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Zbtb46 zinc finger and BTB domain containing 46 [ Mus musculus (house mouse) ]

Gene ID: 72147, updated on 23-Apr-2024

Summary

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Official Symbol
Zbtb46provided by MGI
Official Full Name
zinc finger and BTB domain containing 46provided by MGI
Primary source
MGI:MGI:1919397
See related
Ensembl:ENSMUSG00000027583 AllianceGenome:MGI:1919397
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
BZEL; Btbd4; 2610019F01Rik; 4933406L05Rik
Summary
Predicted to enable RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within regulation of leukocyte differentiation. Predicted to be active in nucleus. Is expressed in several structures, including brown fat; central nervous system; gonad; renal vasculature; and spleen. Orthologous to human ZBTB46 (zinc finger and BTB domain containing 46). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cerebellum adult (RPKM 5.1), lung adult (RPKM 4.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 H4; 2 103.63 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (181012105..181134776, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (181371009..181493262, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10172 Neighboring gene STARR-seq mESC enhancer starr_06749 Neighboring gene STARR-seq mESC enhancer starr_06750 Neighboring gene STARR-seq mESC enhancer starr_06751 Neighboring gene regulator of telomere elongation helicase 1 Neighboring gene STARR-positive B cell enhancer ABC_E4532 Neighboring gene ADP-ribosylation factor related protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E11178 Neighboring gene zinc finger, CCCH-type with G patch domain Neighboring gene Slc2a4 regulator, pseudogene Neighboring gene Lck interacting transmembrane adaptor 1 Neighboring gene predicted gene, 22708 Neighboring gene STARR-positive B cell enhancer mm9_chr2:181218272-181218572 Neighboring gene STARR-seq mESC enhancer starr_06754 Neighboring gene STARR-positive B cell enhancer ABC_E274 Neighboring gene abhydrolase domain containing 16B Neighboring gene tumor protein D52-like 2 Neighboring gene predicted gene, 25184

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. ZBTB46(+) ILC3s promote intestinal health. Hindson J. Nat Rev Gastroenterol Hepatol, 2022 Sep. PMID 35915158
  2. ZBTB46 defines and regulates ILC3s that protect the intestine. Zhou W, et al. Nature, 2022 Sep. PMID 35831503, Free PMC Article
  3. Dendritic Cell Maturation Defines Immunological Responsiveness of Tumors to Radiation Therapy. Blair TC, et al. J Immunol, 2020 Jun 15. PMID 32341058, Free PMC Article
  4. Tumor Dendritic Cells (DCs) Derived from Precursors of Conventional DCs Are Dispensable for Intratumor CTL Responses. Diao J, et al. J Immunol, 2018 Aug 15. PMID 29997124, Free PMC Article
  5. Long-term sustainable dendritic cell-specific depletion murine model for periodontitis research. Finger Stadler A, et al. J Immunol Methods, 2017 Oct. PMID 28645528

See all (118) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ZBTB46 defines and regulates ILC3s that protect the intestine.
    Title: ZBTB46 defines and regulates ILC3s that protect the intestine.
  2. ZBTB46(+) ILC3s promote intestinal health.
    Title: ZBTB46(+) ILC3s promote intestinal health.
  3. We studied the role of ZBTB46 in endothelial cells (ECs), hypothesizing that it inhibits EC proliferation. Using a model of disturbed flow, we found that ZBTB46 is expressed in arterial ECs in vivo, and is downregulated by disturbed flow.
    Title: ZBTB46 is a shear-sensitive transcription factor inhibiting endothelial cell proliferation via gene expression regulation of cell cycle proteins.
  4. Zbtb46 is a repressor of a transcriptional network that is extinguished upon immune stimulation by TLR ligands. This network is in part responsible for maintaining dendritic cells quiescence in the steady state.
    Title: Zinc finger transcription factor zDC is a negative regulator required to prevent activation of classical dendritic cells in the steady state.
  5. expression of the Btbd4 defines the classical dendritic cell lineage
    Title: Expression of the zinc finger transcription factor zDC (Zbtb46, Btbd4) defines the classical dendritic cell lineage.
  6. Zbtb46 may help enforce dendritic cell identity by restricting responsiveness to non-dendritic cells growth factors and may serve as a useful marker to identify rare dendritic cell progenitors
    Title: Zbtb46 expression distinguishes classical dendritic cells and their committed progenitors from other immune lineages.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (9)  1 citation
  • Endonuclease-mediated (6) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription cis-regulatory region binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of dendritic cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of granulocyte differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of macrophage differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of dendritic cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of granulocyte differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of leukocyte activation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of macrophage differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of monocyte differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of plasmacytoid dendritic cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of dendritic cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger and BTB domain-containing protein 46
Names
BTB (POZ) domain containing 4
BTB-ZF protein expressed in effector lymphocytes
BTB/POZ domain-containing protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027656.2 → NP_081932.1  zinc finger and BTB domain-containing protein 46 isoform 1

    See identical proteins and their annotated locations for NP_081932.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK011461, AK016700, AL928965
    Consensus CDS
    CCDS50854.1
    UniProtKB/Swiss-Prot
    A2AUD2, Q3U2R2, Q8BID6, Q9D0G6, Q9D492
    Related
    ENSMUSP00000137014.2, ENSMUST00000180222.8
    Conserved Domains (4) summary
    sd00017
    Location:420 → 440
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18230
    Location:10 → 134
    BTB_POZ_ZBTB46; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46)
    pfam13465
    Location:433 → 457
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:418 → 442
    zf-H2C2_5; C2H2-type zinc-finger domain

  2. NM_028125.3 → NP_082401.1  zinc finger and BTB domain-containing protein 46 isoform 2

    See identical proteins and their annotated locations for NP_082401.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate 3' terminus, compared to variant 1, that results in a protein (isoform 2) with a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK011461, AL929094
    Consensus CDS
    CCDS17212.1
    UniProtKB/Swiss-Prot
    Q8BID6
    Related
    ENSMUSP00000084672.4, ENSMUST00000087409.10
    Conserved Domains (1) summary
    cd18230
    Location:10 → 134
    BTB_POZ_ZBTB46; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    181012105..181134776 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006500714.5 → XP_006500777.1  zinc finger and BTB domain-containing protein 46 isoform X2

    Conserved Domains (4) summary
    sd00017
    Location:420 → 440
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18230
    Location:10 → 134
    BTB_POZ_ZBTB46; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46)
    pfam13465
    Location:433 → 457
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:418 → 442
    zf-H2C2_5; C2H2-type zinc-finger domain

  2. XM_006500713.4 → XP_006500776.1  zinc finger and BTB domain-containing protein 46 isoform X1

    See identical proteins and their annotated locations for XP_006500776.1

    UniProtKB/Swiss-Prot
    A2AUD2, Q3U2R2, Q8BID6, Q9D0G6, Q9D492
    Conserved Domains (4) summary
    sd00017
    Location:420 → 440
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18230
    Location:10 → 134
    BTB_POZ_ZBTB46; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46)
    pfam13465
    Location:433 → 457
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:418 → 442
    zf-H2C2_5; C2H2-type zinc-finger domain

  3. XM_006500712.5 → XP_006500775.1  zinc finger and BTB domain-containing protein 46 isoform X1

    See identical proteins and their annotated locations for XP_006500775.1

    UniProtKB/Swiss-Prot
    A2AUD2, Q3U2R2, Q8BID6, Q9D0G6, Q9D492
    Related
    ENSMUSP00000029106.7, ENSMUST00000029106.13
    Conserved Domains (4) summary
    sd00017
    Location:420 → 440
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18230
    Location:10 → 134
    BTB_POZ_ZBTB46; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46)
    pfam13465
    Location:433 → 457
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:418 → 442
    zf-H2C2_5; C2H2-type zinc-finger domain

  4. XM_006500715.5 → XP_006500778.1  zinc finger and BTB domain-containing protein 46 isoform X3

    Conserved Domains (1) summary
    cd18230
    Location:10 → 134
    BTB_POZ_ZBTB46; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46)

RNA

  1. XR_867136.4 RNA Sequence

  2. XR_001783183.3 RNA Sequence

  3. XR_375402.5 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BID6.2 GenPept UniProtKB/Swiss-Prot:Q8BID6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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