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Trmu tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase [ Mus musculus (house mouse) ]

Gene ID: 72026, updated on 21-Apr-2024

Summary

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Official Symbol
Trmuprovided by MGI
Official Full Name
tRNA 5-methylaminomethyl-2-thiouridylate methyltransferaseprovided by MGI
Primary source
MGI:MGI:1919276
See related
Ensembl:ENSMUSG00000022386 AllianceGenome:MGI:1919276
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mtu1; Trmt1; 1110005N20Rik; 1600025P05Rik
Summary
Predicted to enable ATP binding activity; sulfurtransferase activity; and tRNA binding activity. Predicted to be involved in tRNA wobble position uridine thiolation. Located in mitochondrion. Used to study liver disease. Human ortholog(s) of this gene implicated in aminoglycoside-induced deafness; infantile liver failure syndrome; and transient infantile liver failure. Orthologous to human TRMU (tRNA mitochondrial 2-thiouridylase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E14 (RPKM 11.1), CNS E18 (RPKM 10.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
15 E2; 15 40.42 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (85763505..85781595)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (85879309..85897394)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene tetratricopeptide repeat domain 38 Neighboring gene STARR-seq mESC enhancer starr_39401 Neighboring gene STARR-positive B cell enhancer ABC_E4144 Neighboring gene G two S phase expressed protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E10874 Neighboring gene cadherin, EGF LAG seven-pass G-type receptor 1 Neighboring gene STARR-seq mESC enhancer starr_39409 Neighboring gene predicted gene, 34764

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mtu1 defects are correlated with reduced osteogenic differentiation. He Q, et al. Cell Death Dis, 2021 Jan 11. PMID 33431792, Free PMC Article
  2. Identification and characterization of mouse TRMU gene encoding the mitochondrial 5-methylaminomethyl-2-thiouridylate-methyltransferase. Yan Q, et al. Biochim Biophys Acta, 2004 Jan 20. PMID 14746906
  3. Mtu1-Mediated Thiouridine Formation of Mitochondrial tRNAs Is Required for Mitochondrial Translation and Is Involved in Reversible Infantile Liver Injury. Wu Y, et al. PLoS Genet, 2016 Sep. PMID 27689697, Free PMC Article
  4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. plays a role in mitochondrial tRNA modification pathway and the pathogenesis of mitochondrial disorders
    Title: Identification and characterization of mouse TRMU gene encoding the mitochondrial 5-methylaminomethyl-2-thiouridylate-methyltransferase.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables sulfurtransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables tRNA binding IEA
Inferred from Electronic Annotation
more info
  
enables tRNA-5-taurinomethyluridine 2-sulfurtransferase IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within tRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA wobble position uridine thiolation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
mitochondrial tRNA-specific 2-thiouridylase 1
Names
tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase 1
NP_082339.1
XP_006521485.1
XP_006521486.1
XP_006521487.1
XP_006521488.1
XP_036015492.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028063.2 → NP_082339.1  mitochondrial tRNA-specific 2-thiouridylase 1

    See identical proteins and their annotated locations for NP_082339.1

    Status: VALIDATED

    Source sequence(s)
    AC139513
    Consensus CDS
    CCDS27726.1
    UniProtKB/Swiss-Prot
    Q9DAT5
    Related
    ENSMUSP00000023019.6, ENSMUST00000023019.12
    Conserved Domains (2) summary
    cd01998
    Location:6 → 383
    tRNA_Me_trans; tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs. ...
    pfam03054
    Location:5 → 383
    tRNA_Me_trans; tRNA methyl transferase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    85763505..85781595
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006521422.3 → XP_006521485.1  mitochondrial tRNA-specific 2-thiouridylase 1 isoform X1

    Conserved Domains (1) summary
    cd01998
    Location:6 → 258
    tRNA_Me_trans; tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs. ...

  2. XM_006521424.2 → XP_006521487.1  mitochondrial tRNA-specific 2-thiouridylase 1 isoform X2

    Conserved Domains (1) summary
    pfam03054
    Location:5 → 269
    tRNA_Me_trans; tRNA methyl transferase

  3. XM_006521425.2 → XP_006521488.1  mitochondrial tRNA-specific 2-thiouridylase 1 isoform X4

    Conserved Domains (1) summary
    pfam03054
    Location:39 → 243
    tRNA_Me_trans; tRNA methyl transferase

  4. XM_006521423.5 → XP_006521486.1  mitochondrial tRNA-specific 2-thiouridylase 1 isoform X3

    Conserved Domains (1) summary
    pfam03054
    Location:71 → 275
    tRNA_Me_trans; tRNA methyl transferase

  5. XM_036159599.1 → XP_036015492.1  mitochondrial tRNA-specific 2-thiouridylase 1 isoform X5

    Conserved Domains (1) summary
    pfam03054
    Location:71 → 150
    tRNA_Me_trans; tRNA methyl transferase

RNA

  1. XR_001781567.2 RNA Sequence

  2. XR_384047.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DAT5.1 GenPept UniProtKB/Swiss-Prot:Q9DAT5

Gene LinkOut

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