U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Gcnt3 glucosaminyl (N-acetyl) transferase 3, mucin type [ Mus musculus (house mouse) ]

Gene ID: 72077, updated on 21-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Gcnt3provided by MGI
Official Full Name
glucosaminyl (N-acetyl) transferase 3, mucin typeprovided by MGI
Primary source
MGI:MGI:1919327
See related
Ensembl:ENSMUSG00000032226 AllianceGenome:MGI:1919327
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2010013H22Rik; 2210021I22Rik; 2210401J11Rik
Summary
Enables acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity. Acts upstream of or within intestinal absorption; kidney morphogenesis; and tissue morphogenesis. Predicted to be located in Golgi apparatus and membrane. Predicted to be integral component of membrane. Orthologous to human GCNT3 (glucosaminyl (N-acetyl) transferase 3, mucin type). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in colon adult (RPKM 13.8), stomach adult (RPKM 9.8) and 7 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
9 D; 9 39.2 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (69938777..69947172, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (70031495..70039890, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6762 Neighboring gene BCL2/adenovirus E1B interacting protein 2 Neighboring gene STARR-seq mESC enhancer starr_24528 Neighboring gene general transcription factor II A, 2 Neighboring gene STARR-seq mESC enhancer starr_24529 Neighboring gene STARR-seq mESC enhancer starr_24532 Neighboring gene STARR-seq mESC enhancer starr_24534 Neighboring gene predicted gene, 39369 Neighboring gene family with sequence similarity 81, member A

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Mucin biosynthesis: molecular cloning and expression of mouse mucus-type core 2 beta1,6 N-acetylglucosaminyltransferase. Hashimoto M, et al. Glycobiology, 2007 Sep. PMID 17591617
  2. Small-Molecule Inhibition of GCNT3 Disrupts Mucin Biosynthesis and Malignant Cellular Behaviors in Pancreatic Cancer. Rao CV, et al. Cancer Res, 2016 Apr 1. PMID 26880801
  3. High-sensitivity O-glycomic analysis of mice deficient in core 2 {beta}1,6-N-acetylglucosaminyltransferases. Ismail MN, et al. Glycobiology, 2011 Jan. PMID 20855471, Free PMC Article
  4. Sialoadhesin ligand expression identifies a subset of CD4+Foxp3- T cells with a distinct activation and glycosylation profile. Kidder D, et al. J Immunol, 2013 Mar 15. PMID 23408841, Free PMC Article
  5. Requirement for core 2 O-glycans for optimal resistance to helminth infection. Mullaly SC, et al. PLoS One, 2013. PMID 23555902, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables acetylgalactosaminyl-O-glycosyl-seryl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables acetylgalactosaminyl-O-glycosyl-threonyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables acetylglucosaminyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acetylglucosaminyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within immunoglobulin production in mucosal tissue IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within intestinal absorption IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within kidney morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within protein O-linked glycosylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within tissue morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3
Names
C2GnT-M
C2GnT-mucin type
core 2 beta-1,6-N-acetylglucosaminyltransferase II
mucus-type core 2 beta-1,6-N-acetylglucosaminyltransferase
NP_082363.2
XP_006511526.1
XP_011241117.1
XP_011241118.1
XP_030100480.1
XP_030100481.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028087.2 → NP_082363.2  beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3

    See identical proteins and their annotated locations for NP_082363.2

    Status: PROVISIONAL

    Source sequence(s)
    EF202835
    Consensus CDS
    CCDS40678.1
    UniProtKB/Swiss-Prot
    A2TIK7, Q5JCT0, Q8VCX9, Q9D8A3
    Related
    ENSMUSP00000034751.6, ENSMUST00000034751.6
    Conserved Domains (1) summary
    pfam02485
    Location:133 → 400
    Branch; Core-2/I-Branching enzyme

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    69938777..69947172 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011242816.3 → XP_011241118.1  beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 isoform X1

    See identical proteins and their annotated locations for XP_011241118.1

    UniProtKB/Swiss-Prot
    A2TIK7, Q5JCT0, Q8VCX9, Q9D8A3
    Conserved Domains (1) summary
    pfam02485
    Location:133 → 400
    Branch; Core-2/I-Branching enzyme

  2. XM_030244620.1 → XP_030100480.1  beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 isoform X1

    UniProtKB/Swiss-Prot
    A2TIK7, Q5JCT0, Q8VCX9, Q9D8A3
    Conserved Domains (1) summary
    pfam02485
    Location:133 → 400
    Branch; Core-2/I-Branching enzyme

  3. XM_011242815.3 → XP_011241117.1  beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 isoform X1

    See identical proteins and their annotated locations for XP_011241117.1

    UniProtKB/Swiss-Prot
    A2TIK7, Q5JCT0, Q8VCX9, Q9D8A3
    Conserved Domains (1) summary
    pfam02485
    Location:133 → 400
    Branch; Core-2/I-Branching enzyme

  4. XM_006511463.4 → XP_006511526.1  beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 isoform X1

    See identical proteins and their annotated locations for XP_006511526.1

    UniProtKB/Swiss-Prot
    A2TIK7, Q5JCT0, Q8VCX9, Q9D8A3
    Conserved Domains (1) summary
    pfam02485
    Location:133 → 400
    Branch; Core-2/I-Branching enzyme

  5. XM_030244621.1 → XP_030100481.1  beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 isoform X1

    UniProtKB/Swiss-Prot
    A2TIK7, Q5JCT0, Q8VCX9, Q9D8A3
    Conserved Domains (1) summary
    pfam02485
    Location:133 → 400
    Branch; Core-2/I-Branching enzyme
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5JCT0.2 GenPept UniProtKB/Swiss-Prot:Q5JCT0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous