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Ciz1 CDKN1A interacting zinc finger protein 1 [ Mus musculus (house mouse) ]

Gene ID: 68379, updated on 21-Apr-2024

Summary

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Official Symbol
Ciz1provided by MGI
Official Full Name
CDKN1A interacting zinc finger protein 1provided by MGI
Primary source
MGI:MGI:1920234
See related
Ensembl:ENSMUSG00000039205 AllianceGenome:MGI:1920234
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
LSFR1; ZNF356; 0610038H21Rik; 2900056O04Rik
Summary
Enables cyclin binding activity. Acts upstream of or within maintenance of protein location in nucleus and positive regulation of DNA-dependent DNA replication initiation. Located in nucleus. Is expressed in several structures, including brain; genitourinary system; gut; heart; and immune system. Orthologous to human CIZ1 (CDKN1A interacting zinc finger protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 44.2), testis adult (RPKM 35.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 B; 2 22.09 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (32252724..32268311)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (32363007..32378313)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 52590 Neighboring gene predicted gene, 39787 Neighboring gene bublin coiled coil protein Neighboring gene lipocalin 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Prion-like domains drive CIZ1 assembly formation at the inactive X chromosome. Sofi S, et al. J Cell Biol, 2022 Apr 4. PMID 35289833, Free PMC Article
  2. Maintenance of epigenetic landscape requires CIZ1 and is corrupted in differentiated fibroblasts in long-term culture. Stewart ER, et al. Nat Commun, 2019 Jan 28. PMID 30692537, Free PMC Article
  3. DNA damage and neurodegenerative phenotypes in aged Ciz1 null mice. Khan MM, et al. Neurobiol Aging, 2018 Feb. PMID 29154038, Free PMC Article
  4. Cardiomyocyte--specific expression of the nuclear matrix protein, CIZ1, stimulates production of mono-nucleated cells with an extended window of proliferation in the postnatal mouse heart. Bageghni SA, et al. Biol Open, 2017 Jan 15. PMID 27934662, Free PMC Article
  5. Ciz1 promotes tumorigenicity of prostate carcinoma cells. Liu T, et al. Front Biosci (Landmark Ed), 2015 Jan 1. PMID 25553473

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Epigenetic instability caused by absence of CIZ1 drives transformation during quiescence cycles.
    Title: Epigenetic instability caused by absence of CIZ1 drives transformation during quiescence cycles.
  2. Prion-like domains drive CIZ1 assembly formation at the inactive X chromosome.
    Title: Prion-like domains drive CIZ1 assembly formation at the inactive X chromosome.
  3. Time-resolved structured illumination microscopy reveals key principles of Xist RNA spreading.
    Title: Time-resolved structured illumination microscopy reveals key principles of Xist RNA spreading.
  4. CDKN1A interacting zinc finger protein 1 (Ciz1) knockout mice (Ciz1(DeltaE5/DeltaE5) ) lose residues encoded by exon 5 but may gain function from novel amino acid sequences.
    Title: Consequences of Cre-mediated deletion of Ciz1 exon 5 in mice.
  5. It plays a critical role in DNA replication and cell-cycle progression at the G1/S checkpoint.
    Title: DNA damage and neurodegenerative phenotypes in aged Ciz1 null mice.
  6. CIZ1 is recruited to Xi in response to expression of X inactive-specific transcript (Xist) RNA during the earliest stages of X inactivation in embryonic stem cells and is dependent on the C-terminal nuclear matrix anchor domain of CIZ1 and the E repeats of Xist CIZ1-null mice, although viable, display fully penetrant female-specific lymphoproliferative disorder.
    Title: The nuclear matrix protein CIZ1 facilitates localization of Xist RNA to the inactive X-chromosome territory.
  7. This study demonstrated that CIZ1 may be involved in the post-mitotic differentiation of neurons in response to external signals and changes in gene expression may compensate.
    Title: Motor phenotypes and molecular networks associated with germline deficiency of Ciz1.
  8. CIZ1 is a kinase sensor that promotes initiation of DNA replication at low kinase levels, when in a hypophosphorylated state that is permissive for cyclin-A-CDK2 interaction and delivery to licensed origins.
    Title: Cyclin-A-CDK2-mediated phosphorylation of CIZ1 blocks replisome formation and initiation of mammalian DNA replication.
  9. results suggest that CIZ1 may play an important role in the progression of human prostate carcinoma and us which may be used as a therapeutic target in prostate cancer
    Title: Ciz1 promotes tumorigenicity of prostate carcinoma cells.
  10. CIZ1 functions as a tumor suppressor in vivo.
    Title: CIZ1, a p21Cip1/Waf1-interacting protein, functions as a tumor suppressor in vivo.
Submit: New GeneRIF Correction See all GeneRIFs (15)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cyclin binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within maintenance of protein location in nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of DNA-templated DNA replication initiation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of DNA-templated DNA replication initiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cip1-interacting zinc finger protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252534.2 → NP_001239463.1  cip1-interacting zinc finger protein isoform 2

    See identical proteins and their annotated locations for NP_001239463.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate splice site in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AL808027
    UniProtKB/TrEMBL
    Q3TMV1, Q3TXU6
    Conserved Domains (5) summary
    smart00451
    Location:701 → 734
    ZnF_U1; U1-like zinc finger
    PHA03247
    Location:103 → 375
    PHA03247; large tegument protein UL36; Provisional
    sd00020
    Location:555 → 575
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12171
    Location:585 → 609
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
    cl15257
    Location:554 → 621
    GIY-YIG_SF; GIY-YIG nuclease domain superfamily

  2. NM_001252536.2 → NP_001239465.1  cip1-interacting zinc finger protein isoform 3

    See identical proteins and their annotated locations for NP_001239465.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate splice site in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AL808027
    UniProtKB/TrEMBL
    Q3TMV1
    Conserved Domains (5) summary
    smart00451
    Location:697 → 730
    ZnF_U1; U1-like zinc finger
    PHA03247
    Location:46 → 418
    PHA03247; large tegument protein UL36; Provisional
    sd00020
    Location:551 → 571
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12171
    Location:581 → 605
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
    cl15257
    Location:550 → 617
    GIY-YIG_SF; GIY-YIG nuclease domain superfamily

  3. NM_001252537.2 → NP_001239466.1  cip1-interacting zinc finger protein isoform 4

    See identical proteins and their annotated locations for NP_001239466.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and uses two alternate splice sites in the coding region, but maintains the reading frame, compared to variant 1. Variants 4 and 5 encode the same isoform (4), which is shorter than isoform 1.
    Source sequence(s)
    AL808027
    Consensus CDS
    CCDS57166.1
    UniProtKB/TrEMBL
    Q3TMV1, Q3UUV0
    Related
    ENSMUSP00000108958.2, ENSMUST00000113332.8
    Conserved Domains (5) summary
    smart00451
    Location:692 → 725
    ZnF_U1; U1-like zinc finger
    PHA03247
    Location:46 → 413
    PHA03247; large tegument protein UL36; Provisional
    sd00020
    Location:546 → 566
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12171
    Location:576 → 600
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
    cl15257
    Location:545 → 612
    GIY-YIG_SF; GIY-YIG nuclease domain superfamily

  4. NM_001252538.2 → NP_001239467.1  cip1-interacting zinc finger protein isoform 4

    See identical proteins and their annotated locations for NP_001239467.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and uses two alternate splice sites in the coding region, but maintains the reading frame, compared to variant 1. Variants 4 and 5 encode the same isoform (4), which is shorter than isoform 1.
    Source sequence(s)
    AL808027
    Consensus CDS
    CCDS57166.1
    UniProtKB/TrEMBL
    Q3TMV1, Q3UUV0
    Conserved Domains (5) summary
    smart00451
    Location:692 → 725
    ZnF_U1; U1-like zinc finger
    PHA03247
    Location:46 → 413
    PHA03247; large tegument protein UL36; Provisional
    sd00020
    Location:546 → 566
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12171
    Location:576 → 600
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
    cl15257
    Location:545 → 612
    GIY-YIG_SF; GIY-YIG nuclease domain superfamily

  5. NM_028412.3 → NP_082688.1  cip1-interacting zinc finger protein isoform 1

    See identical proteins and their annotated locations for NP_082688.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AL808027
    Consensus CDS
    CCDS15911.1
    UniProtKB/TrEMBL
    Q3TMV1, Q8VEH2
    Related
    ENSMUSP00000048428.8, ENSMUST00000048964.14
    Conserved Domains (6) summary
    smart00451
    Location:746 → 779
    ZnF_U1; U1-like zinc finger
    PHA03247
    Location:46 → 467
    PHA03247; large tegument protein UL36; Provisional
    PRK10263
    Location:272 → 461
    PRK10263; DNA translocase FtsK; Provisional
    sd00020
    Location:600 → 620
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12171
    Location:630 → 654
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
    cl15257
    Location:599 → 666
    GIY-YIG_SF; GIY-YIG nuclease domain superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    32252724..32268311
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006498271.5 → XP_006498334.1  cip1-interacting zinc finger protein isoform X1

    See identical proteins and their annotated locations for XP_006498334.1

    UniProtKB/TrEMBL
    Q3TMV1
    Conserved Domains (6) summary
    smart00451
    Location:767 → 800
    ZnF_U1; U1-like zinc finger
    PRK10263
    Location:293 → 482
    PRK10263; DNA translocase FtsK; Provisional
    sd00020
    Location:621 → 641
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam03154
    Location:133 → 555
    Atrophin-1; Atrophin-1 family
    pfam12171
    Location:651 → 675
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
    cl15257
    Location:620 → 687
    GIY-YIG_SF; GIY-YIG nuclease domain superfamily

  2. XM_006498279.5 → XP_006498342.1  cip1-interacting zinc finger protein isoform X7

    UniProtKB/TrEMBL
    Q3TMV1
    Conserved Domains (5) summary
    smart00451
    Location:722 → 755
    ZnF_U1; U1-like zinc finger
    PHA03247
    Location:103 → 396
    PHA03247; large tegument protein UL36; Provisional
    sd00020
    Location:576 → 596
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12171
    Location:606 → 630
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
    cl15257
    Location:575 → 642
    GIY-YIG_SF; GIY-YIG nuclease domain superfamily

  3. XM_006498280.5 → XP_006498343.1  cip1-interacting zinc finger protein isoform X8

    UniProtKB/TrEMBL
    Q3TMV1
    Conserved Domains (5) summary
    smart00451
    Location:718 → 751
    ZnF_U1; U1-like zinc finger
    PHA03247
    Location:103 → 392
    PHA03247; large tegument protein UL36; Provisional
    sd00020
    Location:572 → 592
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12171
    Location:602 → 626
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
    cl15257
    Location:571 → 638
    GIY-YIG_SF; GIY-YIG nuclease domain superfamily

  4. XM_006498275.5 → XP_006498338.1  cip1-interacting zinc finger protein isoform X3

    See identical proteins and their annotated locations for XP_006498338.1

    UniProtKB/TrEMBL
    Q3TMV1, Q8VEH2
    Related
    ENSMUSP00000108964.3, ENSMUST00000113338.9
    Conserved Domains (6) summary
    smart00451
    Location:746 → 779
    ZnF_U1; U1-like zinc finger
    PHA03247
    Location:46 → 467
    PHA03247; large tegument protein UL36; Provisional
    PRK10263
    Location:272 → 461
    PRK10263; DNA translocase FtsK; Provisional
    sd00020
    Location:600 → 620
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12171
    Location:630 → 654
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
    cl15257
    Location:599 → 666
    GIY-YIG_SF; GIY-YIG nuclease domain superfamily

  5. XM_006498282.5 → XP_006498345.1  cip1-interacting zinc finger protein isoform X10

    See identical proteins and their annotated locations for XP_006498345.1

    UniProtKB/TrEMBL
    Q3TMV1, Q3TXU6
    Conserved Domains (5) summary
    smart00451
    Location:701 → 734
    ZnF_U1; U1-like zinc finger
    PHA03247
    Location:103 → 375
    PHA03247; large tegument protein UL36; Provisional
    sd00020
    Location:555 → 575
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12171
    Location:585 → 609
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
    cl15257
    Location:554 → 621
    GIY-YIG_SF; GIY-YIG nuclease domain superfamily

  6. XM_006498283.5 → XP_006498346.1  cip1-interacting zinc finger protein isoform X11

    See identical proteins and their annotated locations for XP_006498346.1

    UniProtKB/TrEMBL
    Q3TMV1
    Conserved Domains (5) summary
    smart00451
    Location:697 → 730
    ZnF_U1; U1-like zinc finger
    PHA03247
    Location:46 → 418
    PHA03247; large tegument protein UL36; Provisional
    sd00020
    Location:551 → 571
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12171
    Location:581 → 605
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
    cl15257
    Location:550 → 617
    GIY-YIG_SF; GIY-YIG nuclease domain superfamily

  7. XM_006498274.5 → XP_006498337.1  cip1-interacting zinc finger protein isoform X2

    UniProtKB/TrEMBL
    Q3TMV1
    Conserved Domains (6) summary
    smart00451
    Location:762 → 795
    ZnF_U1; U1-like zinc finger
    PHA03247
    Location:46 → 483
    PHA03247; large tegument protein UL36; Provisional
    PRK10263
    Location:288 → 477
    PRK10263; DNA translocase FtsK; Provisional
    sd00020
    Location:616 → 636
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12171
    Location:646 → 670
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
    cl15257
    Location:615 → 682
    GIY-YIG_SF; GIY-YIG nuclease domain superfamily

  8. XM_006498277.5 → XP_006498340.1  cip1-interacting zinc finger protein isoform X5

    UniProtKB/TrEMBL
    Q3TMV1
    Conserved Domains (5) summary
    smart00451
    Location:741 → 774
    ZnF_U1; U1-like zinc finger
    PHA03247
    Location:46 → 462
    PHA03247; large tegument protein UL36; Provisional
    sd00020
    Location:595 → 615
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12171
    Location:625 → 649
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
    cl15257
    Location:594 → 661
    GIY-YIG_SF; GIY-YIG nuclease domain superfamily

  9. XM_030252020.2 → XP_030107880.1  cip1-interacting zinc finger protein isoform X12

    UniProtKB/TrEMBL
    Q3TMV1
    Conserved Domains (5) summary
    smart00451
    Location:696 → 729
    ZnF_U1; U1-like zinc finger
    PHA03247
    Location:103 → 370
    PHA03247; large tegument protein UL36; Provisional
    sd00020
    Location:550 → 570
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12171
    Location:580 → 604
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
    cl15257
    Location:549 → 616
    GIY-YIG_SF; GIY-YIG nuclease domain superfamily

  10. XM_006498276.5 → XP_006498339.1  cip1-interacting zinc finger protein isoform X4

    UniProtKB/TrEMBL
    Q3TMV1
    Conserved Domains (6) summary
    smart00451
    Location:743 → 776
    ZnF_U1; U1-like zinc finger
    PRK10263
    Location:269 → 458
    PRK10263; DNA translocase FtsK; Provisional
    sd00020
    Location:597 → 617
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam03154
    Location:109 → 531
    Atrophin-1; Atrophin-1 family
    pfam12171
    Location:627 → 651
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
    cl15257
    Location:596 → 663
    GIY-YIG_SF; GIY-YIG nuclease domain superfamily

  11. XM_006498278.5 → XP_006498341.1  cip1-interacting zinc finger protein isoform X6

    See identical proteins and their annotated locations for XP_006498341.1

    UniProtKB/TrEMBL
    A2AN61, Q3TMV1
    Related
    ENSMUSP00000108957.2, ENSMUST00000113331.8
    Conserved Domains (6) summary
    smart00451
    Location:722 → 755
    ZnF_U1; U1-like zinc finger
    PRK10263
    Location:248 → 437
    PRK10263; DNA translocase FtsK; Provisional
    sd00020
    Location:576 → 596
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam03154
    Location:130 → 510
    Atrophin-1; Atrophin-1 family
    pfam12171
    Location:606 → 630
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
    cl15257
    Location:575 → 642
    GIY-YIG_SF; GIY-YIG nuclease domain superfamily

  12. XM_006498281.5 → XP_006498344.1  cip1-interacting zinc finger protein isoform X9

    UniProtKB/TrEMBL
    Q3TMV1
    Conserved Domains (5) summary
    smart00451
    Location:717 → 750
    ZnF_U1; U1-like zinc finger
    PHA03247
    Location:111 → 438
    PHA03247; large tegument protein UL36; Provisional
    sd00020
    Location:571 → 591
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12171
    Location:601 → 625
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
    cl15257
    Location:570 → 637
    GIY-YIG_SF; GIY-YIG nuclease domain superfamily

  13. XM_036162520.1 → XP_036018413.1  cip1-interacting zinc finger protein isoform X14

    UniProtKB/TrEMBL
    Q70KX6
    Conserved Domains (6) summary
    smart00451
    Location:666 → 699
    ZnF_U1; U1-like zinc finger
    PHA03247
    Location:16 → 340
    PHA03247; large tegument protein UL36; Provisional
    PRK10263
    Location:192 → 381
    PRK10263; DNA translocase FtsK; Provisional
    sd00020
    Location:520 → 540
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12171
    Location:550 → 574
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
    cl15257
    Location:519 → 586
    GIY-YIG_SF; GIY-YIG nuclease domain superfamily

  14. XM_030252025.2 → XP_030107885.1  cip1-interacting zinc finger protein isoform X18

    UniProtKB/TrEMBL
    Q70KX6
    Conserved Domains (5) summary
    smart00451
    Location:600 → 633
    ZnF_U1; U1-like zinc finger
    PHA03247
    Location:2 → 274
    PHA03247; large tegument protein UL36; Provisional
    sd00020
    Location:454 → 474
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12171
    Location:484 → 508
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
    cl15257
    Location:453 → 520
    GIY-YIG_SF; GIY-YIG nuclease domain superfamily

  15. XM_030252016.2 → XP_030107876.1  cip1-interacting zinc finger protein isoform X2

    UniProtKB/TrEMBL
    Q3TMV1
    Conserved Domains (6) summary
    smart00451
    Location:762 → 795
    ZnF_U1; U1-like zinc finger
    PHA03247
    Location:46 → 483
    PHA03247; large tegument protein UL36; Provisional
    PRK10263
    Location:288 → 477
    PRK10263; DNA translocase FtsK; Provisional
    sd00020
    Location:616 → 636
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12171
    Location:646 → 670
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
    cl15257
    Location:615 → 682
    GIY-YIG_SF; GIY-YIG nuclease domain superfamily

  16. XM_006498273.5 → XP_006498336.1  cip1-interacting zinc finger protein isoform X1

    See identical proteins and their annotated locations for XP_006498336.1

    UniProtKB/TrEMBL
    Q3TMV1
    Conserved Domains (6) summary
    smart00451
    Location:767 → 800
    ZnF_U1; U1-like zinc finger
    PRK10263
    Location:293 → 482
    PRK10263; DNA translocase FtsK; Provisional
    sd00020
    Location:621 → 641
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam03154
    Location:133 → 555
    Atrophin-1; Atrophin-1 family
    pfam12171
    Location:651 → 675
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
    cl15257
    Location:620 → 687
    GIY-YIG_SF; GIY-YIG nuclease domain superfamily

  17. XM_006498272.5 → XP_006498335.1  cip1-interacting zinc finger protein isoform X1

    See identical proteins and their annotated locations for XP_006498335.1

    UniProtKB/TrEMBL
    Q3TMV1
    Conserved Domains (6) summary
    smart00451
    Location:767 → 800
    ZnF_U1; U1-like zinc finger
    PRK10263
    Location:293 → 482
    PRK10263; DNA translocase FtsK; Provisional
    sd00020
    Location:621 → 641
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam03154
    Location:133 → 555
    Atrophin-1; Atrophin-1 family
    pfam12171
    Location:651 → 675
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
    cl15257
    Location:620 → 687
    GIY-YIG_SF; GIY-YIG nuclease domain superfamily

  18. XM_030252023.2 → XP_030107883.1  cip1-interacting zinc finger protein isoform X15

    UniProtKB/TrEMBL
    Q70KX6
    Conserved Domains (6) summary
    smart00451
    Location:645 → 678
    ZnF_U1; U1-like zinc finger
    PHA03247
    Location:16 → 319
    PHA03247; large tegument protein UL36; Provisional
    PRK10263
    Location:171 → 360
    PRK10263; DNA translocase FtsK; Provisional
    sd00020
    Location:499 → 519
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12171
    Location:529 → 553
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
    cl15257
    Location:498 → 565
    GIY-YIG_SF; GIY-YIG nuclease domain superfamily

  19. XM_036162523.1 → XP_036018416.1  cip1-interacting zinc finger protein isoform X19

    UniProtKB/TrEMBL
    Q70KX6
    Conserved Domains (5) summary
    smart00451
    Location:596 → 629
    ZnF_U1; U1-like zinc finger
    PHA03247
    Location:16 → 317
    PHA03247; large tegument protein UL36; Provisional
    sd00020
    Location:450 → 470
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12171
    Location:480 → 504
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
    cl15257
    Location:449 → 516
    GIY-YIG_SF; GIY-YIG nuclease domain superfamily

  20. XM_030252027.2 → XP_030107887.1  cip1-interacting zinc finger protein isoform X20

    UniProtKB/TrEMBL
    Q70KX6
    Conserved Domains (5) summary
    smart00451
    Location:591 → 624
    ZnF_U1; U1-like zinc finger
    PHA03247
    Location:16 → 312
    PHA03247; large tegument protein UL36; Provisional
    sd00020
    Location:445 → 465
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12171
    Location:475 → 499
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
    cl15257
    Location:444 → 511
    GIY-YIG_SF; GIY-YIG nuclease domain superfamily

  21. XM_030252019.2 → XP_030107879.1  cip1-interacting zinc finger protein isoform X11

    UniProtKB/TrEMBL
    Q3TMV1
    Conserved Domains (5) summary
    smart00451
    Location:697 → 730
    ZnF_U1; U1-like zinc finger
    PHA03247
    Location:46 → 418
    PHA03247; large tegument protein UL36; Provisional
    sd00020
    Location:551 → 571
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12171
    Location:581 → 605
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
    cl15257
    Location:550 → 617
    GIY-YIG_SF; GIY-YIG nuclease domain superfamily

  22. XM_030252021.2 → XP_030107881.1  cip1-interacting zinc finger protein isoform X13

    UniProtKB/TrEMBL
    Q3TMV1, Q3UUV0
    Conserved Domains (5) summary
    smart00451
    Location:692 → 725
    ZnF_U1; U1-like zinc finger
    PHA03247
    Location:46 → 413
    PHA03247; large tegument protein UL36; Provisional
    sd00020
    Location:546 → 566
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12171
    Location:576 → 600
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
    cl15257
    Location:545 → 612
    GIY-YIG_SF; GIY-YIG nuclease domain superfamily

  23. XM_030252018.2 → XP_030107878.1  cip1-interacting zinc finger protein isoform X10

    UniProtKB/TrEMBL
    Q3TMV1, Q3TXU6
    Conserved Domains (5) summary
    smart00451
    Location:701 → 734
    ZnF_U1; U1-like zinc finger
    PHA03247
    Location:103 → 375
    PHA03247; large tegument protein UL36; Provisional
    sd00020
    Location:555 → 575
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12171
    Location:585 → 609
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
    cl15257
    Location:554 → 621
    GIY-YIG_SF; GIY-YIG nuclease domain superfamily

  24. XM_036162517.1 → XP_036018410.1  cip1-interacting zinc finger protein isoform X5

    UniProtKB/TrEMBL
    Q3TMV1
    Conserved Domains (5) summary
    smart00451
    Location:741 → 774
    ZnF_U1; U1-like zinc finger
    PHA03247
    Location:46 → 462
    PHA03247; large tegument protein UL36; Provisional
    sd00020
    Location:595 → 615
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12171
    Location:625 → 649
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
    cl15257
    Location:594 → 661
    GIY-YIG_SF; GIY-YIG nuclease domain superfamily

  25. XM_011239169.4 → XP_011237471.1  cip1-interacting zinc finger protein isoform X3

    See identical proteins and their annotated locations for XP_011237471.1

    UniProtKB/TrEMBL
    Q3TMV1, Q8VEH2
    Conserved Domains (6) summary
    smart00451
    Location:746 → 779
    ZnF_U1; U1-like zinc finger
    PHA03247
    Location:46 → 467
    PHA03247; large tegument protein UL36; Provisional
    PRK10263
    Location:272 → 461
    PRK10263; DNA translocase FtsK; Provisional
    sd00020
    Location:600 → 620
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12171
    Location:630 → 654
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
    cl15257
    Location:599 → 666
    GIY-YIG_SF; GIY-YIG nuclease domain superfamily

  26. XM_036162519.1 → XP_036018412.1  cip1-interacting zinc finger protein isoform X14

    UniProtKB/TrEMBL
    Q70KX6
    Conserved Domains (6) summary
    smart00451
    Location:666 → 699
    ZnF_U1; U1-like zinc finger
    PHA03247
    Location:16 → 340
    PHA03247; large tegument protein UL36; Provisional
    PRK10263
    Location:192 → 381
    PRK10263; DNA translocase FtsK; Provisional
    sd00020
    Location:520 → 540
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12171
    Location:550 → 574
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
    cl15257
    Location:519 → 586
    GIY-YIG_SF; GIY-YIG nuclease domain superfamily

  27. XM_036162522.1 → XP_036018415.1  cip1-interacting zinc finger protein isoform X18

    UniProtKB/TrEMBL
    Q70KX6
    Conserved Domains (5) summary
    smart00451
    Location:600 → 633
    ZnF_U1; U1-like zinc finger
    PHA03247
    Location:2 → 274
    PHA03247; large tegument protein UL36; Provisional
    sd00020
    Location:454 → 474
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12171
    Location:484 → 508
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
    cl15257
    Location:453 → 520
    GIY-YIG_SF; GIY-YIG nuclease domain superfamily

  28. XM_030252026.2 → XP_030107886.1  cip1-interacting zinc finger protein isoform X19

    UniProtKB/TrEMBL
    Q70KX6
    Conserved Domains (5) summary
    smart00451
    Location:596 → 629
    ZnF_U1; U1-like zinc finger
    PHA03247
    Location:16 → 317
    PHA03247; large tegument protein UL36; Provisional
    sd00020
    Location:450 → 470
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12171
    Location:480 → 504
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
    cl15257
    Location:449 → 516
    GIY-YIG_SF; GIY-YIG nuclease domain superfamily

  29. XM_030252024.1 → XP_030107884.1  cip1-interacting zinc finger protein isoform X15

    UniProtKB/TrEMBL
    Q70KX6
    Conserved Domains (6) summary
    smart00451
    Location:645 → 678
    ZnF_U1; U1-like zinc finger
    PHA03247
    Location:16 → 319
    PHA03247; large tegument protein UL36; Provisional
    PRK10263
    Location:171 → 360
    PRK10263; DNA translocase FtsK; Provisional
    sd00020
    Location:499 → 519
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12171
    Location:529 → 553
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
    cl15257
    Location:498 → 565
    GIY-YIG_SF; GIY-YIG nuclease domain superfamily

  30. XM_036162521.1 → XP_036018414.1  cip1-interacting zinc finger protein isoform X16

    UniProtKB/TrEMBL
    Q70KX6
    Conserved Domains (5) summary
    smart00451
    Location:640 → 673
    ZnF_U1; U1-like zinc finger
    PHA03247
    Location:16 → 361
    PHA03247; large tegument protein UL36; Provisional
    sd00020
    Location:494 → 514
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12171
    Location:524 → 548
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
    cl15257
    Location:493 → 560
    GIY-YIG_SF; GIY-YIG nuclease domain superfamily

  31. XM_036162518.1 → XP_036018411.1  cip1-interacting zinc finger protein isoform X5

    UniProtKB/TrEMBL
    Q3TMV1
    Conserved Domains (5) summary
    smart00451
    Location:741 → 774
    ZnF_U1; U1-like zinc finger
    PHA03247
    Location:46 → 462
    PHA03247; large tegument protein UL36; Provisional
    sd00020
    Location:595 → 615
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12171
    Location:625 → 649
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
    cl15257
    Location:594 → 661
    GIY-YIG_SF; GIY-YIG nuclease domain superfamily

  32. XM_006498285.4 → XP_006498348.1  cip1-interacting zinc finger protein isoform X17

    See identical proteins and their annotated locations for XP_006498348.1

    UniProtKB/TrEMBL
    Q70KX6
    Conserved Domains (6) summary
    smart00451
    Location:626 → 659
    ZnF_U1; U1-like zinc finger
    PRK10263
    Location:152 → 341
    PRK10263; DNA translocase FtsK; Provisional
    sd00020
    Location:480 → 500
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam03154
    Location:13 → 418
    Atrophin-1; Atrophin-1 family
    pfam12171
    Location:510 → 534
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
    cl15257
    Location:479 → 546
    GIY-YIG_SF; GIY-YIG nuclease domain superfamily
Nucleotide Protein Strain
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