Zswim2 zinc finger SWIM-type containing 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zswim2provided by MGI
Official Full Name: zinc finger SWIM-type containing 2provided by MGI
Primary source: MGI:MGI:1919111
See related: Ensembl:ENSMUSG00000034552 AllianceGenome:MGI:1919111
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MEX; 1700025P14Rik; 4933437F18Rik
Summary: Enables protein self-association and ubiquitin protein ligase activity. Involved in protein polyubiquitination. Acts upstream of or within positive regulation of extrinsic apoptotic signaling pathway via death domain receptors. Orthologous to human ZSWIM2 (zinc finger SWIM-type containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward testis adult (RPKM 15.6) See more
Orthologs: human all
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Genomic context

Location:: 2 D; 2 49.33 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (83745414..83771596, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (83915079..83941226, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MEX(identical to Zswim2) has homology to MEKK1 & is expressed uniquely in testis. MEX has 4 putative zinc-binding domains including an N-terminal SWIM (SWI2/SNF2 & MuDR) domain of unknown function & 2 RING fingers separated by ZZ zinc finger domain
Title: MEX is a testis-specific E3 ubiquitin ligase that promotes death receptor-induced apoptosis.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin-protein transferase activity	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of extrinsic apoptotic signaling pathway via death domain receptors	IDA Inferred from Direct Assay more info	PubMed
involved_in protein polyubiquitination	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase Zswim2

Names: MEKK1-related protein X; RING-type E3 ubiquitin transferase Zswim2; ZZ-type zinc finger-containing protein 2; zinc finger SWIM domain-containing protein 2; zinc finger, SWIM domain containing 2

NP_001405665.1

EC 2.3.2.27

NP_082240.1

EC 2.3.2.27

XP_036018470.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001418736.1 → NP_001405665.1 E3 ubiquitin-protein ligase Zswim2 isoform 2

Status: VALIDATED

Source sequence(s)

AL772256
NM_027964.3 → NP_082240.1 E3 ubiquitin-protein ligase Zswim2 isoform 1

See identical proteins and their annotated locations for NP_082240.1

Status: VALIDATED

Source sequence(s)

AL772256

Consensus CDS

CCDS16183.1

UniProtKB/Swiss-Prot

Q9D9X6

UniProtKB/TrEMBL

Q0VB10

Related

ENSMUSP00000044913.2, ENSMUST00000038223.8

Conserved Domains (3) summary

pfam04434
Location:54 → 86

SWIM; SWIM zinc finger

pfam13639
Location:343 → 386

zf-RING_2; Ring finger domain

cl00295
Location:233 → 271

ZZ; Zinc finger, ZZ type. Zinc finger present in dystrophin, CBP/p300 and many other proteins. The ZZ motif coordinates one or two zinc ions and most likely participates in ligand binding or molecular scaffolding. Many proteins containing ZZ motifs have ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

83745414..83771596 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036162577.1 → XP_036018470.1 E3 ubiquitin-protein ligase Zswim2 isoform X1

UniProtKB/TrEMBL

B2FDH1

Related

ENSMUSP00000119439.2, ENSMUST00000152829.2

Conserved Domains (4) summary

pfam04434
Location:54 → 86

SWIM; SWIM zinc finger

cd16494
Location:144 → 202

RING-CH-C4HC3_ZSWM2; RING-CH finger, H2 subclass (C4HC3-type), found in zinc finger SWIM domain-containing protein 2 (ZSWIM2) and similar proteins

cl00295
Location:233 → 271

ZZ; Zinc finger, ZZ type. Zinc finger present in dystrophin, CBP/p300 and many other proteins. The ZZ motif coordinates one or two zinc ions and most likely participates in ligand binding or molecular scaffolding. Many proteins containing ZZ motifs have ...

cl17238
Location:343 → 365

RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain