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Abhd13 abhydrolase domain containing 13 [ Mus musculus (house mouse) ]

Gene ID: 68904, updated on 11-Apr-2024

Summary

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Official Symbol
Abhd13provided by MGI
Official Full Name
abhydrolase domain containing 13provided by MGI
Primary source
MGI:MGI:1916154
See related
Ensembl:ENSMUSG00000040396 AllianceGenome:MGI:1916154
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1110065L07Rik
Summary
Enables palmitoyl-(protein) hydrolase activity. Involved in protein depalmitoylation. Located in dendrite cytoplasm. Is expressed in metanephros. Orthologous to human ABHD13 (abhydrolase domain containing 13). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 4.9), placenta adult (RPKM 4.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 A1.1; 8 4.53 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (10027717..10042155)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (9977717..9992155)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene NALCN channel auxiliary factor 1 Neighboring gene STARR-seq mESC enhancer starr_20686 Neighboring gene STARR-seq mESC enhancer starr_20687 Neighboring gene STARR-seq mESC enhancer starr_20688 Neighboring gene STARR-seq mESC enhancer starr_20691 Neighboring gene STARR-seq mESC enhancer starr_20692 Neighboring gene STARR-seq mESC enhancer starr_20693 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:9912234-9912417 Neighboring gene STARR-seq mESC enhancer starr_20694 Neighboring gene STARR-positive B cell enhancer ABC_E8225 Neighboring gene STARR-positive B cell enhancer ABC_E10489 Neighboring gene tumor necrosis factor (ligand) superfamily, member 13b Neighboring gene ligase IV, DNA, ATP-dependent Neighboring gene predicted gene 44788

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A locus for renal malformations including vesico-ureteric reflux on chromosome 13q33-34. Vats KR, et al. J Am Soc Nephrol, 2006 Apr. PMID 16565260
  2. Identification of PSD-95 Depalmitoylating Enzymes. Yokoi N, et al. J Neurosci, 2016 Jun 15. PMID 27307232, Free PMC Article
  3. Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo. Evsikov AV, et al. Genes Dev, 2006 Oct 1. PMID 17015433, Free PMC Article
  4. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
  5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables palmitoyl-(protein) hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables palmitoyl-(protein) hydrolase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein depalmitoylation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in dendrite cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
protein ABHD13
Names
abhydrolase domain-containing protein 13
alpha/beta hydrolase domain-containing protein 13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081119.1 → NP_001074588.1  protein ABHD13

    See identical proteins and their annotated locations for NP_001074588.1

    Status: VALIDATED

    Description
    Transcript Variant: : This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AI553397, AK032495, AK044407, BY742957
    Consensus CDS
    CCDS40217.1
    UniProtKB/Swiss-Prot
    Q80UX8, Q8BXS1, Q9D0V5
    Related
    ENSMUSP00000036730.6, ENSMUST00000048216.6
    Conserved Domains (2) summary
    pfam00561
    Location:115 → 300
    Abhydrolase_1; alpha/beta hydrolase fold
    pfam12695
    Location:116 → 299
    Abhydrolase_5; Alpha/beta hydrolase family

  2. NM_026868.1 → NP_081144.1  protein ABHD13

    See identical proteins and their annotated locations for NP_081144.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AI553397, AK032495, AK044407, BY742957, DV655120
    Consensus CDS
    CCDS40217.1
    UniProtKB/Swiss-Prot
    Q80UX8, Q8BXS1, Q9D0V5
    Related
    ENSMUSP00000116130.2, ENSMUST00000139793.8
    Conserved Domains (2) summary
    pfam00561
    Location:115 → 300
    Abhydrolase_1; alpha/beta hydrolase fold
    pfam12695
    Location:116 → 299
    Abhydrolase_5; Alpha/beta hydrolase family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    10027717..10042155
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80UX8.1 GenPept UniProtKB/Swiss-Prot:Q80UX8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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