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Rmnd5a required for meiotic nuclear division 5 homolog A [ Mus musculus (house mouse) ]

Gene ID: 68477, updated on 11-Apr-2024

Summary

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Official Symbol
Rmnd5aprovided by MGI
Official Full Name
required for meiotic nuclear division 5 homolog Aprovided by MGI
Primary source
MGI:MGI:1915727
See related
Ensembl:ENSMUSG00000002222 AllianceGenome:MGI:1915727
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gid2; MTA.D02.090; 1110007A06Rik
Summary
Predicted to enable metal ion binding activity and ubiquitin protein ligase activity. Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in nucleoplasm. Predicted to be part of GID complex and ubiquitin ligase complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human RMND5A (required for meiotic nuclear division 5 homolog A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 62.2), cerebellum adult (RPKM 22.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Rmnd5a in Genome Data Viewer
Location:
6 C1; 6 32.14 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (71365623..71417491, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (71388634..71440637, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene CD8 subunit beta 1 Neighboring gene Cd8 alpha DNase I hypersensitive cluster CIV Neighboring gene Cd8 alpha DNase I hypersensitive cluster CIII Neighboring gene Cd8 alpha DNase I hypersensitive cluster CII Neighboring gene CD8 subunit alpha Neighboring gene STARR-seq mESC enhancer starr_16262 Neighboring gene STARR-positive B cell enhancer ABC_E343 Neighboring gene predicted gene, 30582 Neighboring gene STARR-positive B cell enhancer ABC_E10384 Neighboring gene ring finger protein 103

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Differential gene expression in CD3epsilon- and RAG1-deficient thymuses: definition of a set of genes potentially involved in thymocyte maturation. Carrier A, et al. Immunogenetics, 1999 Dec. PMID 10630289
  2. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
  3. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC59617

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of GID complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase RMND5A
Names
protein RMD5 homolog A
NP_001342674.1
NP_077250.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355745.2 → NP_001342674.1  E3 ubiquitin-protein ligase RMND5A

    Status: VALIDATED

    Source sequence(s)
    AC154001, AC160090
    Consensus CDS
    CCDS20231.1
    UniProtKB/Swiss-Prot
    E9QNK7, Q3TPH1, Q3UFE2, Q80YQ8
    Conserved Domains (2) summary
    COG5109
    Location:17 → 391
    COG5109; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    pfam10607
    Location:153 → 297
    CLTH; CTLH/CRA C-terminal to LisH motif domain

  2. NM_024288.3 → NP_077250.2  E3 ubiquitin-protein ligase RMND5A

    See identical proteins and their annotated locations for NP_077250.2

    Status: VALIDATED

    Source sequence(s)
    AC154001, AC160090
    Consensus CDS
    CCDS20231.1
    UniProtKB/Swiss-Prot
    E9QNK7, Q3TPH1, Q3UFE2, Q80YQ8
    Related
    ENSMUSP00000002292.9, ENSMUST00000002292.15
    Conserved Domains (2) summary
    COG5109
    Location:17 → 391
    COG5109; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    pfam10607
    Location:153 → 297
    CLTH; CTLH/CRA C-terminal to LisH motif domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    71365623..71417491 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80YQ8.2 GenPept UniProtKB/Swiss-Prot:Q80YQ8

Gene LinkOut

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