Trim37 tripartite motif-containing 37 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Trim37provided by MGI
Official Full Name: tripartite motif-containing 37provided by MGI
Primary source: MGI:MGI:2153072
See related: Ensembl:ENSMUSG00000018548 AllianceGenome:MGI:2153072
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MUL; TEF3; 1110032A10Rik; 2810004E07Rik
Summary: The protein encoded by this gene is part of the tripartite-motif containing family (TRIM), which is typified by the RING, B-box type 1, B-box type 2, and coiled-coil region domains. In mouse this protein is proposed to oligomerize through its coiled coil domain and has been reported to be expressed in neural crest-derived tissues as well as in tissues whose development is regulated by mesenchymal-epithelial interactions. In humans, mutations in this gene are associated with mulibrey (muscle-liver-brain-eye) nanism, an autosomal recessive disorder characterized by prenatal onset growth failure, cardiomyopathy and dysmorphic features. [provided by RefSeq, Jan 2013]
Expression: Biased expression in cortex adult (RPKM 34.0), testis adult (RPKM 33.1) and 14 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 C; 11 51.93 cM

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (87017675..87141700)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (87126790..87250874)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Aerobic glycolysis and tumor progression of hepatocellular carcinoma are mediated by ubiquitin of P53 K48-linked regulated by TRIM37.
Title: Aerobic glycolysis and tumor progression of hepatocellular carcinoma are mediated by ubiquitin of P53 K48-linked regulated by TRIM37.
Increased alveolar epithelial TRAF6 via autophagy-dependent TRIM37 degradation mediates particulate matter-induced lung metastasis.
Title: Increased alveolar epithelial TRAF6 via autophagy-dependent TRIM37 degradation mediates particulate matter-induced lung metastasis.
TRIM37 negatively regulates inflammatory responses induced by virus infection via controlling TRAF6 ubiquitination.
Title: TRIM37 negatively regulates inflammatory responses induced by virus infection via controlling TRAF6 ubiquitination.
TRIM37 has a role in apoptosis and IL-1beta release in mouse BV-2 microglia that involves PPARgamma ubiquitination; it is increased in mononuclear leukocytes of intracerebral hemorrhage patients
Title: Tripartite motif containing protein 37 involves in thrombin stimulated BV-2 microglial cell apoptosis and interleukin 1β release.
Trim37 deficiency in mouse lead to infertility, prenatal-onset growth failure, infertility, cardiopathy, risk for tumors, fatty liver, and type 2 diabetes.
Title: Trim37-deficient mice recapitulate several features of the multi-organ disorder Mulibrey nanism.
We here show that the mouse Trim37 gene presents several alternative splice variants, including a testis-specific transcript with an additional 3' exon.
Title: Tissue expression of the mulibrey nanism-associated Trim37 protein in embryonic and adult mouse tissues.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW537030 (e-PCR)
- UniSTS:179241

NoName (e-PCR)
- UniSTS:236689

AU043018 (e-PCR)
- UniSTS:165784

AI848587 (e-PCR)
- UniSTS:165785

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables histone H2AK119 ubiquitin ligase activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables tumor necrosis factor receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables tumor necrosis factor receptor binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin-protein transferase activity	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in aggresome assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of NF-kappaB transcription factor activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of centriole replication	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of centriole replication	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression, epigenetic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gene expression, epigenetic	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of NF-kappaB transcription factor activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in protein autoubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein autoubiquitination	ISO Inferred from Sequence Orthology more info
acts_upstream_of protein import into peroxisome matrix	ISO Inferred from Sequence Orthology more info
involved_in protein monoubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein stabilization	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of ESC/E(Z) complex	ISO Inferred from Sequence Orthology more info
is_active_in aggresome	IBA Inferred from Biological aspect of Ancestor more info
located_in aggresome	ISO Inferred from Sequence Orthology more info
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in peroxisomal membrane	ISO Inferred from Sequence Orthology more info
is_active_in peroxisome	IBA Inferred from Biological aspect of Ancestor more info
located_in peroxisome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase TRIM37

Names: RING-type E3 ubiquitin transferase TRIM37; TRAF encompassing factor 3; tripartite motif-containing protein 37

NP_001349954.1

EC 2.3.2.27

NP_001349955.1

EC 2.3.2.27

NP_001349956.1

EC 2.3.2.27

NP_001349957.1

EC 2.3.2.27

NP_932104.1

EC 2.3.2.27

XP_006534135.1

EC 2.3.2.27

XP_011247512.1

EC 2.3.2.27

XP_011247514.1

EC 2.3.2.27

XP_036012827.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001363025.1 → NP_001349954.1 E3 ubiquitin-protein ligase TRIM37 isoform 1

Status: REVIEWED

Source sequence(s)

AL596130, AL713917, BX000355

Conserved Domains (4) summary

smart00502
Location:132 → 254

BBC; B-Box C-terminal domain

smart00336
Location:91 → 132

BBOX; B-Box-type zinc finger

cd03773
Location:273 → 406

MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...

cd16619
Location:13 → 55

mRING-HC-C4C4_TRIM37_C-VIII; Modified RING finger, HC subclass (C4C4-type), found in tripartite motif-containing protein 37 (TRIM37) and similar proteins
NM_001363026.1 → NP_001349955.1 E3 ubiquitin-protein ligase TRIM37 isoform 3

Status: REVIEWED

Source sequence(s)

AL596130, AL713917, BX000355

Conserved Domains (3) summary

smart00502
Location:117 → 239

BBC; B-Box C-terminal domain

smart00336
Location:76 → 117

BBOX; B-Box-type zinc finger

cd03773
Location:258 → 391

MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...
NM_001363027.1 → NP_001349956.1 E3 ubiquitin-protein ligase TRIM37 isoform 4

Status: REVIEWED

Source sequence(s)

AL596130, AL713917, BX000355

Conserved Domains (4) summary

smart00502
Location:132 → 254

BBC; B-Box C-terminal domain

smart00336
Location:91 → 132

BBOX; B-Box-type zinc finger

cd03773
Location:273 → 406

MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...

cd16619
Location:13 → 55

mRING-HC-C4C4_TRIM37_C-VIII; Modified RING finger, HC subclass (C4C4-type), found in tripartite motif-containing protein 37 (TRIM37) and similar proteins
NM_001363028.1 → NP_001349957.1 E3 ubiquitin-protein ligase TRIM37 isoform 5

Status: REVIEWED

Source sequence(s)

AL596130, AL713917, BX000355

Conserved Domains (4) summary

smart00502
Location:132 → 254

BBC; B-Box C-terminal domain

smart00336
Location:91 → 132

BBOX; B-Box-type zinc finger

cd03773
Location:273 → 406

MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...

cd16619
Location:13 → 55

mRING-HC-C4C4_TRIM37_C-VIII; Modified RING finger, HC subclass (C4C4-type), found in tripartite motif-containing protein 37 (TRIM37) and similar proteins
NM_197987.2 → NP_932104.1 E3 ubiquitin-protein ligase TRIM37 isoform 2

See identical proteins and their annotated locations for NP_932104.1

Status: REVIEWED

Source sequence(s)

AK140822, BC058678, BY457310

Consensus CDS

CCDS25210.1

UniProtKB/Swiss-Prot

Q5SX31, Q6PCX9, Q8CHC5

Related

ENSMUSP00000049057.7, ENSMUST00000041282.13

Conserved Domains (4) summary

smart00502
Location:132 → 254

BBC; B-Box C-terminal domain

cd00162
Location:15 → 58

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

cd03773
Location:273 → 406

MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...

pfam00643
Location:90 → 132

zf-B_box; B-box zinc finger

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

87017675..87141700

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011249212.4 → XP_011247514.1 E3 ubiquitin-protein ligase TRIM37 isoform X2

See identical proteins and their annotated locations for XP_011247514.1

Conserved Domains (4) summary

smart00502
Location:132 → 254

BBC; B-Box C-terminal domain

cd03773
Location:273 → 406

MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...

cd16619
Location:13 → 55

mRING-HC-C4C4_TRIM37_C-VIII; Modified RING finger, HC subclass (C4C4-type), found in tripartite motif-containing protein 37 (TRIM37) and similar proteins

cd19779
Location:93 → 132

Bbox2_TRIM37_C-VIII; B-box-type 2 zinc finger found in tripartite motif-containing protein 37 (TRIM37) and similar proteins
XM_006534072.4 → XP_006534135.1 E3 ubiquitin-protein ligase TRIM37 isoform X2

See identical proteins and their annotated locations for XP_006534135.1

Conserved Domains (4) summary

smart00502
Location:132 → 254

BBC; B-Box C-terminal domain

cd03773
Location:273 → 406

MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...

cd16619
Location:13 → 55

mRING-HC-C4C4_TRIM37_C-VIII; Modified RING finger, HC subclass (C4C4-type), found in tripartite motif-containing protein 37 (TRIM37) and similar proteins

cd19779
Location:93 → 132

Bbox2_TRIM37_C-VIII; B-box-type 2 zinc finger found in tripartite motif-containing protein 37 (TRIM37) and similar proteins
XM_011249210.3 → XP_011247512.1 E3 ubiquitin-protein ligase TRIM37 isoform X1

See identical proteins and their annotated locations for XP_011247512.1

Conserved Domains (3) summary

smart00502
Location:117 → 239

BBC; B-Box C-terminal domain

cd03773
Location:258 → 391

MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...

cd19779
Location:78 → 117

Bbox2_TRIM37_C-VIII; B-box-type 2 zinc finger found in tripartite motif-containing protein 37 (TRIM37) and similar proteins
XM_036156934.1 → XP_036012827.1 E3 ubiquitin-protein ligase TRIM37 isoform X3

Conserved Domains (3) summary

smart00502
Location:117 → 239

BBC; B-Box C-terminal domain

cd03773
Location:258 → 391

MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...

cd19779
Location:78 → 117

Bbox2_TRIM37_C-VIII; B-box-type 2 zinc finger found in tripartite motif-containing protein 37 (TRIM37) and similar proteins