U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Ttc6 tetratricopeptide repeat domain 6 [ Mus musculus (house mouse) ]

Gene ID: 70846, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
Ttc6provided by MGI
Official Full Name
tetratricopeptide repeat domain 6provided by MGI
Primary source
MGI:MGI:2684915
See related
Ensembl:ENSMUSG00000046782 AllianceGenome:MGI:2684915
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm69; Gm9813; EG639426; 4921506M07Rik
Summary
Is expressed in several structures, including floor plate; future midbrain; midbrain roof plate; notochord; and trachea. Orthologous to human TTC6 (tetratricopeptide repeat domain 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 5.1), bladder adult (RPKM 3.5) and 5 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
12 C1; 12 24.7 cM
Exon count:
35
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (57593490..57784697)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (57546704..57737911)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_32225 Neighboring gene predicted gene, 20016 Neighboring gene TAR DNA-binding protein 43 pseudogene Neighboring gene RIKEN cDNA 4921518K17 gene Neighboring gene forkhead box A1 Neighboring gene predicted gene, 30518 Neighboring gene ribosomal protein L26, pseudogene 2 Neighboring gene STARR-seq mESC enhancer starr_32227 Neighboring gene cDNA sequence BC042761 Neighboring gene STARR-seq mESC enhancer starr_32229 Neighboring gene predicted gene, 46329 Neighboring gene STARR-seq mESC enhancer starr_32231 Neighboring gene somatostatin receptor 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Integrated microarray and ChIP analysis identifies multiple Foxa2 dependent target genes in the notochord. Tamplin OJ, et al. Dev Biol, 2011 Dec 15. PMID 22008794
  2. Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo. Evsikov AV, et al. Genes Dev, 2006 Oct 1. PMID 17015433, Free PMC Article
  3. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
  4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TTC6-Mediated Stabilization of the Flagellum Annulus Ensures the Rapid and Directed Motion of Sperm.
    Title: TTC6-Mediated Stabilization of the Flagellum Annulus Ensures the Rapid and Directed Motion of Sperm.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Go to the top of the page Help

Homology

Clone Names

  • MGC118322

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

Go to the top of the page Help
Preferred Names
tetratricopeptide repeat protein 6

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001312644.1 → NP_001299573.1  tetratricopeptide repeat protein 6

    Status: VALIDATED

    Source sequence(s)
    AC123067, AC123943, AI447953, AK014828, AV271916, BB616183, DV662015
    Consensus CDS
    CCDS83963.1
    UniProtKB/TrEMBL
    G3UYY4
    Conserved Domains (4) summary
    TIGR02521
    Location:1680 → 1852
    type_IV_pilW; type IV pilus biogenesis/stability protein PilW
    PTZ00436
    Location:13 → 178
    PTZ00436; 60S ribosomal protein L19-like protein; Provisional
    TIGR02917
    Location:896 → 1760
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:1341 → 1369
    TPR; TPR repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    57593490..57784697
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017315184.2 → XP_017170673.1  tetratricopeptide repeat protein 6 isoform X1

    UniProtKB/TrEMBL
    G3UYY4
    Related
    ENSMUSP00000134273.2, ENSMUST00000172939.8
    Conserved Domains (4) summary
    TIGR02521
    Location:1680 → 1852
    type_IV_pilW; type IV pilus biogenesis/stability protein PilW
    PTZ00436
    Location:13 → 178
    PTZ00436; 60S ribosomal protein L19-like protein; Provisional
    TIGR02917
    Location:896 → 1760
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:1341 → 1369
    TPR; TPR repeat [structural motif]

  2. XM_017315185.2 → XP_017170674.1  tetratricopeptide repeat protein 6 isoform X2

    Conserved Domains (4) summary
    TIGR02521
    Location:1630 → 1802
    type_IV_pilW; type IV pilus biogenesis/stability protein PilW
    PTZ00436
    Location:13 → 178
    PTZ00436; 60S ribosomal protein L19-like protein; Provisional
    TIGR02917
    Location:896 → 1710
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:1635 → 1663
    TPR; TPR repeat [structural motif]

