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Uvssa UV stimulated scaffold protein A [ Mus musculus (house mouse) ]

Gene ID: 71101, updated on 5-Mar-2024

Summary

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Official Symbol
Uvssaprovided by MGI
Official Full Name
UV stimulated scaffold protein Aprovided by MGI
Primary source
MGI:MGI:1918351
See related
Ensembl:ENSMUSG00000037355 AllianceGenome:MGI:1918351
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Kiaa1530; mKIAA1530; 4933407H18Rik; D330017J19Rik
Summary
Predicted to enable RNA polymerase II complex binding activity. Predicted to be involved in protein ubiquitination; response to UV; and transcription-coupled nucleotide-excision repair. Predicted to act upstream of or within DNA repair. Predicted to be located in nucleoplasm. Predicted to be active in chromosome. Human ortholog(s) of this gene implicated in UV-sensitive syndrome. Orthologous to human UVSSA (UV stimulated scaffold protein A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 3.8), limb E14.5 (RPKM 3.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 B1; 5 17.6 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (33535868..33578243)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (33378523..33420899)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene 20465 Neighboring gene STARR-seq mESC enhancer starr_12818 Neighboring gene STARR-seq mESC enhancer starr_12819 Neighboring gene macrophage erythroblast attacher Neighboring gene STARR-positive B cell enhancer ABC_E4752 Neighboring gene STARR-positive B cell enhancer ABC_E11724 Neighboring gene NK1 homeobox 1 Neighboring gene STARR-positive B cell enhancer ABC_E10313 Neighboring gene STARR-seq mESC enhancer starr_12825 Neighboring gene STARR-seq mESC enhancer starr_12826 Neighboring gene STARR-positive B cell enhancer ABC_E6317 Neighboring gene family with sequence similarity 53, member A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
  2. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA polymerase II complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II complex binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in response to UV IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to UV ISO
Inferred from Sequence Orthology
more info
  
involved_in transcription-coupled nucleotide-excision repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transcription-coupled nucleotide-excision repair ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in chromosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in chromosome ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
UV-stimulated scaffold protein A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081101.2 → NP_001074570.1  UV-stimulated scaffold protein A

    See identical proteins and their annotated locations for NP_001074570.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC145072, AK016722, AK040506, BB590196, BM941364
    Consensus CDS
    CCDS39064.1
    UniProtKB/Swiss-Prot
    B2RQ84, B7ZN03, Q3U1A8, Q6P7V8, Q6ZPN7, Q9D479
    Related
    ENSMUSP00000085170.6, ENSMUST00000087864.12
    Conserved Domains (1) summary
    pfam09740
    Location:505 → 608
    DUF2043; Uncharacterized conserved protein (DUF2043)

  2. NM_027674.1 → NP_081950.1  UV-stimulated scaffold protein A

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC145072
    Consensus CDS
    CCDS39064.1
    UniProtKB/Swiss-Prot
    B2RQ84, B7ZN03, Q3U1A8, Q6P7V8, Q6ZPN7, Q9D479
    Related
    ENSMUSP00000144400.2, ENSMUST00000202816.2
    Conserved Domains (1) summary
    pfam09740
    Location:505 → 608
    DUF2043; Uncharacterized conserved protein (DUF2043)

RNA

  1. NR_153107.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC145072, AK040506
    Related
    ENSMUST00000202046.4

  2. NR_153108.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC145072

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    33535868..33578243
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006504109.3 → XP_006504172.1  UV-stimulated scaffold protein A isoform X2

    Conserved Domains (1) summary
    pfam09740
    Location:291 → 394
    DUF2043; Uncharacterized conserved protein (DUF2043)

  2. XM_006504108.5 → XP_006504171.1  UV-stimulated scaffold protein A isoform X1

    See identical proteins and their annotated locations for XP_006504171.1

    UniProtKB/Swiss-Prot
    B2RQ84, B7ZN03, Q3U1A8, Q6P7V8, Q6ZPN7, Q9D479
    Conserved Domains (1) summary
    pfam09740
    Location:505 → 608
    DUF2043; Uncharacterized conserved protein (DUF2043)

RNA

  1. XR_004942561.1 RNA Sequence

  2. XR_004942560.1 RNA Sequence

  3. XR_003955710.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D479.2 GenPept UniProtKB/Swiss-Prot:Q9D479

Gene LinkOut

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