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Ace2 angiotensin converting enzyme 2 [ Mus musculus (house mouse) ]

Gene ID: 70008, updated on 21-Apr-2024

Summary

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Official Symbol
Ace2provided by MGI
Official Full Name
angiotensin converting enzyme 2provided by MGI
Primary source
MGI:MGI:1917258
See related
Ensembl:ENSMUSG00000015405 AllianceGenome:MGI:1917258
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2010305L05Rik
Summary
Predicted to enable identical protein binding activity; peptidase activity; and virus receptor activity. Involved in positive regulation of cardiac muscle contraction and tryptophan transport. Located in brush border membrane and cytoplasm. Is expressed in several structures, including brain; cardiovascular system; extraembryonic component; genitourinary system; and respiratory system. Used to study COVID-19 and congestive heart failure. Human ortholog(s) of this gene implicated in several diseases, including avian influenza; cerebral malaria; hypertension (multiple); respiratory syncytial virus infectious disease; and severe acute respiratory syndrome. Orthologous to human ACE2 (angiotensin converting enzyme 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in large intestine adult (RPKM 49.9), small intestine adult (RPKM 19.5) and 3 other tissues See more
Orthologs
human all
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Genomic context

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Location:
X F5; X 76.12 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (162922338..162971414)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (164139342..164188418)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1986 Neighboring gene siah E3 ubiquitin protein ligase 1B Neighboring gene collectrin, amino acid transport regulator Neighboring gene STARR-seq mESC enhancer starr_48236 Neighboring gene BMX non-receptor tyrosine kinase Neighboring gene predicted gene, 19251 Neighboring gene STARR-seq mESC enhancer starr_48237 Neighboring gene predicted gene, 46692 Neighboring gene pirin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Activation of angiotensin-converting enzyme 2 produces an antidepressant-like effect via MAS receptors in mice. Nakagawasai O, et al. Mol Brain, 2023 Jun 13. PMID 37312182, Free PMC Article
  2. Intestinal ACE2 regulates glucose metabolism in diet-induced obese mice through a novel gut-islet axis mediated by tryptophan. Chen Q, et al. Obesity (Silver Spring), 2023 May. PMID 36998145
  3. Identification of the regulatory mechanism of ACE2 in COVID-19-induced kidney damage with systems genetics approach. Yang X, et al. J Mol Med (Berl), 2023 Apr. PMID 36951969, Free PMC Article
  4. Cell-autonomous requirement for ACE2 across organs in lethal mouse SARS-CoV-2 infection. Tang AT, et al. PLoS Biol, 2023 Feb. PMID 36745682, Free PMC Article
  5. A SARS-CoV-2-Related Virus from Malayan Pangolin Causes Lung Infection without Severe Disease in Human ACE2-Transgenic Mice. Liu MQ, et al. J Virol, 2023 Feb 28. PMID 36688655, Free PMC Article

See all (297) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Angiotensin-converting enzyme 2 alleviates liver fibrosis through the renin-angiotensin system.
    Title: Angiotensin-converting enzyme 2 alleviates liver fibrosis through the renin-angiotensin system.
  2. ACE2 improves endothelial cell function and reduces acute lung injury by downregulating FAK expression.
    Title: ACE2 improves endothelial cell function and reduces acute lung injury by downregulating FAK expression.
  3. ACE2 activation alleviates sepsis-induced cardiomyopathy by promoting MasR-Sirt1-mediated mitochondrial biogenesis.
    Title: ACE2 activation alleviates sepsis-induced cardiomyopathy by promoting MasR-Sirt1-mediated mitochondrial biogenesis.
  4. Adaptation of SARS-CoV-2 to ACE2H353K mice reveals new spike residues that drive mouse infection.
    Title: Adaptation of SARS-CoV-2 to ACE2(H353K) mice reveals new spike residues that drive mouse infection.
  5. Generation and characterization of a humanized ACE2 mouse model to study long-term impacts of SARS-CoV-2 infection.
    Title: Generation and characterization of a humanized ACE2 mouse model to study long-term impacts of SARS-CoV-2 infection.
  6. Angiotensin-converting enzyme 2 improves liver fibrosis in mice by regulating autophagy of hepatic stellate cells.
    Title: Angiotensin-converting enzyme 2 improves liver fibrosis in mice by regulating autophagy of hepatic stellate cells.
  7. Lymphocytes regulate expression of the SARS-CoV-2 cell entry factor ACE2 in the pancreas of T2DM patients.
    Title: Lymphocytes regulate expression of the SARS-CoV-2 cell entry factor ACE2 in the pancreas of T2DM patients.
  8. Altered renin-angiotensin system gene expression in airways of antigen-challenged mice: ACE2 downregulation and unexpected increase in angiotensin 1-7.
    Title: Altered renin-angiotensin system gene expression in airways of antigen-challenged mice: ACE2 downregulation and unexpected increase in angiotensin 1-7.
  9. Nedd4-2 up-regulation is associated with ACE2 ubiquitination in hypertension.
    Title: Nedd4-2 up-regulation is associated with ACE2 ubiquitination in hypertension.
  10. Angiotensin deficient FVB/N mice are normotensive.
    Title: Angiotensin deficient FVB/N mice are normotensive.
Submit: New GeneRIF Correction See all GeneRIFs (172)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carboxypeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables carboxypeptidase activity TAS
Traceable Author Statement
more info
 PubMed 
enables endopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metallocarboxypeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables metallopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metallopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidyl-dipeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables virus receptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in angiotensin-mediated drinking behavior ISO
Inferred from Sequence Orthology
more info
  
involved_in entry receptor-mediated virion attachment to host cell ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of negative regulation of signaling receptor activity ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of L-proline import across plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of amino acid transport ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cardiac muscle contraction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of gap junction assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in receptor-mediated virion attachment to host cell ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cardiac conduction ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of systemic arterial blood pressure by renin-angiotensin ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_positive_effect symbiont entry into host cell ISO
Inferred from Sequence Orthology
more info
  
involved_in tryptophan transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in brush border membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in brush border membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
angiotensin-converting enzyme 2
Names
ACE-related carboxypeptidase
angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
angiotensin I converting enzyme 2
NP_001123985.1
NP_081562.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130513.1 → NP_001123985.1  angiotensin-converting enzyme 2 precursor

    See identical proteins and their annotated locations for NP_001123985.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript.
    Source sequence(s)
    AK141604, BY722909
    Consensus CDS
    CCDS30518.1
    UniProtKB/Swiss-Prot
    Q8R0I0, Q99N70, Q99N71
    UniProtKB/TrEMBL
    C7ECU2, Q3URC9
    Related
    ENSMUSP00000107890.4, ENSMUST00000112271.10
    Conserved Domains (2) summary
    pfam01401
    Location:21 → 606
    Peptidase_M2; Angiotensin-converting enzyme
    pfam16959
    Location:617 → 770
    Collectrin; Renal amino acid transporter

  2. NM_027286.4 → NP_081562.2  angiotensin-converting enzyme 2 precursor

    See identical proteins and their annotated locations for NP_081562.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1.
    Source sequence(s)
    AI115946, AK141604
    Consensus CDS
    CCDS30518.1
    UniProtKB/Swiss-Prot
    Q8R0I0, Q99N70, Q99N71
    UniProtKB/TrEMBL
    C7ECU2, Q3URC9
    Related
    ENSMUSP00000073626.5, ENSMUST00000073973.11
    Conserved Domains (2) summary
    pfam01401
    Location:21 → 606
    Peptidase_M2; Angiotensin-converting enzyme
    pfam16959
    Location:617 → 770
    Collectrin; Renal amino acid transporter

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    162922338..162971414
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R0I0.1 GenPept UniProtKB/Swiss-Prot:Q8R0I0

Gene LinkOut

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