  3. XM_017315187.2 → XP_017170676.1  tetratricopeptide repeat protein 6 isoform X4

    Conserved Domains (4) summary
    TIGR02521
    Location:1487 → 1659
    type_IV_pilW; type IV pilus biogenesis/stability protein PilW
    PTZ00436
    Location:13 → 178
    PTZ00436; 60S ribosomal protein L19-like protein; Provisional
    TIGR02917
    Location:895 → 1567
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:1148 → 1176
    TPR; TPR repeat [structural motif]

  4. XM_017315186.2 → XP_017170675.1  tetratricopeptide repeat protein 6 isoform X3

    Conserved Domains (3) summary
    PTZ00436
    Location:13 → 178
    PTZ00436; 60S ribosomal protein L19-like protein; Provisional
    TIGR02917
    Location:896 → 1745
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:1341 → 1369
    TPR; TPR repeat [structural motif]

  5. XM_017315188.3 → XP_017170677.1  tetratricopeptide repeat protein 6 isoform X5

    Conserved Domains (4) summary
    PTZ00436
    Location:13 → 178
    PTZ00436; 60S ribosomal protein L19-like protein; Provisional
    TIGR02917
    Location:896 → 1480
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:1341 → 1369
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:1477 → 1539
    TPR_12; Tetratricopeptide repeat

  6. XM_017315191.2 → XP_017170680.1  tetratricopeptide repeat protein 6 isoform X8

    Conserved Domains (4) summary
    PTZ00436
    Location:13 → 178
    PTZ00436; 60S ribosomal protein L19-like protein; Provisional
    COG0457
    Location:884 → 1113
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    TIGR02917
    Location:1024 → 1235
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:1023 → 1051
    TPR; TPR repeat [structural motif]

  7. XM_017315193.2 → XP_017170682.1  tetratricopeptide repeat protein 6 isoform X10

    Conserved Domains (3) summary
    COG0457
    Location:865 → 958
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:887 → 918
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:889 → 916
    TPR_1; Tetratricopeptide repeat

  8. XM_017315192.2 → XP_017170681.1  tetratricopeptide repeat protein 6 isoform X9

    Conserved Domains (2) summary
    COG0457
    Location:865 → 1016
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:889 → 917
    TPR; TPR repeat [structural motif]

  9. XM_030246911.2 → XP_030102771.1  tetratricopeptide repeat protein 6 isoform X7

    Conserved Domains (3) summary
    COG4783
    Location:1231 → 1390
    YfgC; Putative Zn-dependent protease, contains TPR repeats [General function prediction only]
    TIGR02917
    Location:436 → 1300
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:881 → 909
    TPR; TPR repeat [structural motif]

  10. XM_017315189.3 → XP_017170678.1  tetratricopeptide repeat protein 6 isoform X6

    Conserved Domains (3) summary
    COG4783
    Location:1397 → 1556
    YfgC; Putative Zn-dependent protease, contains TPR repeats [General function prediction only]
    TIGR02917
    Location:602 → 1466
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:1047 → 1075
    TPR; TPR repeat [structural motif]

  11. XM_030246912.2 → XP_030102772.1  tetratricopeptide repeat protein 6 isoform X12

    Conserved Domains (4) summary
    COG0457
    Location:1 → 213
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    TIGR00990
    Location:110 → 323
    3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
    TIGR02917
    Location:253 → 646
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:480 → 508
    TPR; TPR repeat [structural motif]

  12. XM_017315194.2 → XP_017170683.1  tetratricopeptide repeat protein 6 isoform X11

    Conserved Domains (3) summary
    COG4783
    Location:693 → 852
    YfgC; Putative Zn-dependent protease, contains TPR repeats [General function prediction only]
    TIGR02917
    Location:23 → 762
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:687 → 715
    TPR; TPR repeat [structural motif]

RNA

  1. XR_001780477.2 RNA Sequence

  2. XR_001780479.2 RNA Sequence

  3. XR_001780482.2 RNA Sequence

  4. XR_001780478.2 RNA Sequence

  5. XR_001780481.2 RNA Sequence

  6. XR_001780480.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001037743.1: Suppressed sequence

    Description
    NM_001037743.1: This RefSeq was removed because the CDS was partial.
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous