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Spata3 spermatogenesis associated 3 [ Mus musculus (house mouse) ]

Gene ID: 70060, updated on 5-Mar-2024

Summary

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Official Symbol
Spata3provided by MGI
Official Full Name
spermatogenesis associated 3provided by MGI
Primary source
MGI:MGI:1917310
See related
Ensembl:ENSMUSG00000026226 AllianceGenome:MGI:1917310
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tsarg1; Mtsarg1; 1700011N12Rik; 1700029H01Rik; 4930424D10Rik
Summary
Orthologous to human SPATA3 (spermatogenesis associated 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis adult (RPKM 155.9) See more
Orthologs
human all
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Genomic context

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See Spata3 in Genome Data Viewer
Location:
1 C5; 1 43.94 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (85945728..85957683)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (86018031..86029961)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5777 Neighboring gene predicted gene, 53569 Neighboring gene zinc finger protein 617 pseudogene Neighboring gene RIKEN cDNA 2810459M11 gene Neighboring gene STARR-positive B cell enhancer ABC_E1552 Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 Neighboring gene predicted gene, 22786

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Deletion of the Spata3 Gene Induces Sperm Alterations and In Vitro Hypofertility in Mice. Girault MS, et al. Int J Mol Sci, 2021 Feb 16. PMID 33669425, Free PMC Article
  2. Molecular cloning and characterization of a novel transcript variant of Mtsarg1 gene. Li L, et al. Mol Biol Rep, 2009 May. PMID 18551385
  3. [Molecular cloning for testis spermatogenesis cell apoptosis related gene TSARG1 and Mtsarg1 and expression analysis for Mtsarg1 gene]. Fu JJ, et al. Yi Chuan Xue Bao, 2003 Jan. PMID 12812072
  4. Identification of host proteins, Spata3 and Dkk2, interacting with Toxoplasma gondii micronemal protein MIC3. Wang Y, et al. Parasitol Res, 2016 Jul. PMID 27053129
  5. Evidence Implicating CCNB1IP1, a RING Domain-Containing Protein Required for Meiotic Crossing Over in Mice, as an E3 SUMO Ligase. Strong ER, et al. Genes (Basel), 2010 Dec 2. PMID 21779533, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Deletion of the Spata3 Gene Induces Sperm Alterations and In Vitro Hypofertility in Mice.
    Title: Deletion of the Spata3 Gene Induces Sperm Alterations and In Vitro Hypofertility in Mice.
  2. Spermatogenesis-associated protein 3 (Spata3) and dickkopf-related protein 2 (Dkk2) were confirmed to interact with MIC3. The tandem repeat EGF domains of MIC3 were critical in mediating the interactions with the identified host proteins. The results show that MIC3 interacts with host proteins that are involved in reproduction, growth, and development.
    Title: Identification of host proteins, Spata3 and Dkk2, interacting with Toxoplasma gondii micronemal protein MIC3.
  3. Mtsarg1 and Mtsarg1-beta may play an important role in mouse testicular function and in spermatocyte development.
    Title: Molecular cloning and characterization of a novel transcript variant of Mtsarg1 gene.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
spermatogenesis-associated protein 3
Names
testis and spermatogenesis cell apoptosis related gene 1
testis and spermatogenesis cell apoptosis related protein 1
testis and spermatogenesis cell-related protein 1
testis spermatocyte apoptosis-related protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001122732.2 → NP_001116204.1  spermatogenesis-associated protein 3 isoform 3

    See identical proteins and their annotated locations for NP_001116204.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses a different splice site in the CDS, compared to variant 2. The resulting isoform (3) lacks one amino acid when it is compared to isoform 2. Variants 3 and 4 both encode the same isoform (3).
    Source sequence(s)
    AC102506
    Consensus CDS
    CCDS15116.1
    UniProtKB/TrEMBL
    F6UTK3, Q3V2M5
    Related
    ENSMUSP00000116903.2, ENSMUST00000130504.8
    Conserved Domains (1) summary
    pfam15662
    Location:9 → 191
    SPATA3; Spermatogenesis-associated protein 3 family

