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Rpap3 RNA polymerase II associated protein 3 [ Mus musculus (house mouse) ]

Gene ID: 71919, updated on 5-Mar-2024

Summary

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Official Symbol
Rpap3provided by MGI
Official Full Name
RNA polymerase II associated protein 3provided by MGI
Primary source
MGI:MGI:1277218
See related
Ensembl:ENSMUSG00000022466 AllianceGenome:MGI:1277218
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D15Ertd682e; 2310042P20Rik
Summary
Predicted to be located in cytosol. Predicted to be part of R2TP complex. Orthologous to human RPAP3 (RNA polymerase II associated protein 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 11.3), CNS E18 (RPKM 8.9) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Rpap3 in Genome Data Viewer
Location:
15 F1; 15 53.54 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (97572978..97603746, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (97675097..97705822, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_39629 Neighboring gene predicted gene, 41393 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:97289192-97289405 Neighboring gene STARR-seq mESC enhancer starr_39631 Neighboring gene STARR-seq mESC enhancer starr_39632 Neighboring gene STARR-seq mESC enhancer starr_39633 Neighboring gene STARR-seq mESC enhancer starr_39634 Neighboring gene predicted gene, 41394 Neighboring gene STARR-positive B cell enhancer ABC_E10876 Neighboring gene STARR-positive B cell enhancer ABC_E7415 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:97551732-97551973 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:97561501-97561858 Neighboring gene STARR-positive B cell enhancer ABC_E5512 Neighboring gene STARR-positive B cell enhancer ABC_E2450 Neighboring gene endonuclease, polyU-specific Neighboring gene Rap guanine nucleotide exchange factor (GEF) 3 Neighboring gene predicted gene, 33531

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The HSP90/R2TP assembly chaperone promotes cell proliferation in the intestinal epithelium. Maurizy C, et al. Nat Commun, 2021 Aug 10. PMID 34376666, Free PMC Article
  2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  3. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
  4. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
  5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
part_of R2TP complex ISO
Inferred from Sequence Orthology
more info
  
part_of RPAP3/R2TP/prefoldin-like complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
part_of protein folding chaperone complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein folding chaperone complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
RNA polymerase II-associated protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028003.2 → NP_082279.1  RNA polymerase II-associated protein 3

    See identical proteins and their annotated locations for NP_082279.1

    Status: PROVISIONAL

    Source sequence(s)
    AK009765
    Consensus CDS
    CCDS27782.1
    UniProtKB/Swiss-Prot
    Q9D706
    Related
    ENSMUSP00000023104.6, ENSMUST00000023104.7
    Conserved Domains (4) summary
    PLN03088
    Location:137 → 257
    PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
    TIGR00990
    Location:112 → 385
    3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
    sd00006
    Location:134 → 162
    TPR; TPR repeat [structural motif]
    pfam13877
    Location:540 → 627
    RPAP3_C; Potential Monad-binding region of RPAP3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    97572978..97603746 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159597.1 → XP_036015490.1  RNA polymerase II-associated protein 3 isoform X1

    Conserved Domains (4) summary
    PLN03088
    Location:137 → 257
    PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
    TIGR00990
    Location:112 → 385
    3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
    sd00006
    Location:134 → 162
    TPR; TPR repeat [structural motif]
    pfam13877
    Location:540 → 616
    RPAP3_C; Potential Monad-binding region of RPAP3

  2. XM_011245735.2 → XP_011244037.1  RNA polymerase II-associated protein 3 isoform X2

    Conserved Domains (3) summary
    PLN03088
    Location:135 → 270
    PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
    sd00006
    Location:124 → 152
    TPR; TPR repeat [structural motif]
    pfam13877
    Location:380 → 467
    RPAP3_C; Potential Monad-binding region of RPAP3

  3. XM_036159598.1 → XP_036015491.1  RNA polymerase II-associated protein 3 isoform X3

    Conserved Domains (3) summary
    PLN03088
    Location:2 → 105
    PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
    sd00006
    Location:26 → 56
    TPR; TPR repeat [structural motif]
    pfam13877
    Location:215 → 302
    RPAP3_C; Potential Monad-binding region of RPAP3

  4. XM_030248782.2 → XP_030104642.1  RNA polymerase II-associated protein 3 isoform X3

    Conserved Domains (3) summary
    PLN03088
    Location:2 → 105
    PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
    sd00006
    Location:26 → 56
    TPR; TPR repeat [structural motif]
    pfam13877
    Location:215 → 302
    RPAP3_C; Potential Monad-binding region of RPAP3

  5. XM_030248783.1 → XP_030104643.1  RNA polymerase II-associated protein 3 isoform X3

    Conserved Domains (3) summary
    PLN03088
    Location:2 → 105
    PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
    sd00006
    Location:26 → 56
    TPR; TPR repeat [structural motif]
    pfam13877
    Location:215 → 302
    RPAP3_C; Potential Monad-binding region of RPAP3
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D706.1 GenPept UniProtKB/Swiss-Prot:Q9D706

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