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Apobec4 apolipoprotein B mRNA editing enzyme catalytic polypeptide-like 4 [ Mus musculus (house mouse) ]

Gene ID: 71281, updated on 9-Mar-2024

Summary

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Official Symbol
Apobec4provided by MGI
Official Full Name
apolipoprotein B mRNA editing enzyme catalytic polypeptide-like 4provided by MGI
Primary source
MGI:MGI:1918531
See related
Ensembl:ENSMUSG00000055547 AllianceGenome:MGI:1918531
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4933431M11Rik
Summary
Predicted to enable hydrolase activity and metal ion binding activity. Predicted to act upstream of or within mRNA processing. Orthologous to human APOBEC4 (apolipoprotein B mRNA editing enzyme catalytic polypeptide like 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis adult (RPKM 23.3) See more
Orthologs
human all
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Genomic context

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Location:
1 G3; 1 65.01 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (152626302..152633295)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (152750551..152757544)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene ral guanine nucleotide dissociation stimulator,-like 1 Neighboring gene predicted gene, 51749 Neighboring gene STARR-seq mESC enhancer starr_02640 Neighboring gene STARR-seq mESC enhancer starr_02641 Neighboring gene ornithine decarboxylase, structural 1 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E5819 Neighboring gene STARR-positive B cell enhancer ABC_E2566 Neighboring gene STARR-positive B cell enhancer ABC_E2567 Neighboring gene actin related protein 2/3 complex, subunit 5 Neighboring gene STARR-positive B cell enhancer ABC_E1566 Neighboring gene STARR-positive B cell enhancer ABC_E4358 Neighboring gene STARR-seq mESC enhancer starr_02648 Neighboring gene neutrophil cytosolic factor 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. APOBEC4, a new member of the AID/APOBEC family of polynucleotide (deoxy)cytidine deaminases predicted by computational analysis. Rogozin IB, et al. Cell Cycle, 2005 Sep. PMID 16082223
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
  5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. APOBEC4 is expressed primarily in testis which suggests the possibility that it is an editing enzyme for mRNAs involved in spermatogenesis
    Title: APOBEC4, a new member of the AID/APOBEC family of polynucleotide (deoxy)cytidine deaminases predicted by computational analysis.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
putative C->U-editing enzyme APOBEC-4
Names
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative)
NP_001074666.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081197.1 → NP_001074666.1  putative C->U-editing enzyme APOBEC-4

    See identical proteins and their annotated locations for NP_001074666.1

    Status: PROVISIONAL

    Source sequence(s)
    AC123613
    Consensus CDS
    CCDS35738.1
    UniProtKB/Swiss-Prot
    Q497M3
    Related
    ENSMUSP00000069723.5, ENSMUST00000068875.5
    Conserved Domains (2) summary
    pfam08210
    Location:47 → 203
    APOBEC_N; APOBEC-like N-terminal domain
    cl21470
    Location:192 → 255
    Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    152626302..152633295
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q497M3.2 GenPept UniProtKB/Swiss-Prot:Q497M3

Gene LinkOut

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