U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Srsf11 serine and arginine-rich splicing factor 11 [ Mus musculus (house mouse) ]

Gene ID: 69207, updated on 3-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Srsf11provided by MGI
Official Full Name
serine and arginine-rich splicing factor 11provided by MGI
Primary source
MGI:MGI:1916457
See related
Ensembl:ENSMUSG00000055436 AllianceGenome:MGI:1916457
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sfrs11; 0610009J05Rik; 2610019N13Rik
Summary
The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]
Expression
Ubiquitous expression in limb E14.5 (RPKM 60.3), CNS E14 (RPKM 43.9) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
3 H4; 3 81.63 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (157716552..157742304, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (158010915..158036667, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1810013D15 gene Neighboring gene STARR-positive B cell enhancer ABC_E2102 Neighboring gene STARR-seq mESC enhancer starr_09387 Neighboring gene STARR-positive B cell enhancer ABC_E7952 Neighboring gene STARR-positive B cell enhancer ABC_E8807 Neighboring gene ankyrin repeat domain 13c Neighboring gene STARR-seq mESC enhancer starr_09389 Neighboring gene STARR-positive B cell enhancer ABC_E2684 Neighboring gene STARR-positive B cell enhancer mm9_chr3:157723907-157724208 Neighboring gene STARR-positive B cell enhancer ABC_E11232 Neighboring gene STARR-positive B cell enhancer ABC_E7953 Neighboring gene leucine rich repeat containing 40 Neighboring gene leucine rich repeat containing 7 Neighboring gene STARR-seq mESC enhancer starr_09391 Neighboring gene STARR-seq mESC enhancer starr_09392

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. SFRS11 Loss Leads to Aging-Associated Cognitive Decline by Modulating LRP8 and ApoE. Raihan O, et al. Cell Rep, 2019 Jul 2. PMID 31269452
  2. Splicing factor TRA2B is required for neural progenitor survival. Roberts JM, et al. J Comp Neurol, 2014 Feb 1. PMID 23818142, Free PMC Article
  3. A genetic analysis of neural progenitor differentiation. Geschwind DH, et al. Neuron, 2001 Feb. PMID 11239426
  4. USP1 deubiquitinates Akt to inhibit PI3K-Akt-FoxO signaling in muscle during prolonged starvation. Goldbraikh D, et al. EMBO Rep, 2020 Apr 3. PMID 32133736, Free PMC Article
  5. Neural progenitor genes. Germinal zone expression and analysis of genetic overlap in stem cell populations. Easterday MC, et al. Dev Biol, 2003 Dec 15. PMID 14651920

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SFRS11 Loss Leads to Aging-Associated Cognitive Decline by Modulating LRP8 and ApoE.
    Title: SFRS11 Loss Leads to Aging-Associated Cognitive Decline by Modulating LRP8 and ApoE.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
serine/arginine-rich splicing factor 11
Names
splicing factor, arginine/serine-rich 11

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001093752.5 → NP_001087221.2  serine/arginine-rich splicing factor 11 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC145301
    Consensus CDS
    CCDS51103.1
    UniProtKB/TrEMBL
    Q3UIX4
    Related
    ENSMUSP00000113685.2, ENSMUST00000121326.8

  2. NM_001093753.3 → NP_001087222.1  serine/arginine-rich splicing factor 11 isoform 1

    See identical proteins and their annotated locations for NP_001087222.1

    Status: REVIEWED

    Source sequence(s)
    AC145301
    Consensus CDS
    CCDS51102.1
    UniProtKB/TrEMBL
    F6RDI8, Q3UIX4
    Related
    ENSMUSP00000072651.9, ENSMUST00000072875.15
    Conserved Domains (1) summary
    cd12518
    Location:27 → 106
    RRM_SRSF11; RNA recognition motif in serine/arginine-rich splicing factor 11 (SRSF11) and similar proteins

  3. NM_001379531.3 → NP_001366460.2  serine/arginine-rich splicing factor 11 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC145301
    Related
    ENSMUSP00000063916.9, ENSMUST00000069025.14

  4. NM_001379532.3 → NP_001366461.2  serine/arginine-rich splicing factor 11 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC145301

  5. NM_001379533.1 → NP_001366462.1  serine/arginine-rich splicing factor 11 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC145301
    UniProtKB/TrEMBL
    F6RDI8
    Conserved Domains (1) summary
    cd12518
    Location:27 → 106
    RRM_SRSF11; RNA recognition motif (RRM) found in serine/arginine-rich splicing factor 11 (SRSF11) and similar proteins

  6. NM_001426772.1 → NP_001413701.1  serine/arginine-rich splicing factor 11 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC145301

  7. NM_001426773.1 → NP_001413702.1  serine/arginine-rich splicing factor 11 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC145301

  8. NM_001426774.1 → NP_001413703.1  serine/arginine-rich splicing factor 11 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC145301
    UniProtKB/TrEMBL
    Q3UIX4

  9. NM_001426775.1 → NP_001413704.1  serine/arginine-rich splicing factor 11 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC145301

  10. NM_001426776.1 → NP_001413705.1  serine/arginine-rich splicing factor 11 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC145301

  11. NM_001426777.1 → NP_001413706.1  serine/arginine-rich splicing factor 11 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC145301

  12. NM_001426778.1 → NP_001413707.1  serine/arginine-rich splicing factor 11 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC145301

RNA

  1. NR_166757.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC145301

  2. NR_166758.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC145301

  3. NR_166759.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC145301

  4. NR_166760.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC145301

  5. NR_166761.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC145301

  6. NR_166762.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC145301

  7. NR_166763.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC145301

  8. NR_166764.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC145301

  9. NR_166765.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC145301

  10. NR_166766.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC145301

  11. NR_190054.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC145301

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    157716552..157742304 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163271.1 → XP_036019164.1  serine/arginine-rich splicing factor 11 isoform X2

    UniProtKB/TrEMBL
    F6RDI8
    Conserved Domains (1) summary
    cd12518
    Location:27 → 106
    RRM_SRSF11; RNA recognition motif (RRM) found in serine/arginine-rich splicing factor 11 (SRSF11) and similar proteins

  2. XM_036163280.1 → XP_036019173.1  serine/arginine-rich splicing factor 11 isoform X8

  3. XM_036163275.1 → XP_036019168.1  serine/arginine-rich splicing factor 11 isoform X3

    UniProtKB/TrEMBL
    B7ZNC5

  4. XM_036163274.1 → XP_036019167.1  serine/arginine-rich splicing factor 11 isoform X3

    UniProtKB/TrEMBL
    B7ZNC5

  5. XM_036163273.1 → XP_036019166.1  serine/arginine-rich splicing factor 11 isoform X3

    UniProtKB/TrEMBL
    B7ZNC5

  6. XM_036163279.1 → XP_036019172.1  serine/arginine-rich splicing factor 11 isoform X7

  7. XM_006502022.3 → XP_006502085.1  serine/arginine-rich splicing factor 11 isoform X7

  8. XM_036163285.1 → XP_036019178.1  serine/arginine-rich splicing factor 11 isoform X9

  9. XM_036163278.1 → XP_036019171.1  serine/arginine-rich splicing factor 11 isoform X7

  10. XM_036163284.1 → XP_036019177.1  serine/arginine-rich splicing factor 11 isoform X9

  11. XM_030252790.2 → XP_030108650.1  serine/arginine-rich splicing factor 11 isoform X3

    UniProtKB/TrEMBL
    B7ZNC5

  12. XM_036163282.1 → XP_036019175.1  serine/arginine-rich splicing factor 11 isoform X8

  13. XM_036163277.1 → XP_036019170.1  serine/arginine-rich splicing factor 11 isoform X7

  14. XM_036163272.1 → XP_036019165.1  serine/arginine-rich splicing factor 11 isoform X3

    UniProtKB/TrEMBL
    B7ZNC5

  15. XM_036163283.1 → XP_036019176.1  serine/arginine-rich splicing factor 11 isoform X9

  16. XM_036163281.1 → XP_036019174.1  serine/arginine-rich splicing factor 11 isoform X8

  17. XM_036163276.1 → XP_036019169.1  serine/arginine-rich splicing factor 11 isoform X7

  18. XM_030252791.2 → XP_030108651.1  serine/arginine-rich splicing factor 11 isoform X5

    UniProtKB/TrEMBL
    B7ZNC5

  19. XM_030252793.2 → XP_030108653.1  serine/arginine-rich splicing factor 11 isoform X4

    UniProtKB/TrEMBL
    B7ZNC5, Q8BV04

  20. XM_030252792.2 → XP_030108652.1  serine/arginine-rich splicing factor 11 isoform X6

    UniProtKB/TrEMBL
    B7ZNC5

RNA

  1. XR_001783740.2 RNA Sequence

  2. XR_375573.4 RNA Sequence

  3. XR_001783741.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001356997.1: Suppressed sequence

    Description
    NM_001356997.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.

  2. NM_026989.3: Suppressed sequence

    Description
    NM_026989.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous