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Sugp1 SURP and G patch domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 70616, updated on 5-Mar-2024

Summary

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Official Symbol
Sugp1provided by MGI
Official Full Name
SURP and G patch domain containing 1provided by MGI
Primary source
MGI:MGI:1917866
See related
Ensembl:ENSMUSG00000011306 AllianceGenome:MGI:1917866
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sf4; 5730496N02Rik
Summary
Predicted to enable RNA binding activity. Predicted to be involved in RNA processing. Predicted to act upstream of or within RNA splicing and mRNA processing. Predicted to be located in nucleoplasm. Predicted to be part of spliceosomal complex. Orthologous to human SUGP1 (SURP and G-patch domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 15.9), CNS E14 (RPKM 11.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Sugp1 in Genome Data Viewer
Location:
8 B3.3; 8 34.15 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (70495435..70524997)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (70042769..70072347)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_21762 Neighboring gene nucleoside diphosphate kinase B pseudogene Neighboring gene MAU2 sister chromatid cohesion factor Neighboring gene STARR-positive B cell enhancer ABC_E9314 Neighboring gene transmembrane 6 superfamily member 2 Neighboring gene hyaluronan and proteoglycan link protein 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. SUGP1 is a novel regulator of cholesterol metabolism. Kim MJ, et al. Hum Mol Genet, 2016 Jul 15. PMID 27206982, Free PMC Article
  2. SF4 and SFRS14, two related putative splicing factors on human chromosome 19p13.11. Sampson ND, et al. Gene, 2003 Feb 13. PMID 12594045
  3. Transcription factor Foxp3 and its protein partners form a complex regulatory network. Rudra D, et al. Nat Immunol, 2012 Oct. PMID 22922362, Free PMC Article
  4. Complementary proteomics strategies capture an ataxin-1 interactome in Neuro-2a cells. Zhang S, et al. Sci Data, 2018 Nov 20. PMID 30457570, Free PMC Article
  5. ATG5 is required for B cell polarization and presentation of particulate antigens. Arbogast F, et al. Autophagy, 2019 Feb. PMID 30196744, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in RNA processing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within RNA splicing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of spliceosomal complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
SURP and G-patch domain-containing protein 1
Names
splicing factor 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001368391.1 → NP_001355320.1  SURP and G-patch domain-containing protein 1

    Status: VALIDATED

    Source sequence(s)
    AC167132
    Consensus CDS
    CCDS22356.1
    UniProtKB/Swiss-Prot
    Q0VAT9, Q3U0W3, Q8CH02, Q8R094

  2. NM_027481.3 → NP_081757.1  SURP and G-patch domain-containing protein 1

    See identical proteins and their annotated locations for NP_081757.1

    Status: VALIDATED

    Source sequence(s)
    AC167132
    Consensus CDS
    CCDS22356.1
    UniProtKB/Swiss-Prot
    Q0VAT9, Q3U0W3, Q8CH02, Q8R094
    Related
    ENSMUSP00000011450.7, ENSMUST00000011450.8
    Conserved Domains (2) summary
    pfam01585
    Location:561 → 605
    G-patch; G-patch domain
    pfam01805
    Location:186 → 237
    Surp; Surp module

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    70495435..70524997
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030243755.2 → XP_030099615.1  SURP and G-patch domain-containing protein 1 isoform X1

    Conserved Domains (3) summary
    PRK12270
    Location:335 → 458
    kgd; multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit
    pfam01585
    Location:603 → 645
    G-patch; G-patch domain
    pfam01805
    Location:227 → 278
    Surp; Surp module

  2. XM_036154283.1 → XP_036010176.1  SURP and G-patch domain-containing protein 1 isoform X2

    Conserved Domains (3) summary
    PRK12270
    Location:87 → 210
    kgd; multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit
    pfam01585
    Location:355 → 399
    G-patch; G-patch domain
    pfam01805
    Location:55 → 106
    Surp; Surp module
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CH02.1 GenPept UniProtKB/Swiss-Prot:Q8CH02

Gene LinkOut

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