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Arl8a ADP-ribosylation factor-like 8A [ Mus musculus (house mouse) ]

Gene ID: 68724, updated on 5-Mar-2024

Summary

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Official Symbol
Arl8aprovided by MGI
Official Full Name
ADP-ribosylation factor-like 8Aprovided by MGI
Primary source
MGI:MGI:1915974
See related
Ensembl:ENSMUSG00000026426 AllianceGenome:MGI:1915974
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
gie2; Arl10b; 1110033P22Rik
Summary
Predicted to enable GTP binding activity. Involved in anterograde axonal transport. Predicted to be located in cytoplasm; midbody; and spindle midzone. Predicted to be active in lysosomal membrane. Is expressed in ganglia; sensory organ; and submandibular gland primordium. Orthologous to human ARL8A (ADP ribosylation factor like GTPase 8A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 133.7), whole brain E14.5 (RPKM 99.2) and 25 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1; 1 E4
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (135074572..135084007)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (135146834..135156268)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene leucine-rich repeat-containing G protein-coupled receptor 6 Neighboring gene STARR-seq mESC enhancer starr_02346 Neighboring gene STARR-seq mESC enhancer starr_02347 Neighboring gene protein tyrosine phosphatase receptor type V Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:137029652-137029867 Neighboring gene STARR-positive B cell enhancer ABC_E9480 Neighboring gene protein tyrosine phosphatase, non-receptor type 7 Neighboring gene G protein-coupled receptor 37-like 1 Neighboring gene STARR-seq mESC enhancer starr_02353 Neighboring gene STARR-seq mESC enhancer starr_02355 Neighboring gene predicted gene, 41955

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Novel small GTPase subfamily capable of associating with tubulin is required for chromosome segregation. Okai T, et al. J Cell Sci, 2004 Sep 15. PMID 15331635
  2. Presynaptic Biogenesis Requires Axonal Transport of Lysosome-Related Vesicles. Vukoja A, et al. Neuron, 2018 Sep 19. PMID 30174114
  3. Viral Infection-Induced Differential Expression of LncRNAs Associated with Collagen in Mouse Placentas and Amniotic Sacs. Pan J, et al. Am J Reprod Immunol, 2015 Sep. PMID 26073538
  4. Vti1b promotes TRPV1 sensitization during inflammatory pain. Sondermann JR, et al. Pain, 2019 Feb. PMID 30335684
  5. RNA binding proteins co-localize with small tau inclusions in tauopathy. Maziuk BF, et al. Acta Neuropathol Commun, 2018 Aug 1. PMID 30068389, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding ISO
Inferred from Sequence Orthology
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in anterograde axonal transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in anterograde axonal transport IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within chromosome segregation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in lysosomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lysosome IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in midbody ISO
Inferred from Sequence Orthology
more info
  
located_in spindle midzone ISO
Inferred from Sequence Orthology
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ADP-ribosylation factor-like protein 8A
Names
ADP-ribosylation factor-like 10B
ADP-ribosylation factor-like protein 10B
novel small G protein indispensable for equal chromosome segregation 2
small G protein indispensable for equal chromosome segregation 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026823.2 → NP_081099.1  ADP-ribosylation factor-like protein 8A

    See identical proteins and their annotated locations for NP_081099.1

    Status: PROVISIONAL

    Source sequence(s)
    AC133097
    Consensus CDS
    CCDS15316.1
    UniProtKB/Swiss-Prot
    Q8VEH3, Q99KS1, Q9CTB0
    UniProtKB/TrEMBL
    Q9DAB3
    Related
    ENSMUSP00000027684.5, ENSMUST00000027684.11
    Conserved Domains (1) summary
    cd04159
    Location:22 → 180
    Arl10_like; Arf-like 9 (Arl9) and 10 (Arl10) GTPases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    135074572..135084007
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036153366.1 → XP_036009259.1  ADP-ribosylation factor-like protein 8A isoform X1

    UniProtKB/TrEMBL
    F6QKK2
    Related
    ENSMUSP00000121545.2, ENSMUST00000125774.2
    Conserved Domains (1) summary
    cd04159
    Location:1 → 132
    Arl10_like; Arf-like 9 (Arl9) and 10 (Arl10) GTPases
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VEH3.1 GenPept UniProtKB/Swiss-Prot:Q8VEH3

Gene LinkOut

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