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Gulp1 GULP, engulfment adaptor PTB domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 70676, updated on 5-Mar-2024

Summary

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Official Symbol
Gulp1provided by MGI
Official Full Name
GULP, engulfment adaptor PTB domain containing 1provided by MGI
Primary source
MGI:MGI:1920407
See related
Ensembl:ENSMUSG00000056870 AllianceGenome:MGI:1920407
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ced6; GULP; CED-6; Gulp-2; 3110030A04Rik; 5730529O06Rik
Summary
Predicted to act upstream of or within phagocytosis, engulfment. Predicted to be located in cytoplasm. Is expressed in genitourinary system. Orthologous to human GULP1 (GULP PTB domain containing engulfment adaptor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in limb E14.5 (RPKM 12.2), bladder adult (RPKM 6.3) and 17 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 C1.1; 1 23.63 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (44590540..44835998)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (44551380..44796838)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_00802 Neighboring gene STARR-seq mESC enhancer starr_00803 Neighboring gene STARR-seq mESC enhancer starr_00804 Neighboring gene predicted gene 28893 Neighboring gene thioredoxin, pseudogene 1 Neighboring gene predicted gene, 39635 Neighboring gene STARR-seq mESC enhancer starr_00806 Neighboring gene STARR-seq mESC enhancer starr_00807 Neighboring gene STARR-seq mESC enhancer starr_00808 Neighboring gene voltage-dependent anion channel 1 pseudogene Neighboring gene RIKEN cDNA 4930521E06 gene Neighboring gene STARR-seq mESC enhancer starr_00809 Neighboring gene predicted gene 3489 Neighboring gene predicted gene, 19480

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Gulp1 deficiency augments bone mass in male mice by affecting osteoclasts due to elevated 17β-estradiol levels. Kim SY, et al. J Cell Physiol, 2023 May. PMID 36870066
  2. The adaptor protein GULP promotes Jedi-1-mediated phagocytosis through a clathrin-dependent mechanism. Sullivan CS, et al. Mol Biol Cell, 2014 Jun 15. PMID 24743597, Free PMC Article
  3. Identification of a mouse orthologue of the CED-6 gene of Caenorhabditis elegans. Banerjee H, et al. Plasmid, 2003 Jan. PMID 12583998
  4. Signalling pathway involving GULP, MAPK and Rac1 for SR-BI-induced phagocytosis of apoptotic cells. Osada Y, et al. J Biochem, 2009 Mar. PMID 19122200
  5. Interaction of CED-6/GULP, an adapter protein involved in engulfment of apoptotic cells with CED-1 and CD91/low density lipoprotein receptor-related protein (LRP). Su HP, et al. J Biol Chem, 2002 Apr 5. PMID 11729193

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GULP1 deficiency reduces adipogenesis and glucose uptake via downregulation of PPAR signaling and disturbing of insulin/ERK signaling in 3T3-L1 cells.
    Title: GULP1 deficiency reduces adipogenesis and glucose uptake via downregulation of PPAR signaling and disturbing of insulin/ERK signaling in 3T3-L1 cells.
  2. Gulp1 deficiency augments bone mass in male mice by affecting osteoclasts due to elevated 17beta-estradiol levels.
    Title: Gulp1 deficiency augments bone mass in male mice by affecting osteoclasts due to elevated 17β-estradiol levels.
  3. Jedi-1 signals through recruitment of GULP, which promotes phagocytosis through a noncanonical phosphoclathrin-dependent mechanism.
    Title: The adaptor protein GULP promotes Jedi-1-mediated phagocytosis through a clathrin-dependent mechanism.
  4. Phosphatidylserine-recognizing SR-BI activates associated GULP; activated GULP induces MAPK phosphorylation; activated MAPK increases GTP-bound Rac1; and activated Rac1 induces a rearrangement of the actin cytoskeleton.
    Title: Signalling pathway involving GULP, MAPK and Rac1 for SR-BI-induced phagocytosis of apoptotic cells.
  5. in this study we report the identification of a novel C. elegans CED-6-like orthologue in mouse, which has probable apoptotic like function
    Title: Identification of a mouse orthologue of the CED-6 gene of Caenorhabditis elegans.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within phagocytosis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within phagocytosis, engulfment ISO
Inferred from Sequence Orthology
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
PTB domain-containing engulfment adapter protein 1
Names
CED 6
PTB domain adapter protein CED-6
cell death protein 6 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028450.3 → NP_082726.2  PTB domain-containing engulfment adapter protein 1

    See identical proteins and their annotated locations for NP_082726.2

    Status: VALIDATED

    Source sequence(s)
    AK036670, BE632215, BY713087
    Consensus CDS
    CCDS48250.1
    UniProtKB/Swiss-Prot
    Q8K2A1, Q9CRV4, Q9CYD2
    UniProtKB/TrEMBL
    Q0PNF0
    Related
    ENSMUSP00000074115.4, ENSMUST00000074525.10
    Conserved Domains (3) summary
    cd01273
    Location:14 → 157
    PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain
    pfam04880
    Location:167 → 258
    NUDE_C; NUDE protein, C-terminal conserved region
    pfam10211
    Location:135 → 198
    Ax_dynein_light; Axonemal dynein light chain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    44590540..44835998
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006496277.4 → XP_006496340.1  PTB domain-containing engulfment adapter protein 1 isoform X2

    UniProtKB/TrEMBL
    E0CXC5, Q0PNF0
    Related
    ENSMUSP00000124756.2, ENSMUST00000162600.2
    Conserved Domains (2) summary
    cd01273
    Location:14 → 157
    PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain
    pfam10211
    Location:136 → 206
    Ax_dynein_light; Axonemal dynein light chain

  2. XM_006496276.4 → XP_006496339.1  PTB domain-containing engulfment adapter protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006496339.1

    UniProtKB/TrEMBL
    Q0PNF0
    Conserved Domains (2) summary
    cd01273
    Location:14 → 157
    PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain
    pfam10211
    Location:136 → 206
    Ax_dynein_light; Axonemal dynein light chain

  3. XM_006496278.4 → XP_006496341.1  PTB domain-containing engulfment adapter protein 1 isoform X3

    UniProtKB/TrEMBL
    Q0PNF0
    Conserved Domains (3) summary
    cd01273
    Location:14 → 157
    PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain
    pfam04880
    Location:167 → 246
    NUDE_C; NUDE protein, C-terminal conserved region
    pfam10211
    Location:136 → 198
    Ax_dynein_light; Axonemal dynein light chain

  4. XM_011238599.3 → XP_011236901.1  PTB domain-containing engulfment adapter protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011236901.1

    UniProtKB/TrEMBL
    Q0PNF0
    Conserved Domains (2) summary
    cd01273
    Location:14 → 157
    PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain
    pfam10211
    Location:136 → 206
    Ax_dynein_light; Axonemal dynein light chain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_027506.2: Suppressed sequence

    Description
    NM_027506.2: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K2A1.1 GenPept UniProtKB/Swiss-Prot:Q8K2A1

Gene LinkOut

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