U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Slc25a32 solute carrier family 25, member 32 [ Mus musculus (house mouse) ]

Gene ID: 69906, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
Slc25a32provided by MGI
Official Full Name
solute carrier family 25, member 32provided by MGI
Primary source
MGI:MGI:1917156
See related
Ensembl:ENSMUSG00000022299 AllianceGenome:MGI:1917156
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mftc; 2610043O12Rik
Summary
Predicted to enable FAD transmembrane transporter activity and folic acid transmembrane transporter activity. Involved in folate import into mitochondrion. Located in mitochondrion. Is expressed in embryo and metencephalon floor plate. Orthologous to human SLC25A32 (solute carrier family 25 member 32). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 2.4), adrenal adult (RPKM 2.1) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Slc25a32 in Genome Data Viewer
Location:
15 B3.1; 15 15.39 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (38954625..38976213, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (39091230..39112720, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene 7194 Neighboring gene STARR-seq mESC enhancer starr_38471 Neighboring gene collagen triple helix repeat containing 1 Neighboring gene STARR-seq mESC enhancer starr_38472 Neighboring gene STARR-positive B cell enhancer mm9_chr15:38944202-38944502 Neighboring gene DDB1 and CUL4 associated factor 13 Neighboring gene STARR-seq mESC enhancer starr_38473 Neighboring gene STARR-seq mESC enhancer starr_38474 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Formate rescues neural tube defects caused by mutations in Slc25a32. Kim J, et al. Proc Natl Acad Sci U S A, 2018 May 1. PMID 29666258, Free PMC Article
  2. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  3. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (5)  1 citation

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables FAD transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables FAD transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables FAD transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables folic acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables folic acid transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in folate import into mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in folate import into mitochondrion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in folate import into mitochondrion ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial FAD transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrial FAD transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in nucleotide transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
solute carrier family 25 member 32
Names
mitochondrial FAD transporter
mitochondrial folate transporter/carrier

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172402.3 → NP_765990.2  solute carrier family 25 member 32

    See identical proteins and their annotated locations for NP_765990.2

    Status: VALIDATED

    Source sequence(s)
    AK145178, AK167501, BB308144, BB641480
    Consensus CDS
    CCDS27443.1
    UniProtKB/Swiss-Prot
    Q3TCM5, Q8BMG8
    UniProtKB/TrEMBL
    Q8K0B7
    Related
    ENSMUSP00000022908.9, ENSMUST00000022908.10
    Conserved Domains (2) summary
    PTZ00169
    Location:26 → 307
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    pfam00153
    Location:116 → 213
    Mito_carr; Mitochondrial carrier protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    38954625..38976213 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159580.1 → XP_036015473.1  solute carrier family 25 member 32 isoform X3

    UniProtKB/TrEMBL
    Q3T9D8
    Conserved Domains (1) summary
    pfam00153
    Location:116 → 213
    Mito_carr; Mitochondrial carrier protein

  2. XM_006521385.5 → XP_006521448.1  solute carrier family 25 member 32 isoform X2

    UniProtKB/TrEMBL
    Q3T9D8
    Conserved Domains (1) summary
    pfam00153
    Location:118 → 212
    Mito_carr; Mitochondrial carrier protein

  3. XM_036159581.1 → XP_036015474.1  solute carrier family 25 member 32 isoform X4

    UniProtKB/TrEMBL
    Q3T9D8
    Conserved Domains (1) summary
    pfam00153
    Location:23 → 109
    Mito_carr; Mitochondrial carrier protein

  4. XM_036159578.1 → XP_036015471.1  solute carrier family 25 member 32 isoform X1

    UniProtKB/TrEMBL
    Q8K0B7
    Related
    ENSMUSP00000154227.2, ENSMUST00000227323.2
    Conserved Domains (2) summary
    PTZ00169
    Location:26 → 292
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    pfam00153
    Location:206 → 294
    Mito_carr; Mitochondrial carrier protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BMG8.1 GenPept UniProtKB/Swiss-Prot:Q8BMG8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous