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Atp6v1c2 ATPase, H+ transporting, lysosomal V1 subunit C2 [ Mus musculus (house mouse) ]

Gene ID: 68775, updated on 5-Mar-2024

Summary

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Official Symbol
Atp6v1c2provided by MGI
Official Full Name
ATPase, H+ transporting, lysosomal V1 subunit C2provided by MGI
Primary source
MGI:MGI:1916025
See related
Ensembl:ENSMUSG00000020566 AllianceGenome:MGI:1916025
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1110038G14Rik
Summary
Enables proton-transporting ATPase activity, rotational mechanism. Predicted to be involved in positive regulation of Wnt signaling pathway. Predicted to act upstream of or within ion transport. Predicted to be part of vacuolar proton-transporting V-type ATPase, V1 domain. Is expressed in several structures, including alimentary system; metanephros; nervous system; nose; and respiratory system. Orthologous to human ATP6V1C2 (ATPase H+ transporting V1 subunit C2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in lung adult (RPKM 11.4), kidney adult (RPKM 6.5) and 3 other tissues See more
Orthologs
human all
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Genomic context

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Location:
12 A1.1; 12 8.06 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (17334722..17375700, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (17284721..17325386, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_31654 Neighboring gene predicted gene, 36568 Neighboring gene predicted gene 10054 Neighboring gene STARR-seq mESC enhancer starr_31655 Neighboring gene STARR-positive B cell enhancer mm9_chr12:17273043-17273344 Neighboring gene STARR-positive B cell enhancer ABC_E10741 Neighboring gene protein disulfide isomerase associated 6 Neighboring gene STARR-positive B cell enhancer ABC_E7124 Neighboring gene predicted gene, 46336 Neighboring gene nucleolar protein 10 Neighboring gene microRNA 3066

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mouse proton pump ATPase C subunit isoforms (C2-a and C2-b) specifically expressed in kidney and lung. Sun-Wada GH, et al. J Biol Chem, 2003 Nov 7. PMID 12947086
  2. Extra-renal locations of the a4 subunit of H(+)ATPase. Golder ZJ, et al. BMC Cell Biol, 2016 Jul 2. PMID 27368196, Free PMC Article
  3. Molecular architecture underlying fluid absorption by the developing inner ear. Honda K, et al. Elife, 2017 Oct 10. PMID 28994389, Free PMC Article
  4. FGFR2b signalling restricts lineage-flexible alveolar progenitors during mouse lung development and converges in mature alveolar type 2 cells. Jones MR, et al. Cell Mol Life Sci, 2022 Nov 29. PMID 36445537, Free PMC Article
  5. Diversity of mouse proton-translocating ATPase: presence of multiple isoforms of the C, d and G subunits. Sun-Wada GH, et al. Gene, 2003 Jan 2. PMID 12527205

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables proton transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables proton-transporting ATPase activity, rotational mechanism IBA
Inferred from Biological aspect of Ancestor
more info
  
enables proton-transporting ATPase activity, rotational mechanism IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within proton transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of proton-transporting V-type ATPase, V1 domain IEA
Inferred from Electronic Annotation
more info
  
part_of vacuolar proton-transporting V-type ATPase, V1 domain IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
V-type proton ATPase subunit C 2
Names
ATPase, H+ transporting, V1 subunit C
V-ATPase subunit C 2
vacuolar proton pump subunit C 2
NP_001153104.1
NP_598460.1
XP_006515259.1
XP_006515261.1
XP_006515262.1
XP_017170665.1
XP_030102757.1
XP_036013497.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159632.1 → NP_001153104.1  V-type proton ATPase subunit C 2 isoform 1

    See identical proteins and their annotated locations for NP_001153104.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC159815
    Consensus CDS
    CCDS49034.1
    UniProtKB/TrEMBL
    D3Z5W3
    Related
    ENSMUSP00000020884.10, ENSMUST00000020884.16
    Conserved Domains (2) summary
    cd14785
    Location:55 → 75
    V-ATPase_C; 3-helical coiled coil [structural motif]
    pfam03223
    Location:4 → 427
    V-ATPase_C; V-ATPase subunit C

  2. NM_133699.2 → NP_598460.1  V-type proton ATPase subunit C 2 isoform 2

    See identical proteins and their annotated locations for NP_598460.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AC159815
    Consensus CDS
    CCDS25827.1
    UniProtKB/Swiss-Prot
    Q6PHA4, Q99L60
    UniProtKB/TrEMBL
    D3Z5W3
    Related
    ENSMUSP00000093500.6, ENSMUST00000095820.12
    Conserved Domains (2) summary
    cd14785
    Location:55 → 75
    V-ATPase_C; 3-helical coiled coil [structural motif]
    pfam03223
    Location:5 → 417
    V-ATPase_C; V-ATPase subunit C

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    17334722..17375700 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036157604.1 → XP_036013497.1  V-type proton ATPase subunit C 2 isoform X2

    Conserved Domains (2) summary
    cd14785
    Location:55 → 75
    V-ATPase_C; 3-helical coiled coil [structural motif]
    pfam03223
    Location:5 → 381
    V-ATPase_C; V-ATPase subunit C

  2. XM_006515196.4 → XP_006515259.1  V-type proton ATPase subunit C 2 isoform X1

    See identical proteins and their annotated locations for XP_006515259.1

    UniProtKB/TrEMBL
    D3Z5W3
    Conserved Domains (2) summary
    cd14785
    Location:55 → 75
    V-ATPase_C; 3-helical coiled coil [structural motif]
    pfam03223
    Location:4 → 427
    V-ATPase_C; V-ATPase subunit C

  3. XM_006515199.4 → XP_006515262.1  V-type proton ATPase subunit C 2 isoform X3

    UniProtKB/TrEMBL
    D3Z5W3
    Related
    ENSMUSP00000152515.2, ENSMUST00000221129.2
    Conserved Domains (2) summary
    cd14785
    Location:55 → 75
    V-ATPase_C; 3-helical coiled coil [structural motif]
    pfam03223
    Location:5 → 371
    V-ATPase_C; V-ATPase subunit C

  4. XM_006515198.4 → XP_006515261.1  V-type proton ATPase subunit C 2 isoform X2

    Conserved Domains (2) summary
    cd14785
    Location:55 → 75
    V-ATPase_C; 3-helical coiled coil [structural motif]
    pfam03223
    Location:5 → 381
    V-ATPase_C; V-ATPase subunit C

  5. XM_030246897.1 → XP_030102757.1  V-type proton ATPase subunit C 2 isoform X5

    UniProtKB/TrEMBL
    D3Z5W3
    Conserved Domains (2) summary
    cd14785
    Location:60 → 86
    V-ATPase_C; 3-helical coiled coil [structural motif]
    pfam03223
    Location:1 → 311
    V-ATPase_C; V-ATPase subunit C

  6. XM_017315176.1 → XP_017170665.1  V-type proton ATPase subunit C 2 isoform X4

    UniProtKB/TrEMBL
    D3Z5W3
    Conserved Domains (2) summary
    cd14785
    Location:206 → 283
    V-ATPase_C; 3-helical coiled coil [structural motif]
    pfam03223
    Location:59 → 349
    V-ATPase_C; V-ATPase subunit C
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99L60.1 GenPept UniProtKB/Swiss-Prot:Q99L60

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