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Tasl TLR adaptor interacting with endolysosomal SLC15A4 [ Mus musculus (house mouse) ]

Gene ID: 71398, updated on 5-Mar-2024

Summary

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Official Symbol
Taslprovided by MGI
Official Full Name
TLR adaptor interacting with endolysosomal SLC15A4provided by MGI
Primary source
MGI:MGI:1918648
See related
Ensembl:ENSMUSG00000025058 AllianceGenome:MGI:1918648
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
5430427O19Rik
Summary
Predicted to be involved in positive regulation of innate immune response; positive regulation of toll-like receptor signaling pathway; and regulation of lysosomal lumen pH. Predicted to act upstream of or within innate immune response. Predicted to be located in endolysosome membrane. Orthologous to human TASL (TLR adaptor interacting with endolysosomal SLC15A4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
human all
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Genomic context

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Location:
X C1; X 39.39 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (84820445..84935105)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (85776968..85891499)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene TGF-beta activated kinase 1/MAP3K7 binding protein 3 Neighboring gene predicted gene, 39523 Neighboring gene STARR-seq mESC enhancer starr_47495 Neighboring gene STARR-seq mESC enhancer starr_47496 Neighboring gene glycerol kinase Neighboring gene STARR-positive B cell enhancer ABC_E8762 Neighboring gene replication protein A 14 kDa subunit pseudogene Neighboring gene mitochondrial import receptor subunit TOM20 homolog pseudogene Neighboring gene predicted gene 14762 Neighboring gene predicted gene, 54063 Neighboring gene STARR-seq mESC enhancer starr_47497 Neighboring gene spermatogenesis associated multipass transmembrane protein 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  2. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
  3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of innate immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of toll-like receptor 7 signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of toll-like receptor 8 signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of lysosomal lumen pH IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of lysosomal lumen pH ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of toll-like receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in endolysosome membrane ISO
Inferred from Sequence Orthology
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in lysosome IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
TLR adapter interacting with SLC15A4 on the lysosome
Names
protein CXorf21 homolog
uncharacterized protein CXorf21 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163539.1 → NP_001157011.1  TLR adapter interacting with SLC15A4 on the lysosome

    See identical proteins and their annotated locations for NP_001157011.1

    Status: VALIDATED

    Source sequence(s)
    AK017351, AK155591, AL672066, BY203970
    Consensus CDS
    CCDS53127.1
    UniProtKB/Swiss-Prot
    Q9D3J9
    UniProtKB/TrEMBL
    Q08EG0
    Related
    ENSMUSP00000109609.2, ENSMUST00000113976.2
    Conserved Domains (1) summary
    pfam15133
    Location:1 → 293
    DUF4569; Domain of unknown function (DUF4569)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    84820445..84935105
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011247682.3 → XP_011245984.1  TLR adapter interacting with SLC15A4 on the lysosome isoform X1

    See identical proteins and their annotated locations for XP_011245984.1

    UniProtKB/Swiss-Prot
    Q9D3J9
    UniProtKB/TrEMBL
    Q08EG0
    Conserved Domains (1) summary
    pfam15133
    Location:1 → 293
    DUF4569; Domain of unknown function (DUF4569)

  2. XM_017318620.3 → XP_017174109.1  TLR adapter interacting with SLC15A4 on the lysosome isoform X1

    UniProtKB/Swiss-Prot
    Q9D3J9
    UniProtKB/TrEMBL
    Q08EG0
    Conserved Domains (1) summary
    pfam15133
    Location:1 → 293
    DUF4569; Domain of unknown function (DUF4569)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D3J9.1 GenPept UniProtKB/Swiss-Prot:Q9D3J9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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