  2. NM_001379365.1 → NP_001366294.1  spermatogenesis-associated protein 3 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5), as well as variant 2, encodes the longest isoform (2).
    Source sequence(s)
    AC102506
    UniProtKB/Swiss-Prot
    Q80ZS4, Q9D5L5, Q9D9T6, Q9DAF5
    UniProtKB/TrEMBL
    F6UTK3
    Related
    ENSMUSP00000124671.2, ENSMUST00000159876.8
    Conserved Domains (1) summary
    pfam15662
    Location:9 → 192
    SPATA3; Spermatogenesis-associated protein 3 family

  3. NM_027029.3 → NP_081305.1  spermatogenesis-associated protein 3 isoform 1

    See identical proteins and their annotated locations for NP_081305.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) uses two different splice sites in the CDS and a different segment for its 3' UTR, compared to variant 2. The resulting isoform (1) has a shorter and distinct C-terminus compared to isoform 2.
    Source sequence(s)
    AC102506
    Consensus CDS
    CCDS48301.1
    UniProtKB/TrEMBL
    Q6P8X3
    Related
    ENSMUSP00000123194.2, ENSMUST00000152501.8
    Conserved Domains (1) summary
    pfam15662
    Location:9 → 158
    SPATA3; Spermatogenesis-associated protein 3 family

  4. NM_027300.4 → NP_081576.2  spermatogenesis-associated protein 3 isoform 2

    See identical proteins and their annotated locations for NP_081576.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents the longest transcript and encodes the longest isoform (2). Variants 2 and 5 both encode the same isoform (2).
    Source sequence(s)
    AC102506
    Consensus CDS
    CCDS35643.1
    UniProtKB/Swiss-Prot
    Q80ZS4, Q9D5L5, Q9D9T6, Q9DAF5
    UniProtKB/TrEMBL
    F6UTK3
    Related
    ENSMUSP00000050509.7, ENSMUST00000052854.13
    Conserved Domains (1) summary
    pfam15662
    Location:9 → 192
    SPATA3; Spermatogenesis-associated protein 3 family

  5. NM_028647.5 → NP_082923.1  spermatogenesis-associated protein 3 isoform 3

    See identical proteins and their annotated locations for NP_082923.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses a different splice site in the CDS and a different segment for its 3' UTR, compared to variant 2. The resulting protein isoform (3) lacks one amino acid when it is compared to isoform 2. Variants 3 and 4 both encode the same isoform (3).
    Source sequence(s)
    AC102506
    Consensus CDS
    CCDS15116.1
    UniProtKB/TrEMBL
    F6UTK3, Q3V2M5
    Related
    ENSMUSP00000108971.2, ENSMUST00000113344.8
    Conserved Domains (1) summary
    pfam15662
    Location:9 → 191
    SPATA3; Spermatogenesis-associated protein 3 family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    85945728..85957683
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030242863.2 → XP_030098723.2  spermatogenesis-associated protein 3 isoform X4

    Conserved Domains (1) summary
    pfam15443
    Location:192 → 253
    DUF4630; Domain of unknown function (DUF4630)

  2. XM_011248072.4 → XP_011246374.3  spermatogenesis-associated protein 3 isoform X5

  3. XM_030242861.2 → XP_030098721.2  spermatogenesis-associated protein 3 isoform X3

  4. XM_036153549.1 → XP_036009442.1  spermatogenesis-associated protein 3 isoform X3

  5. XM_030242857.2 → XP_030098717.1  spermatogenesis-associated protein 3 isoform X1

    Conserved Domains (1) summary
    pfam15662
    Location:110 → 293
    SPATA3; Spermatogenesis-associated protein 3 family

  6. XM_030242858.2 → XP_030098718.1  spermatogenesis-associated protein 3 isoform X2

    Conserved Domains (1) summary
    pfam15662
    Location:110 → 292
    SPATA3; Spermatogenesis-associated protein 3 family

  7. XM_011248071.4 → XP_011246373.1  spermatogenesis-associated protein 3 isoform X1

    Conserved Domains (1) summary
    pfam15662
    Location:110 → 293
    SPATA3; Spermatogenesis-associated protein 3 family

  8. XM_030242859.2 → XP_030098719.1  spermatogenesis-associated protein 3 isoform X2

    Conserved Domains (1) summary
    pfam15662
    Location:110 → 292
    SPATA3; Spermatogenesis-associated protein 3 family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D9T6.2 GenPept UniProtKB/Swiss-Prot:Q9D9T6

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