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Fbxl15 F-box and leucine-rich repeat protein 15 [ Mus musculus (house mouse) ]

Gene ID: 68431, updated on 5-Mar-2024

Summary

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Official Symbol
Fbxl15provided by MGI
Official Full Name
F-box and leucine-rich repeat protein 15provided by MGI
Primary source
MGI:MGI:1915681
See related
Ensembl:ENSMUSG00000025226 AllianceGenome:MGI:1915681
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fbxo37; 0710008C12Rik
Summary
Predicted to be involved in several processes, including bone mineralization; cellular protein metabolic process; and positive regulation of BMP signaling pathway. Predicted to be located in cytoplasm. Predicted to be part of SCF ubiquitin ligase complex. Is expressed in several structures, including craniocervical region bone; dorsal root ganglion; submandibular gland primordium; ventral grey horn; and vibrissa. Orthologous to human FBXL15 (F-box and leucine rich repeat protein 15). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in duodenum adult (RPKM 21.3), adrenal adult (RPKM 18.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
19 C3; 19 38.81 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (46316623..46318885)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (46328184..46330446)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100 Neighboring gene RIKEN cDNA 4833438C02 gene Neighboring gene STARR-positive B cell enhancer ABC_E9457 Neighboring gene pleckstrin and Sec7 domain containing Neighboring gene CUE domain containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E973 Neighboring gene predicted gene, 36493 Neighboring gene microRNA 146b Neighboring gene RIKEN cDNA 2310034G01 gene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Systematic analysis and nomenclature of mammalian F-box proteins. Jin J, et al. Genes Dev, 2004 Nov 1. PMID 15520277, Free PMC Article
  2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  3. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in G2/M transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in bone mineralization ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SCF ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
F-box/LRR-repeat protein 15
Names
F-box only protein 37

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001378773.1 → NP_001365702.1  F-box/LRR-repeat protein 15 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC114539
    Conserved Domains (3) summary
    cd09293
    Location:175 → 304
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:125 → 151
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam00646
    Location:18 → 55
    F-box; F-box domain

  2. NM_133694.2 → NP_598455.2  F-box/LRR-repeat protein 15 isoform 1

    See identical proteins and their annotated locations for NP_598455.2

    Status: VALIDATED

    Source sequence(s)
    AI594908, AW124512, AW825726, CK791452
    Consensus CDS
    CCDS38007.1
    UniProtKB/Swiss-Prot
    Q3T9R4, Q91W61
    Related
    ENSMUSP00000026256.3, ENSMUST00000026256.9
    Conserved Domains (3) summary
    cd09293
    Location:139 → 268
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:62 → 88
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam00646
    Location:18 → 55
    F-box; F-box domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    46316623..46318885
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161678.1 → XP_036017571.1  F-box/LRR-repeat protein 15 isoform X1

    UniProtKB/Swiss-Prot
    Q3T9R4, Q91W61
    Related
    ENSMUSP00000137489.2, ENSMUST00000177667.2
    Conserved Domains (3) summary
    cd09293
    Location:139 → 268
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:62 → 88
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam00646
    Location:18 → 55
    F-box; F-box domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91W61.2 GenPept UniProtKB/Swiss-Prot:Q91W61

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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