U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Slc35d2 solute carrier family 35, member D2 [ Mus musculus (house mouse) ]

Gene ID: 70484, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Slc35d2provided by MGI
Official Full Name
solute carrier family 35, member D2provided by MGI
Primary source
MGI:MGI:1917734
See related
Ensembl:ENSMUSG00000033114 AllianceGenome:MGI:1917734
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
hfrc; SQV7L; UGTrel8; mUGTrel8; 5730408I21Rik
Summary
Predicted to enable antiporter activity and pyrimidine nucleotide-sugar transmembrane transporter activity. Predicted to act upstream of or within carbohydrate transport. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus. Orthologous to human SLC35D2 (solute carrier family 35 member D2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver adult (RPKM 6.4), bladder adult (RPKM 3.9) and 21 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Slc35d2 in Genome Data Viewer
Location:
13 B3; 13 33.26 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (64244122..64277195, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (64096308..64129381, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30999 Neighboring gene hydroxysteroid (17-beta) dehydrogenase 3 Neighboring gene zinc finger protein 367 Neighboring gene STARR-seq mESC enhancer starr_34820 Neighboring gene STARR-positive B cell enhancer ABC_E5404 Neighboring gene STARR-positive B cell enhancer ABC_E928 Neighboring gene STARR-positive B cell enhancer ABC_E7250 Neighboring gene hyaluronic acid binding protein 4

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Identification and characterization of human Golgi nucleotide sugar transporter SLC35D2, a novel member of the SLC35 nucleotide sugar transporter family. Ishida N, et al. Genomics, 2005 Jan. PMID 15607426
  2. Molecular cloning and characterization of a human multisubstrate specific nucleotide-sugar transporter homologous to Drosophila fringe connection. Suda T, et al. J Biol Chem, 2004 Jun 18. PMID 15082721
  3. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
  4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC130109, MGC130110

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables UDP-N-acetylgalactosamine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables UDP-N-acetylglucosamine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables UDP-N-acetylglucosamine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables UDP-glucose transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables UDP-glucuronic acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables antiporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleotide-sugar transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within UDP-glucose transmembrane transport ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within carbohydrate transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_positive_effect heparan sulfate proteoglycan biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in nucleotide-sugar transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
is_active_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
nucleotide sugar transporter SLC35D2
Names
UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter
UDP-galactose transporter-related protein 8
UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001321.3 → NP_001001321.2  nucleotide sugar transporter SLC35D2

    See identical proteins and their annotated locations for NP_001001321.2

    Status: PROVISIONAL

    Source sequence(s)
    AK159148
    Consensus CDS
    CCDS26595.1
    UniProtKB/Swiss-Prot
    Q3TXR0, Q762D4, Q762D5, Q811G6
    UniProtKB/TrEMBL
    A0A0R4J181
    Related
    ENSMUSP00000097040.5, ENSMUST00000099441.6
    Conserved Domains (1) summary
    pfam03151
    Location:16 → 301
    TPT; Triose-phosphate Transporter family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    64244122..64277195 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006517373.4 → XP_006517436.1  nucleotide sugar transporter SLC35D2 isoform X3

    UniProtKB/Swiss-Prot
    Q3TXR0, Q762D4, Q762D5, Q811G6
    Conserved Domains (1) summary
    cl26744
    Location:55 → 238
    TPT; Triose-phosphate Transporter family

  2. XM_006517372.4 → XP_006517435.1  nucleotide sugar transporter SLC35D2 isoform X1

    UniProtKB/Swiss-Prot
    Q3TXR0, Q762D4, Q762D5, Q811G6
    UniProtKB/TrEMBL
    A0A1Y7VL74
    Related
    ENSMUSP00000152341.2, ENSMUST00000220792.2
    Conserved Domains (1) summary
    cl26744
    Location:16 → 228
    TPT; Triose-phosphate Transporter family

  3. XM_006517374.4 → XP_006517437.1  nucleotide sugar transporter SLC35D2 isoform X4

    Conserved Domains (1) summary
    cl26744
    Location:12 → 195
    TPT; Triose-phosphate Transporter family

  4. XM_036158165.1 → XP_036014058.1  nucleotide sugar transporter SLC35D2 isoform X4

    Conserved Domains (1) summary
    cl26744
    Location:12 → 195
    TPT; Triose-phosphate Transporter family

  5. XM_036158164.1 → XP_036014057.1  nucleotide sugar transporter SLC35D2 isoform X2

    UniProtKB/Swiss-Prot
    Q3TXR0, Q762D4, Q762D5, Q811G6
    Conserved Domains (1) summary
    cl26744
    Location:2 → 249
    TPT; Triose-phosphate Transporter family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q762D5.1 GenPept UniProtKB/Swiss-Prot:Q762D5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous