Comtd1 catechol-O-methyltransferase domain containing 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Comtd1provided by MGI
Official Full Name: catechol-O-methyltransferase domain containing 1provided by MGI
Primary source: MGI:MGI:1916406
See related: Ensembl:ENSMUSG00000021773 AllianceGenome:MGI:1916406
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MT773; 1810030M08Rik
Summary: Predicted to enable S-adenosylmethionine-dependent methyltransferase activity. Predicted to act upstream of or within methylation. Located in mitochondrion. Is expressed in alimentary system; liver; and nervous system. Orthologous to human COMTD1 (catechol-O-methyltransferase domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in duodenum adult (RPKM 17.1), stomach adult (RPKM 16.9) and 28 other tissues See more
Orthologs: human all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 14 A3; 14 11.92 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (21895929..21898978, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (21845861..21848910, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A frame-shift mutation in COMTD1 is associated with impaired pheomelanin pigmentation in chicken.
Title: A frame-shift mutation in COMTD1 is associated with impaired pheomelanin pigmentation in chicken.

Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (1)

General gene information

Go to the top of the page Help

Markers

Vdac2 (e-PCR), detects polymorphism
- UniSTS:499191

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables O-methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables S-adenosylmethionine-dependent methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within methylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: catechol O-methyltransferase domain-containing protein 1

Names: O-methyltransferase-containing protein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_026965.2 → NP_081241.1 catechol O-methyltransferase domain-containing protein 1

See identical proteins and their annotated locations for NP_081241.1

Status: PROVISIONAL

Source sequence(s)

AK054334

Consensus CDS

CCDS26868.1

UniProtKB/Swiss-Prot

Q8BIG7

Related

ENSMUSP00000119330.2, ENSMUST00000124549.9

Conserved Domains (1) summary

cl17173
Location:60 → 261

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...