U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Tmem68 transmembrane protein 68 [ Mus musculus (house mouse) ]

Gene ID: 72098, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Tmem68provided by MGI
Official Full Name
transmembrane protein 68provided by MGI
Primary source
MGI:MGI:1919348
See related
Ensembl:ENSMUSG00000028232 AllianceGenome:MGI:1919348
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Diesl; MGAT/DGAT; 2010300G19Rik
Summary
Predicted to enable acyltransferase activity. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in genitourinary system. Orthologous to human TMEM68 (transmembrane protein 68). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E18 (RPKM 9.6), whole brain E14.5 (RPKM 7.5) and 20 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Tmem68 in Genome Data Viewer
Location:
4 A1; 4 1.98 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (3549041..3574853, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (3549041..3574867, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene 11787 Neighboring gene STARR-seq mESC enhancer starr_09413 Neighboring gene microRNA 3471-2 Neighboring gene trimethylguanosine synthase 1 Neighboring gene STARR-positive B cell enhancer ABC_E4609 Neighboring gene STARR-positive B cell enhancer mm9_chr4:3574269-3574569 Neighboring gene STARR-positive B cell enhancer ABC_E6150 Neighboring gene RIKEN cDNA 2210414B05 gene Neighboring gene STARR-seq mESC enhancer starr_09415 Neighboring gene predicted gene, 42250

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The sperm-associated antigen 6 interactome and its role in spermatogenesis. Liu Y, et al. Reproduction, 2019 Aug. PMID 31146259, Free PMC Article
  2. Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives. Tamplin OJ, et al. BMC Genomics, 2008 Oct 30. PMID 18973680, Free PMC Article
  3. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
  4. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
  5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Identification of an alternative triglyceride biosynthesis pathway.
    Title: Identification of an alternative triglyceride biosynthesis pathway.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (1) 

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 2-acylglycerol O-acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables diacylglycerol O-acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables phospholipid:diacylglycerol acyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in triglyceride biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
DGAT1/2-independent enzyme synthesizing storage lipids
Names
2-acylglycerol/1,2-diacylglycerol O-acyltransferase
monoacylglycerol/Diacylglycerol O-acyltransferase
NP_082373.1
XP_006538332.1
XP_030109665.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028097.4 → NP_082373.1  DGAT1/2-independent enzyme synthesizing storage lipids

    See identical proteins and their annotated locations for NP_082373.1

    Status: VALIDATED

    Source sequence(s)
    AK048210, AK084881, AL732617
    Consensus CDS
    CCDS17937.1
    UniProtKB/Swiss-Prot
    Q3UGT4, Q8BTV3, Q9D850
    Related
    ENSMUSP00000029891.6, ENSMUST00000029891.12
    Conserved Domains (2) summary
    cd07987
    Location:103 → 309
    LPLAT_MGAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like
    COG0204
    Location:58 → 303
    PlsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]

RNA

  1. NR_149728.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AK048210, AK084881, AK162563, AL732617
    Related
    ENSMUST00000154922.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    3549041..3574853 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006538269.5 → XP_006538332.1  DGAT1/2-independent enzyme synthesizing storage lipids isoform X1

    See identical proteins and their annotated locations for XP_006538332.1

    Conserved Domains (1) summary
    cd07987
    Location:1 → 195
    LPLAT_MGAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like

  2. XM_030253805.2 → XP_030109665.1  DGAT1/2-independent enzyme synthesizing storage lipids isoform X1

    Conserved Domains (1) summary
    cd07987
    Location:1 → 195
    LPLAT_MGAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like

RNA

  1. XR_001784202.3 RNA Sequence

  2. XR_004941966.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D850.1 GenPept UniProtKB/Swiss-Prot:Q9D850

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous