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Rnaseh2a ribonuclease H2, large subunit [ Mus musculus (house mouse) ]

Gene ID: 69724, updated on 21-Apr-2024

Summary

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Official Symbol
Rnaseh2aprovided by MGI
Official Full Name
ribonuclease H2, large subunitprovided by MGI
Primary source
MGI:MGI:1916974
See related
Ensembl:ENSMUSG00000052926 AllianceGenome:MGI:1916974
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
RNHL; RNHIA; RNASEHI; 2400006P09Rik
Summary
Predicted to enable RNA-DNA hybrid ribonuclease activity. Acts upstream of or within mismatch repair. Part of ribonuclease H2 complex. Is expressed in several structures, including embryo ectoderm; gut; hemolymphoid system gland; skin; and testis. Human ortholog(s) of this gene implicated in Aicardi-Goutieres syndrome. Orthologous to human RNASEH2A (ribonuclease H2 subunit A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 196.9), liver E14 (RPKM 12.9) and 3 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 C3; 8 41.38 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (85683239..85694498, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (84956610..84969598, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 38426 Neighboring gene microtubule associated serine/threonine kinase 1 Neighboring gene retbindin Neighboring gene STARR-positive B cell enhancer ABC_E6668 Neighboring gene STARR-positive B cell enhancer ABC_E2269 Neighboring gene STARR-seq mESC enhancer starr_22143 Neighboring gene peroxiredoxin 2 Neighboring gene STARR-positive B cell enhancer ABC_E1764 Neighboring gene jun B proto-oncogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. RNaseH2A downregulation drives inflammatory gene expression via genomic DNA fragmentation in senescent and cancer cells. Sugawara S, et al. Commun Biol, 2022 Dec 28. PMID 36577784, Free PMC Article
  2. Functional consequences of the RNase H2A subunit mutations that cause Aicardi-Goutieres syndrome. Coffin SR, et al. J Biol Chem, 2011 May 13. PMID 21454563, Free PMC Article
  3. Aicardi-Goutières syndrome: clues from the RNase H2 knock-out mouse. Rabe B. J Mol Med (Berl), 2013 Nov. PMID 23744109
  4. RNase H2 catalytic core Aicardi-Goutières syndrome-related mutant invokes cGAS-STING innate immune-sensing pathway in mice. Pokatayev V, et al. J Exp Med, 2016 Mar 7. PMID 26880576, Free PMC Article
  5. The structure of the mammalian RNase H2 complex provides insight into RNA.NA hybrid processing to prevent immune dysfunction. Shaban NM, et al. J Biol Chem, 2010 Feb 5. PMID 19923215, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RNaseH2A downregulation drives inflammatory gene expression via genomic DNA fragmentation in senescent and cancer cells.
    Title: RNaseH2A downregulation drives inflammatory gene expression via genomic DNA fragmentation in senescent and cancer cells.
  2. An RNase H2 mutant lacking ribonucleotide excision repair activity but supporting R-loop removal revealed that ribonucleotides in DNA initiate p53-dependent DNA damage response and early embryonic arrest in mouse.
    Title: Two RNase H2 Mutants with Differential rNMP Processing Activity Reveal a Threshold of Ribonucleotide Tolerance for Embryonic Development.
  3. the G37S mutation of RNaseH2 led to increased expression of interferon-stimulated genes dependent on the cGAS-STING signaling pathway.
    Title: RNase H2 catalytic core Aicardi-Goutières syndrome-related mutant invokes cGAS-STING innate immune-sensing pathway in mice.
  4. Recent evidence gathered from ribonuclease H2 knock-out mice provides insight into the molecular mechanisms underlying Aicardi-Goutieres syndrome development and a potential role of DNA damage as a trigger of autoimmunity is discussed. [review]
    Title: Aicardi-Goutières syndrome: clues from the RNase H2 knock-out mouse.
  5. analysis of the RNase H2A subunit mutations that cause Aicardi-Goutieres syndrome
    Title: Functional consequences of the RNase H2A subunit mutations that cause Aicardi-Goutieres syndrome.
  6. Data show that the interwoven architecture of RNase H2B and RNase H2C that interface with RNase H2A in a complex ideally suited for nucleic acid binding and hydrolysis coupled to protein-protein interaction motifs.
    Title: The structure of the mammalian RNase H2 complex provides insight into RNA.NA hybrid processing to prevent immune dysfunction.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (4)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA-DNA hybrid ribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA-DNA hybrid ribonuclease activity ISO
Inferred from Sequence Orthology
more info
  
enables endonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA replication, removal of RNA primer IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in RNA catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in RNA metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in mismatch repair IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within mismatch repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within mismatch repair ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in mismatch repair NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of ribonuclease H2 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ribonuclease H2 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ribonuclease H2 complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of ribonuclease H2 complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ribonuclease H2 subunit A
Names
RNase H2 subunit A
RNase HI large subunit
ribonuclease HI large subunit
ribonuclease HI subunit A
NP_001351299.1
NP_081463.1
XP_011246799.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001364370.2 → NP_001351299.1  ribonuclease H2 subunit A isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC163703
    Consensus CDS
    CCDS90429.1
    UniProtKB/TrEMBL
    F6RP29, Q05C51
    Related
    ENSMUSP00000066769.9, ENSMUST00000065049.15
    Conserved Domains (1) summary
    cd07181
    Location:31 → 251
    RNase_HII_eukaryota_like; Eukaryotic RNase HII

  2. NM_027187.5 → NP_081463.1  ribonuclease H2 subunit A isoform 1

    See identical proteins and their annotated locations for NP_081463.1

    Status: VALIDATED

    Source sequence(s)
    AC163703
    Consensus CDS
    CCDS22486.1
    UniProtKB/Swiss-Prot
    Q8CHY8, Q9CWY8
    UniProtKB/TrEMBL
    F6RP29
    Related
    ENSMUSP00000105360.4, ENSMUST00000109738.10
    Conserved Domains (1) summary
    cd07181
    Location:31 → 251
    RNase_HII_eukaryota_like; Eukaryotic RNase HII

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    85683239..85694498 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011248497.4 → XP_011246799.1  ribonuclease H2 subunit A isoform X1

    See identical proteins and their annotated locations for XP_011246799.1

    UniProtKB/Swiss-Prot
    Q8CHY8, Q9CWY8
    UniProtKB/TrEMBL
    F6RP29
    Related
    ENSMUSP00000120374.2, ENSMUST00000147812.8
    Conserved Domains (1) summary
    cd07181
    Location:31 → 251
    RNase_HII_eukaryota_like; Eukaryotic RNase HII
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CWY8.2 GenPept UniProtKB/Swiss-Prot:Q9CWY8

Gene LinkOut

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