 Neighboring gene STARR-positive B cell enhancer ABC_E3252 Neighboring gene exosome component 1 Neighboring gene zinc finger, DHHC domain containing 16 Neighboring gene STARR-positive B cell enhancer ABC_E1524 Neighboring gene predicted gene, 23113 Neighboring gene ubiquitin domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_46168 Neighboring gene STARR-seq mESC enhancer starr_46171 Neighboring gene ankyrin repeat domain 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mms19 protein functions in nucleotide excision repair by sustaining an adequate cellular concentration of the TFIIH component Rad3. Kou H, et al. Proc Natl Acad Sci U S A, 2008 Oct 14. PMID 18836076, Free PMC Article
  2. Cloning the human and mouse MMS19 genes and functional complementation of a yeast mms19 deletion mutant. Queimado L, et al. Nucleic Acids Res, 2001 May 1. PMID 11328871, Free PMC Article
  3. The mammalian proteins MMS19, MIP18, and ANT2 are involved in cytoplasmic iron-sulfur cluster protein assembly. van Wietmarschen N, et al. J Biol Chem, 2012 Dec 21. PMID 23150669, Free PMC Article
  4. RTEL1 is a replisome-associated helicase that promotes telomere and genome-wide replication. Vannier JB, et al. Science, 2013 Oct 11. PMID 24115439
  5. MMS19 links cytoplasmic iron-sulfur cluster assembly to DNA metabolism. Gari K, et al. Science, 2012 Jul 13. PMID 22678361

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The mammalian proteins MMS19, MIP18, and ANT2 are involved in cytoplasmic iron-sulfur cluster protein assembly.
    Title: The mammalian proteins MMS19, MIP18, and ANT2 are involved in cytoplasmic iron-sulfur cluster protein assembly.
  2. in the absence of MMS19, a failure to transfer Fe-S clusters to target proteins is associated with Fe-S protein instability and preimplantation death of mice in which Mms19 has been knocked out; propose that MMS19 functions as a platform to facilitate Fe-S cluster transfer to proteins critical for DNA replication and repair
    Title: MMS19 links cytoplasmic iron-sulfur cluster assembly to DNA metabolism.
  3. Mms19 has distinct and separable functions in nucleotide excision repair and cell growth
    Title: Mms19 protein functions in nucleotide excision repair by sustaining an adequate cellular concentration of the TFIIH component Rad3.
  4. Cloning of the mouse MMS19 genes and functional complementation in Saccharomyces cerevisiae
    Title: Cloning the human and mouse MMS19 genes and functional complementation of a yeast mms19 deletion mutant.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables enzyme binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables nuclear estrogen receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within chromosome segregation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein maturation by iron-sulfur cluster transfer IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein maturation by iron-sulfur cluster transfer ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of CIA complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of CIA complex ISO
Inferred from Sequence Orthology
more info
  
part_of MMXD complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of MMXD complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in spindle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
MMS19 nucleotide excision repair protein homolog
Names
MET18 homolog
MMS19 (MET18 S. cerevisiae)
MMS19-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001373946.1 → NP_001360875.1  MMS19 nucleotide excision repair protein homolog isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC140193
    UniProtKB/TrEMBL
    F7C9N6
    Related
    ENSMUSP00000026168.3, ENSMUST00000026168.9
    Conserved Domains (2) summary
    pfam12460
    Location:527 → 962
    MMS19_C; RNAPII transcription regulator C-terminal
    pfam14500
    Location:54 → 312
    MMS19_N; Dos2-interacting transcription regulator of RNA-Pol-II

  2. NM_028152.3 → NP_082428.1  MMS19 nucleotide excision repair protein homolog isoform 1

    See identical proteins and their annotated locations for NP_082428.1

    Status: VALIDATED

    Source sequence(s)
    AC140193
    Consensus CDS
    CCDS29818.1
    UniProtKB/Swiss-Prot
    F8WHX3, Q925N8, Q9CWX3, Q9D071
    UniProtKB/TrEMBL
    F7C9N6
    Related
    ENSMUSP00000130900.2, ENSMUST00000171561.8
    Conserved Domains (2) summary
    pfam12460
    Location:528 → 963
    MMS19_C; RNAPII transcription regulator C-terminal
    pfam14500
    Location:54 → 312
    MMS19_N; Dos2-interacting transcription regulator of RNA-Pol-II

RNA

  1. NR_164197.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC140193
    Related
    ENSMUST00000163398.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    41932146..41969603 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011247350.3 → XP_011245652.1  MMS19 nucleotide excision repair protein homolog isoform X2

    UniProtKB/TrEMBL
    F7C9N6
    Conserved Domains (2) summary
    pfam12460
    Location:374 → 809
    MMS19_C; RNAPII transcription regulator C-terminal
    pfam14500
    Location:26 → 158
    MMS19_N; Dos2-interacting transcription regulator of RNA-Pol-II

  2. XM_030251078.2 → XP_030106938.1  MMS19 nucleotide excision repair protein homolog isoform X5

    Conserved Domains (1) summary
    pfam12460
    Location:163 → 598
    MMS19_C; RNAPII transcription regulator C-terminal

  3. XM_030251082.2 → XP_030106942.1  MMS19 nucleotide excision repair protein homolog isoform X6

    Conserved Domains (1) summary
    pfam12460
    Location:162 → 597
    MMS19_C; RNAPII transcription regulator C-terminal

  4. XM_030251081.2 → XP_030106941.1  MMS19 nucleotide excision repair protein homolog isoform X5

    Conserved Domains (1) summary
    pfam12460
    Location:163 → 598
    MMS19_C; RNAPII transcription regulator C-terminal

  5. XM_030251080.1 → XP_030106940.1  MMS19 nucleotide excision repair protein homolog isoform X5

    Conserved Domains (1) summary
    pfam12460
    Location:163 → 598
    MMS19_C; RNAPII transcription regulator C-terminal

  6. XM_030251079.1 → XP_030106939.1  MMS19 nucleotide excision repair protein homolog isoform X5

    Conserved Domains (1) summary
    pfam12460
    Location:163 → 598
    MMS19_C; RNAPII transcription regulator C-terminal

  7. XM_011247349.4 → XP_011245651.1  MMS19 nucleotide excision repair protein homolog isoform X1

    See identical proteins and their annotated locations for XP_011245651.1

    UniProtKB/TrEMBL
    F7C9N6
    Related
    ENSMUST00000171755.8
    Conserved Domains (2) summary
    pfam12460
    Location:528 → 886
    MMS19_C; RNAPII transcription regulator C-terminal
    pfam14500
    Location:54 → 312
    MMS19_N; Dos2-interacting transcription regulator of RNA-Pol-II

  8. XM_011247348.4 → XP_011245650.1  MMS19 nucleotide excision repair protein homolog isoform X1

    See identical proteins and their annotated locations for XP_011245650.1

    UniProtKB/TrEMBL
    F7C9N6
    Conserved Domains (2) summary
    pfam12460
    Location:528 → 886
    MMS19_C; RNAPII transcription regulator C-terminal
    pfam14500
    Location:54 → 312
    MMS19_N; Dos2-interacting transcription regulator of RNA-Pol-II

  9. XM_017318292.3 → XP_017173781.1  MMS19 nucleotide excision repair protein homolog isoform X4

    Conserved Domains (2) summary
    pfam12460
    Location:527 → 804
    MMS19_C; RNAPII transcription regulator C-terminal
    pfam14500
    Location:54 → 312
    MMS19_N; Dos2-interacting transcription regulator of RNA-Pol-II

  10. XM_011247351.4 → XP_011245653.1  MMS19 nucleotide excision repair protein homolog isoform X3

    Conserved Domains (2) summary
    pfam12460
    Location:528 → 805
    MMS19_C; RNAPII transcription regulator C-terminal
    pfam14500
    Location:54 → 312
    MMS19_N; Dos2-interacting transcription regulator of RNA-Pol-II

RNA

  1. XR_001782617.3 RNA Sequence

  2. XR_001782619.3 RNA Sequence

  3. XR_001782618.3 RNA Sequence

    Related
    ENSMUST00000164776.8
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D071.1 GenPept UniProtKB/Swiss-Prot:Q9D071

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