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Zfp467 zinc finger protein 467 [ Mus musculus (house mouse) ]

Gene ID: 68910, updated on 21-Apr-2024

Summary

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Official Symbol
Zfp467provided by MGI
Official Full Name
zinc finger protein 467provided by MGI
Primary source
MGI:MGI:1916160
See related
Ensembl:ENSMUSG00000068551 AllianceGenome:MGI:1916160
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
EZI; Znf467; MNCb-3350; 1190001I08Rik
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within regulation of transcription, DNA-templated. Located in nucleus. Is expressed in cerebellum internal granule cell layer; male reproductive system; and urinary system. Orthologous to human ZNF467 (zinc finger protein 467). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in colon adult (RPKM 24.5), adrenal adult (RPKM 24.5) and 23 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 B2.3; 6 23.39 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (48404626..48422926, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (48427692..48445992, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 16630 Neighboring gene KRAB-A domain containing 1 Neighboring gene STARR-positive B cell enhancer mm9_chr6:48394046-48394347 Neighboring gene predicted gene, 38803 Neighboring gene predicted gene, 57777 Neighboring gene SCO-spondin Neighboring gene zinc finger protein 862, pseudogene Neighboring gene ribosomal protein L35a pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Zinc finger protein 467 regulates Wnt signaling by modulating the expression of sclerostin in adipose derived stem cells. You L, et al. Biochem Biophys Res Commun, 2015 Jan 9. PMID 25490389
  2. Suppression of zinc finger protein 467 alleviates osteoporosis through promoting differentiation of adipose derived stem cells to osteoblasts. You L, et al. J Transl Med, 2012 Jan 17. PMID 22252242, Free PMC Article
  3. The role of Zfp467 in mediating the pro-osteogenic and anti-adipogenic effects on bone and bone marrow niche. Le PT, et al. Bone, 2021 Mar. PMID 33359894, Free PMC Article
  4. Zinc finger protein 467 is a novel regulator of osteoblast and adipocyte commitment. Quach JM, et al. J Biol Chem, 2011 Feb 11. PMID 21123171, Free PMC Article
  5. PTH regulates osteogenesis and suppresses adipogenesis through Zfp467 in a feed-forward, PTH1R-cyclic AMP-dependent manner. Liu H, et al. Elife, 2023 Apr 26. PMID 37159501, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PTH regulates osteogenesis and suppresses adipogenesis through Zfp467 in a feed-forward, PTH1R-cyclic AMP-dependent manner.
    Title: PTH regulates osteogenesis and suppresses adipogenesis through Zfp467 in a feed-forward, PTH1R-cyclic AMP-dependent manner.
  2. these results indicate that Zfp467 regulates the differentiation of adipose-derived stem cells via a mechanism involving Sost-mediated inhibition of Wnt signaling, suggesting potential therapeutic targets for the treatment of osteoporosis.
    Title: Zinc finger protein 467 regulates Wnt signaling by modulating the expression of sclerostin in adipose derived stem cells.
  3. Zfp467 play an important role in adipose derived stem cells differentiation to adipocyte and osteoblast.
    Title: Suppression of zinc finger protein 467 alleviates osteoporosis through promoting differentiation of adipose derived stem cells to osteoblasts.
  4. Zfp467 is a novel co-factor that promotes adipocyte differentiation and suppresses osteoblast differentiation
    Title: Zinc finger protein 467 is a novel regulator of osteoblast and adipocyte commitment.
  5. EZI. EZI is a novel nuclear zinc finger protein that augments STAT3 activity by keeping it in the nucleus.
    Title: A novel nuclear zinc finger protein EZI enhances nuclear retention and transactivation of STAT3.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
zinc finger protein 467
Names
endothelial cell-derived zinc finger protein
zinc finger protein EZI

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001085415.1 → NP_001078884.1  zinc finger protein 467 isoform a

    See identical proteins and their annotated locations for NP_001078884.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has a distinct 5' UTR, compared to variant 1. Both variants 1 and 2 encode the longest isoform (a).
    Source sequence(s)
    AK032551, AK033146, BQ571818, BY661825
    Consensus CDS
    CCDS51764.1
    UniProtKB/Swiss-Prot
    Q8JZL0, Q9JJ98
    UniProtKB/TrEMBL
    B2RU53
    Related
    ENSMUSP00000110207.2, ENSMUST00000114560.8
    Conserved Domains (2) summary
    COG5048
    Location:190 → 564
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:218 → 238
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. NM_001085416.1 → NP_001078885.1  zinc finger protein 467 isoform b

    See identical proteins and their annotated locations for NP_001078885.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has a distinct 5' UTR and uses an alternate splice site, compared to variant 1, that results in a frameshift. The resulting protein (isoform b) has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AK032551, AK033146, BY661825
    Consensus CDS
    CCDS51765.1
    UniProtKB/TrEMBL
    D3Z7M0, G3X9X3
    Related
    ENSMUSP00000110206.2, ENSMUST00000114559.8

  3. NM_001085417.1 → NP_001078886.1  zinc finger protein 467 isoform c

    See identical proteins and their annotated locations for NP_001078886.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate 3' exon, compared to variant 1. The resulting protein (isoform c) has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AI552311, AK140205, BE448817, BQ175111
    Consensus CDS
    CCDS51763.1
    UniProtKB/TrEMBL
    D3Z7L9, Q3USQ2
    Related
    ENSMUSP00000098986.4, ENSMUST00000101443.10

  4. NM_001355746.1 → NP_001342675.1  zinc finger protein 467 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses an alternate splice site, compared to variant 1, that results in a frameshift. The resulting protein (isoform b) has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AC153815, BY661825
    Consensus CDS
    CCDS51765.1
    UniProtKB/TrEMBL
    D3Z7M0, G3X9X3
    Related
    ENSMUSP00000110205.2, ENSMUST00000114558.8

  5. NM_001355747.1 → NP_001342676.1  zinc finger protein 467 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks an internal exon and uses an alternate splice site, compared to variant 1, that results in a frameshift. The resulting protein (isoform d) has a shorter N-terminus and a distinct C-terminus compared to isoform a.
    Source sequence(s)
    AC153815, BY661825
    Consensus CDS
    CCDS90044.1
    UniProtKB/TrEMBL
    D3Z7M1
    Related
    ENSMUSP00000110203.2, ENSMUST00000114556.2

  6. NM_020589.2 → NP_065614.2  zinc finger protein 467 isoform a

    See identical proteins and their annotated locations for NP_065614.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Both variants 1 and 2 encode the longest isoform (a).
    Source sequence(s)
    AI552311, AK032551, AK033146, BE448817, BQ571818, BY661825, CK791410
    Consensus CDS
    CCDS51764.1
    UniProtKB/Swiss-Prot
    Q8JZL0, Q9JJ98
    UniProtKB/TrEMBL
    B2RU53
    Related
    ENSMUSP00000110208.3, ENSMUST00000114561.9
    Conserved Domains (2) summary
    COG5048
    Location:190 → 564
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:218 → 238
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    48404626..48422926 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030255582.1 → XP_030111442.1  zinc finger protein 467 isoform X8

    UniProtKB/TrEMBL
    D3Z7L9, Q3USQ2

  2. XM_006506548.5 → XP_006506611.1  zinc finger protein 467 isoform X6

  3. XM_036152284.1 → XP_036008177.1  zinc finger protein 467 isoform X8

    UniProtKB/TrEMBL
    D3Z7L9, Q3USQ2

  4. XM_006506550.5 → XP_006506613.1  zinc finger protein 467 isoform X8

    See identical proteins and their annotated locations for XP_006506613.1

    UniProtKB/TrEMBL
    D3Z7L9, Q3USQ2
    Related
    ENSMUSP00000110213.2, ENSMUST00000114566.8

  5. XM_006506544.1 → XP_006506607.1  zinc finger protein 467 isoform X1

    See identical proteins and their annotated locations for XP_006506607.1

    Conserved Domains (2) summary
    COG5048
    Location:171 → 545
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:199 → 219
    ZF_C2H2; C2H2 Zn finger [structural motif]

  6. XM_006506547.3 → XP_006506610.1  zinc finger protein 467 isoform X4

    See identical proteins and their annotated locations for XP_006506610.1

    Conserved Domains (4) summary
    COG5048
    Location:68 → 389
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:16 → 36
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:14 → 36
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:28 → 53
    zf-H2C2_2; Zinc-finger double domain

  7. XM_030255581.2 → XP_030111441.1  zinc finger protein 467 isoform X5

    UniProtKB/TrEMBL
    D3Z7M1

  8. XM_030255577.2 → XP_030111437.1  zinc finger protein 467 isoform X1

    Conserved Domains (2) summary
    COG5048
    Location:171 → 545
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:199 → 219
    ZF_C2H2; C2H2 Zn finger [structural motif]

  9. XM_006506549.5 → XP_006506612.1  zinc finger protein 467 isoform X7

  10. XM_011241450.4 → XP_011239752.1  zinc finger protein 467 isoform X2

    Conserved Domains (2) summary
    COG5048
    Location:213 → 587
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:241 → 261
    ZF_C2H2; C2H2 Zn finger [structural motif]

  11. XM_030255579.2 → XP_030111439.1  zinc finger protein 467 isoform X3

    UniProtKB/Swiss-Prot
    Q8JZL0, Q9JJ98
    UniProtKB/TrEMBL
    B2RU53
    Conserved Domains (2) summary
    COG5048
    Location:190 → 564
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:218 → 238
    ZF_C2H2; C2H2 Zn finger [structural motif]

  12. XM_030255578.2 → XP_030111438.1  zinc finger protein 467 isoform X3

    UniProtKB/Swiss-Prot
    Q8JZL0, Q9JJ98
    UniProtKB/TrEMBL
    B2RU53
    Conserved Domains (2) summary
    COG5048
    Location:190 → 564
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:218 → 238
    ZF_C2H2; C2H2 Zn finger [structural motif]

  13. XM_006506545.5 → XP_006506608.1  zinc finger protein 467 isoform X1

    See identical proteins and their annotated locations for XP_006506608.1

    Conserved Domains (2) summary
    COG5048
    Location:171 → 545
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:199 → 219
    ZF_C2H2; C2H2 Zn finger [structural motif]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8JZL0.1 GenPept UniProtKB/Swiss-Prot:Q8JZL0

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